A new global test for the evaluation of the protein C-protein S system

Blood Coagulation and Fibrinolysis

Volumn 7, Issue 4, 1996, Pages 465-469

  Preda, L ^a   Simioni, P ^b,d   Legnani, C ^c   Palareti, G ^c   Poggio, M ^a   Rossi, E ^a   Girolami, A ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d Institute of Medical Semeiotics   (Italy)

Author keywords

APC resistance; functional assay; Inherited thrombophilia; protein C; protein S

Indexed keywords

PROTEIN C; PROTEIN S;

ARTICLE; CONTROLLED STUDY; GENETIC DISORDER; GENETIC PREDISPOSITION; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN DETERMINATION; PROTEIN S DEFICIENCY; PROTHROMBIN TIME; THROMBOSIS;

EID: 0029785068     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-199606000-00006     Document Type: Article

References (21)

1. Allaart CF, Briet E. Familial venous thrombophilia. In: Bloom AL, Forbes CD, Thomas DP, Tuddenham EGD, eds. Haemostasis and Thrombosis, Third Edition. Churchill Livingstone, 1994; 1349-1360.
2. Heijboer H, Brandjes D, Buller HR, Sturk A, ten Cate JW. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis. N Engl J Med 1990; 323: 1512-1516.
3. Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-1008.
4. Bertina RM, Koeleman BPC, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67.
5. Svensson PJ, Dahlback B. Resistance to activated protein C as a basis for a venous thrombosis. N Engl J Med 1994; 330; 517-521.
6. Malia RG, Kitchen S, Greaves M, Preston FE. Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies. Br J Haematol 1990; 76: 101-107.
7. Amer L, Kisiel W, Searles RP, Williams RC Jr. Impairment of the protein C anticoagulant pathway in a patient with systemic lupus erythematosus, anticardiolipin antibodies and thrombosis. Thromb Res 1990; 57: 247-258.
8. Vandenbroucke JP, Koster T, Briet E, et al. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet 1994; 344: 1453-1457.
9. Girolami A, Simioni P, Sartori MT, Zanardi S. Oral contraceptives caused thrombosis in a monoovular twin with protein C deficiency, while the other, without medication, remained asymptomatic. Blood Coag Fibrinol 1992; 3: 119-120.
10. Girolami A, Simioni P, Zanardi S, Scarano L, Girolami B. Patients with APC resistance compared with those with other clotting inhibitor deficiencies show later onset of venous thrombosis during oral contraception. Clin Appl Thromb Hemost 1995; 1: 274-276.
11. Kraus M, Noah M, Fickensher K. The PCAT-A simple screening assay for assessing the functionality of the protein C anticoagulant pathway. Thromb Res 1995; 79: 217-222.
12. ++. Br J Haematol 1993; 85: 521-526.
13. Girolami A, Simioni P, Lazzaro AR, Cordiano I. Severe arterial cerebral thrombosis in a patient with protein S deficiency (moderately reduced total and markedly reduced free protein S): a family study. Thromb Haemost 1989; 61: 144-147.
14. Preda L, Tripodi A, Valsecchi C, et al. A prothrombin time based functional assay of protein S. Thromb Res 1990; 60: 19-32.
15. Dählback B. New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg 506 to Gln mutation in factor V as a pathogenetic risk factor for venous thrombosis. Thromb Haemost 1995; 74: 139-148.
16. Aiach M, Gandrille S, Emmerich J. A review of mutations causing deficiencies of antithrombin, protein C and protein S. Thromb Haemost 1995; 74: 81-89.
17. de Ronde H, Bertina RM. Laboratory diagnosis of APC-resistance: a critical evaluation of the test and the development of diagnostic criteria. Thromb Haemost 1994; 72: 880-886.
18. Simioni P, de Ronde H, Prandoni P, et al. Ischemic stroke in young patients with activated protein C resistance: a report of three cases belonging to three different kindreds. Stroke 1995; 26: 885-890.
19. Koster T, Rosendaal FR, de Ronde H, et al. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden thrombophilia study. Lancet 1993; 342: 1503-1506.
20. Rodgers GM, Kane WH, Pitas RE. Formation of factor Va by atherosclerotic rabbit aorta mediates factor Xa-catalyzed prothrombin activation. J Clin Invest 1988; 81: 1911-1919.
21. Rodgers GM, Conn MT. Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood 1990; 75: 895-901.