Effect of FTY720 on immunoregulation in concordant xenotransplantation

Transplant International

Volumn 11, Issue SUPPL. 1, 1998, Pages

  Fukuda, Y ^a,b   Ohdan, H ^a   Miyata, Y ^a   Shintaku, S ^a   Dohi, K ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b National Hiroshima Hospital   (Japan)

Author keywords

Apoptosis; FK506; FTY720; Hamster to rat; Xenotransplantation

Indexed keywords

DRUG DERIVATIVE; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; PROPANEDIOL DERIVATIVE; SPHINGOSINE;

ANIMAL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; DRUG EFFECT; GRAFT SURVIVAL; HAMSTER; HISTOCOMPATIBILITY; HUMAN; IMMUNOLOGY; LEWIS RAT; RAT; SKIN TRANSPLANTATION; T LYMPHOCYTE; XENOGRAFT;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CRICETINAE; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; PROPYLENE GLYCOLS; RATS; RATS, INBRED LEW; SKIN TRANSPLANTATION; SPHINGOSINE; T-LYMPHOCYTES; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HETEROLOGOUS;

EID: 0031609665     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-2277.1998.tb01182.x     Document Type: Article

References (9)

1. Alexander JW, Masroor S, Levy A, Galla K (1994) A new strategy for prolonging xenograft survival. Transplantation 58: 14-17
2. Blin N, Stafford DM (1976) A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res 3: 2303
3. Chiba K, Hoshino Y, Suzuki C, et al (1996) FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats. Transplant Proc 28: 1058-1059
4. Hoshino Y, Suzuki C, Ohtsuki M, et al (1996) FTY720, a novel immunosuppressant possessing unique mechanisms. IL Long-term graft survival induction in rat heterotopic cardiac allografts and synergistic effect in combination with cyclosporine A. Transplant Proc 28: 1060-1061
5. Miyazawa H, Murase N, Demetris AJ, et al (1995) Hamster-to-rat kidney xenotransplantation. Transplantation 59: 1183-1188
6. Murase N, Starzl TE, Demetris AJ, et al (1993) Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs. Transplantation 55: 701-708
7. Nishitani S, Tsubata T, Murakami M, Okamoto M, Honjo T (1993) The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. J Exp Med 178: 1247-1254
8. Suzuki S, Enosawa S, Kakefuda T, et al (1996) A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. Transplantation 61: 200-205
9. Suzuki S, Li XK, Enosawa S, et al (1996) A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocyte. Immunology 89: 518-523