Repair of clustered DNA damage caused by high LET radiation in human fibroblasts

Physica Medica

Volumn 14, Issue SUPPL. 1, 1998, Pages 24-28

  Rydberg, B ^a   Loblich M ^a   Cooper, P K ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

DNA damage; DNA double strand breaks; DNA repair; Ionizing radiation

Indexed keywords

CELL DNA;

CONFERENCE PAPER; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; IONIZING RADIATION; LINEAR ENERGY TRANSFER; NORMAL HUMAN; RADIOBIOLOGY; SKIN FIBROBLAST;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

CELLS, CULTURED; DNA; DNA DAMAGE; DNA FRAGMENTATION; DNA REPAIR; DNA, SINGLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; HEAVY IONS; HUMANS; LINEAR ENERGY TRANSFER; NUCLEIC ACID HYBRIDIZATION; PARTICLE ACCELERATORS; RADIOBIOLOGY; SKIN; THYMINE; X-RAYS;

EID: 0031652738     PISSN: 11201797     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (18)

1. Ward JF. Biochemistry of DNA lesions. Radiat Res 1985: 104; S103-S111.
2. Chatterjee A, Holley WR. Energy deposition mechanisms and biochemical aspects of DNA strand breaks by ionizing radiation. Int J Quant Chem 1991: 39; 709-727.
3. Rydberg B. Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. II. Experimental detection. Radiat Res 1996: 145; 200-9.
4. Löbrich M, Cooper PK, Rydberg B. Non-random distribution of DNA double-strand breaks induced by particle irradiation. Int J Radiat Biol 1996: 70; 493-503.
5. Rydberg B. Measurements of chromatin conformation in living cells: Experimental support for a Zig-Zag model of the 30 nm chromatin fiber. J Mol Biol 1997.
6. Kellerer AM, Rossi HH. The Theory of Dual Radiation Action. Current Topics in Radiation Research Quarterly 1972: 8; 85-158.
7. Goodhead DT, Thacker J, Cox R. Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. Int J Radiat Biol 1993: 63; 543-556.
8. Leadon SA, Hanawalt PC. Monoclonal Antibody to DNA Containing Thymine Glycol. Mutat Res 1983: 112; 191-200.
9. Leadon SA. Immunological Probes for Lesions and Repair Patches in DNA. In: DNA Repair, A Laboratory Manual of Research Procedures. Friedberg EC and Hanawalt PC. Eds. Marcel Dekker. New York 1988; 311-326.
10. Rydberg B, Lobrich M, Cooper PK. DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method. Radiat Res 1994: 139; 133-41.
11. Löbrich M, Rydberg B, Cooper PK. DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. II. Probing individual notI fragments by hybridization. Radiat Res 1994: 139; 142-51.
12. Ichikawa H, et al. Long-distance restriction mapping of the proximal long arm of human chromosome 21 with NotI linking clones. Proc Natl Acad Sci U S A 1992: 89; 23-27.
13. Chaudhry MA, Weinfeld M. The action of Escherichia coli endonuclease III on multiply damaged sites in DNA. J Mol Biol 1995: 249; 914-922.
14. Rydberg B. DNA strand breaks induced by low-energy heavy ions. Int J Radiat Biol 1985: 47; 57-61.
15. Ritter MA, Cleaver JE, Tobias CA. High-LET radiations induce a large proportion of non-rejoining DNA breaks. Nature 1977: 266; 653-655.
16. 241Am α-particles orbleomycin. Int J Radiat Biol 1987: 51; 209-217.
17. Löbrich M, Ikpeme S, Kiefer J. DNA double-strand break measurement in mammalian cells: An approach using rarely-cutting restriction enzymes and gene probing. Int J Radiat Biol 1994: 65; 623-630.
18. Löbrich M, Rydberg B, Cooper PK. Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends. Proc Natl Acad Sci U S A 1995: 92; 12050-4.