-
1
-
-
0001908456
-
Metabolism and pharmacokinetics of cyclophosphamide and related oxazaphosphorines
-
Powis G, editor. New York: Pergamon Press
-
Sladek NE. Metabolism and pharmacokinetics of cyclophosphamide and related oxazaphosphorines. In: Powis G, editor. Anticancer drugs: reactive metabolism and drug interactions. New York: Pergamon Press; 1994. p. 79-156.
-
(1994)
Anticancer Drugs: Reactive Metabolism and Drug Interactions
, pp. 79-156
-
-
Sladek, N.E.1
-
2
-
-
0027369366
-
Differential activation of cyclophosphamide and ifosphamide by cytochrome P450 2B and 3A in human liver microsomes
-
Chang TKH, Weber GF, Crespi CL, Waxman DJ. Differential activation of cyclophosphamide and ifosphamide by cytochrome P450 2B and 3A in human liver microsomes. Cancer Res 1993;53:5629-37.
-
(1993)
Cancer Res
, vol.53
, pp. 5629-5637
-
-
Chang, T.K.H.1
Weber, G.F.2
Crespi, C.L.3
Waxman, D.J.4
-
3
-
-
0030444353
-
Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans
-
Bohnenstengel F, Hofman U, Eichelbaum M, Kroener HK. Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans. Eur J Clin Pharmacol 1996;51:279-301.
-
(1996)
Eur J Clin Pharmacol
, vol.51
, pp. 279-301
-
-
Bohnenstengel, F.1
Hofman, U.2
Eichelbaum, M.3
Kroener, H.K.4
-
4
-
-
0030799414
-
Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes
-
Ren S, Yang JS, Kalhorn TF, Slattery JT. Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes. Cancer Res 1997;57:4229-35.
-
(1997)
Cancer Res
, vol.57
, pp. 4229-4235
-
-
Ren, S.1
Yang, J.S.2
Kalhorn, T.F.3
Slattery, J.T.4
-
5
-
-
0015610994
-
Biologically active metabolites of cyclophosphamide
-
Colvin M, Padgett CA, Fenselau CA. Biologically active metabolites of cyclophosphamide. Cancer Res 1973;33:915-8.
-
(1973)
Cancer Res
, vol.33
, pp. 915-918
-
-
Colvin, M.1
Padgett, C.A.2
Fenselau, C.A.3
-
6
-
-
0015968586
-
Some studies of the active intermediates formed in the microsomal metabolisms of cyclophosphamide and ifosphamide
-
Connors TA, Cox PJ, Farmer PB, Foster AB, Jarman M. Some studies of the active intermediates formed in the microsomal metabolisms of cyclophosphamide and ifosphamide. Biochem Pharmacol 1974;23:115-29.
-
(1974)
Biochem Pharmacol
, vol.23
, pp. 115-129
-
-
Connors, T.A.1
Cox, P.J.2
Farmer, P.B.3
Foster, A.B.4
Jarman, M.5
-
7
-
-
0016466370
-
Isolation and mass spectral identification of blood metabolites of cyclophosphamide: Evidence for phosphoramide mustard as the biologically active metabolite
-
Struck RF, Kirk MC, Witt MH, Laster WR Jr. Isolation and mass spectral identification of blood metabolites of cyclophosphamide: evidence for phosphoramide mustard as the biologically active metabolite. Biomed Mass Spectrom 1975;2:46-52.
-
(1975)
Biomed Mass Spectrom
, vol.2
, pp. 46-52
-
-
Struck, R.F.1
Kirk, M.C.2
Witt, M.H.3
Laster Jr., W.R.4
-
9
-
-
0018772548
-
Decreased half life of cyclophosphamide in patients under continual treatment
-
D'Incalci M, Bolis G, Facchinetti T, Mangioni C, Morasca L, Morazzoni P, et al. Decreased half life of cyclophosphamide in patients under continual treatment. Eur J Cancer 1979;15:7-10.
-
(1979)
Eur J Cancer
, vol.15
, pp. 7-10
-
-
D'Incalci, M.1
Bolis, G.2
Facchinetti, T.3
Mangioni, C.4
Morasca, L.5
Morazzoni, P.6
-
10
-
-
0020516135
-
Decreased plasma half-life of cyclophosphamide during repeated high-dose administration
-
Graham MI, Shaw IC, Souhami RL, Sidau B, Harper PG, McLean AE. Decreased plasma half-life of cyclophosphamide during repeated high-dose administration. Cancer Chemother Pharmacol 1983;10:192-3.
-
(1983)
Cancer Chemother Pharmacol
, vol.10
, pp. 192-193
-
-
Graham, M.I.1
Shaw, I.C.2
Souhami, R.L.3
Sidau, B.4
Harper, P.G.5
McLean, A.E.6
-
11
-
-
0019301122
-
Plasma half-life and urinary excretion of cyclophosphamide in children
-
Sladek NE, Priest J, Doeden D, Mirocha CJ, Pathre S, Krivit W. Plasma half-life and urinary excretion of cyclophosphamide in children. Cancer Treat Rep 1980;64:1061-6.
-
(1980)
Cancer Treat Rep
, vol.64
, pp. 1061-1066
-
-
Sladek, N.E.1
Priest, J.2
Doeden, D.3
Mirocha, C.J.4
Pathre, S.5
Krivit, W.6
-
12
-
-
0023638209
-
Repeated high-dose cyclophosphamide administration in bone marrow transplantation: Exposure to activated metabolites
-
Schuler U, Ehninger G, Wagner T. Repeated high-dose cyclophosphamide administration in bone marrow transplantation: exposure to activated metabolites. Cancer Chemother Pharmacol 1987;20:248-52.
