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1
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0029959459
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In the absence of endogenous IL-10 mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α
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Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T. Cheever A. Kuhn R, Muller W, Trinchieri G & Sher A (1996). In the absence of endogenous IL-10 mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α. Journal of Immunology. 157: 798-805.
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Defects in cell-mediated immunity affect chronic, but not innate resistance of mice to Mycobacterium avium infection
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Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection
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Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity
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King CL, Medhat A, Malhotra I, Nafeh M, Helmy A, Khaudary J, Ibrahim S, El-Sherbiny M, Zaky S, Stupi RJ, Brustoski K, Shehata M & Shata MT (1996). Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. Journal of Immunology, 156: 4715-4721.
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Analysis of granuloma formation in double cytokine deficient mice reveals a central role for IL-10 in polarizing both Th1 and Th2-type cytokine responses in vivo
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in press
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Wynn TA, Morawetz R. Scharton-Kersten T, Hieny S, Morse III HC, Kuhn R & Muller W (1998). Analysis of granuloma formation in double cytokine deficient mice reveals a central role for IL-10 in polarizing both Th1 and Th2-type cytokine responses in vivo. Journal of Immunology (in press).
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B cell-deficient mice exposed to Schistosoma mansonidevelop exacerbated egg pathology which fails to down-modulate during chronic infection
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0027388944
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Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance
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Actor JK, Shirai M, Kullberg MC, Buller RM, Sher A & Berzofsky JA (1993). Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. Proceedings of the National Academy of Sciences, USA, 90: 948-952.
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Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris
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Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni
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Infection of human immunodeficiency virus 1 transgenic mice with Toxoplasma gondii stimulates proviral transcription in macrophages in vivo
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Cellular immunity and a type 1 cytokine profile in protection against HIV infection and progression to AIDS
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