Human endothelin-converting enzyme-1β mRNA expression is regulated by an alternative promoter

Journal of Cardiovascular Pharmacology

Volumn 31, Issue SUPPL. 1, 1998, Pages

  Funke Kaiser, H ^a   Orzechowski, H D ^a   Richter, M ^a   Paul, M ^a,b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Big endothelins; ECE 1 isoforms; Endothelin converting enzymes; Luciferase reporter vector

Indexed keywords

ASPARTIC PROTEINASE; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN-CONVERTING ENZYME 1; MESSENGER RNA; METALLOPROTEINASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL LINE; CHO CELL; CYTOLOGY; GENE DELETION; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETICS; HAMSTER; HUMAN; METABOLISM; PHYSIOLOGY; PLASMID; POLYMERASE CHAIN REACTION; PROMOTER REGION; VASCULAR ENDOTHELIUM;

ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CHO CELLS; CRICETINAE; ENDOTHELIUM, VASCULAR; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE LIBRARY; HUMANS; METALLOENDOPEPTIDASES; PLASMIDS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RNA, MESSENGER;

EID: 0031627513     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199800001-00004     Document Type: Article

References (12)

1. Shimada K, Takahashi M, et al. Identification and characterization of two isoforms of ECE-1. FEBS Lett 1995;371:140-4.
2. Valdenaire O, Rohrbacher E, Mattei MG, et al. Organization of the gene encoding the human endothelin-converting enzyme (ECE-1). J Biol Chem 1995;270:29794-8.
3. Schmidt M, Kroger B, et al. Molecular characterization of human and bovine ECE-1. FEBS Lett 1994;356:238-43.
4. Shimada K, Matsushita Y, et al. Cloning and functional expression of human endothelin-converting enzyme cDNA. Biochem Biophys Res Commun 1995;207:807-12.
5. Hubert C, Houot AM, Corvol P, Soubrier F. Structure of the angiotensin I-converting enzyme gene. J Biol Chem 1991;266:15377.
6. Ishimaru F, Shipp MA. Analysis of the human CD10/neutral endopeptidase 24.11 promoter region. Blood 1995;85:3199-207.
7. Breitbart RE, Andreadis A, et al. Alternative splicing. Annu Rev Biochem 1987;56:467-95.
8. Shiraki T, Sawamura T, Ikura T, et al. Genetic transfer of ECE activity to CHO-K1 cells. FEBS Lett 1994;351:197-200.
9. Orzechowski HD, Richter CM, Funke-Kaiser H, et al. Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells. J Mol Med 1997;75:512-21.
10. Iwasaka C, Katsuhiro T, Mayumi A, Sato Y. Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells. J Cell Physiol 1996;169:522-31.
11. Wernert N, Raes MB, Lassalle P, et al. c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans. Am J Pathol 1992;140:119.
12. Minammino T, Kurihara HK, Takahashi M, et al. Endothelin-converting enzyme expression in the rat vascular injury model and human atherosclerosis. Circulation 1997;95:221-30.