-
(1987)
Cancer Chemother Pharmacol
, vol.20
, pp. 248-252
-
-
Schuler, U.1
Ehninger, G.2
Wagner, T.3
-
13
-
-
0029863162
-
Conditioning regimen-dependent disposition of cyclophosphamide and hydroxycyclophosphamide in human marrow transplantation patients
-
Slattery JT, Kalhorn TF, McDonald GB, Lambert K, Bucker CD, Bensinger WI, et al. Conditioning regimen-dependent disposition of cyclophosphamide and hydroxycyclophosphamide in human marrow transplantation patients. J Clin Oncol 1996;14:1484-94.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1484-1494
-
-
Slattery, J.T.1
Kalhorn, T.F.2
McDonald, G.B.3
Lambert, K.4
Bucker, C.D.5
Bensinger, W.I.6
-
14
-
-
0016667189
-
Studies on cyclophosphamide metabolites and their related compounds; II: Preparation of an active species of cyclophosphamide and related compounds
-
Takamizawa A, Matsumoto S, Iwata T, Tochino Y, Katagiri K, Yamaguchi K, et al. Studies on cyclophosphamide metabolites and their related compounds; II: preparation of an active species of cyclophosphamide and related compounds. J Med Chem 1975;18:376-83.
-
(1975)
J Med Chem
, vol.18
, pp. 376-383
-
-
Takamizawa, A.1
Matsumoto, S.2
Iwata, T.3
Tochino, Y.4
Katagiri, K.5
Yamaguchi, K.6
-
15
-
-
0001923924
-
Synthesis of N-phosphorylated derivatives of nitrogen mustards with latent cytotoxicity
-
Friedman OM, Boger E, Grubliauskas V, Sommer H. Synthesis of N-phosphorylated derivatives of nitrogen mustards with latent cytotoxicity. J Med Chem 1963;6:50-8.
-
(1963)
J Med Chem
, vol.6
, pp. 50-58
-
-
Friedman, O.M.1
Boger, E.2
Grubliauskas, V.3
Sommer, H.4
-
16
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MA. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.A.1
-
17
-
-
0022597663
-
Erythrocyte aldehyde dehydrogenase activity in alcoholic subjects and its value as a marker for hepatic aldehyde dehydrogenase in subjects with and without liver disease
-
Mathewson K, Record CO. Erythrocyte aldehyde dehydrogenase activity in alcoholic subjects and its value as a marker for hepatic aldehyde dehydrogenase in subjects with and without liver disease. Clin Sci 1986;70:295-9.
-
(1986)
Clin Sci
, vol.70
, pp. 295-299
-
-
Mathewson, K.1
Record, C.O.2
-
19
-
-
0030916085
-
Nonlinear pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide/ aldophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation
-
Chen TL, Kennedy MJ, Anderson LW, Kiraly SB, Black KC, Colvin OM, et al. Nonlinear pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide/ aldophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation. Drug Metab Dispos 1997;25:544-51.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 544-551
-
-
Chen, T.L.1
Kennedy, M.J.2
Anderson, L.W.3
Kiraly, S.B.4
Black, K.C.5
Colvin, O.M.6
-
20
-
-
0030994518
-
Dose escalation of cyclophosphamide in patients with breast cancer: Consequences for pharmacokinetics and metabolism
-
Busse D, Busch FW, Bohnenstengel F, Eichelbaum M, Fischer P, Opalinska J, et al. Dose escalation of cyclophosphamide in patients with breast cancer: consequences for pharmacokinetics and metabolism. J Clin Oncol 1997;15:1885-96.
-
(1997)
J Clin Oncol
, vol.15
, pp. 1885-1896
-
-
Busse, D.1
Busch, F.W.2
Bohnenstengel, F.3
Eichelbaum, M.4
Fischer, P.5
Opalinska, J.6
-
21
-
-
0026748897
-
Cyclophosphamide pharmacokinetics: Correlation with cardiac toxicity and tumor response
-
Ayash LJ, Wright JE, Tretyakov O, Gonin R, Elias A, Wheeler C, et al. Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response. J Clin Oncol 1992;10:995-1000.
-
(1992)
J Clin Oncol
, vol.10
, pp. 995-1000
-
-
Ayash, L.J.1
Wright, J.E.2
Tretyakov, O.3
Gonin, R.4
Elias, A.5
Wheeler, C.6
-
22
-
-
0030951908
-
Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: Response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines
-
Chang TKH, Yu L, Maurel P, Waxman D J. Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res 1997;57:1946-54.
-
(1997)
Cancer Res
, vol.57
, pp. 1946-1954
-
-
Chang, T.K.H.1
Yu, L.2
Maurel, P.3
Waxman, D.J.4
-
23
-
-
0026667068
-
Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde
-
Dockham PA, Lee MO, Sladek NE. Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde. Biochem Pharmacol 1992;43:2453-69.
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 2453-2469
-
-
Dockham, P.A.1
Lee, M.O.2
Sladek, N.E.3
-
24
-
-
0024312693
-
Aldehyde dehydrogenase from human erythrocytes: Structural relationship to the liver cytosolic isozyme
-
Agarwal DP, Cohn P, Goedde HW, Hempel J. Aldehyde dehydrogenase from human erythrocytes: structural relationship to the liver cytosolic isozyme. Enzyme 1989; 42:47-52.
-
(1989)
Enzyme
, vol.42
, pp. 47-52
-
-
Agarwal, D.P.1
Cohn, P.2
Goedde, H.W.3
Hempel, J.4
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