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Volumn 10, Issue 2, 1998, Pages 99-109

Clinical significance of the increased Multidrug Resistance-associated Protein (MRP) gene expression in patients with primary breast cancer

Author keywords

Multidrug resistance (MDR); Multidrug resistance associated protein (MRP); Polymerase chain reaction (PCR); Topoisomerase

Indexed keywords

ABC TRANSPORTER; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; TUMOR PROTEIN;

EID: 0031603871     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (33)

References (53)
  • 1
    • 0022444431 scopus 로고
    • Amplification and expression of genes associated with multidrug resistance in mammalian cells
    • Scotto, K. W.; Biedler, J. L.; Melera, P. W. Amplification and expression of genes associated with multidrug resistance in mammalian cells. Science 232:751-755; 1986.
    • (1986) Science , vol.232 , pp. 751-755
    • Scotto, K.W.1    Biedler, J.L.2    Melera, P.W.3
  • 2
    • 0024329881 scopus 로고
    • The biochemistry of P-glycoprotein-mediated multidrug resistance
    • Endicott, J.; Ling, V. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58:137-171; 1989.
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 137-171
    • Endicott, J.1    Ling, V.2
  • 3
    • 0024279163 scopus 로고
    • The multidrug transporter, a double-edged sword
    • Gottesman, M. M.; Pastan, I. The multidrug transporter, a double-edged sword. J. Biol. Chem. 263:12163-12166; 1988.
    • (1988) J. Biol. Chem. , vol.263 , pp. 12163-12166
    • Gottesman, M.M.1    Pastan, I.2
  • 9
    • 0024409641 scopus 로고
    • Electrophoretic analysis of 248 clinical breast cancer specimens for P-glycoprotein overexpression of gene amplification
    • Merkel, D. E.; Fuqua, S. A. W.; Tandon, A. K.; Hill, S. M.; Buzdar, A. U.; McGuire, W. L. Electrophoretic analysis of 248 clinical breast cancer specimens for P-glycoprotein overexpression of gene amplification. J. Clin. Oncol. 7:1129-1136; 1989.
    • (1989) J. Clin. Oncol. , vol.7 , pp. 1129-1136
    • Merkel, D.E.1    Fuqua, S.A.W.2    Tandon, A.K.3    Hill, S.M.4    Buzdar, A.U.5    McGuire, W.L.6
  • 10
    • 0025105779 scopus 로고
    • Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues
    • van der Valk, P.; van Kalken, C. K.; Ketelaars, H. Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Ann. Oncol. 1:56-64; 1990.
    • (1990) Ann. Oncol. , vol.1 , pp. 56-64
    • Van Der Valk, P.1    Van Kalken, C.K.2    Ketelaars, H.3
  • 12
    • 0025162113 scopus 로고
    • Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line
    • de-Jong, S.; Zijlstra, J. G.; de-Vries, E. G.; Mulder, N. H. Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line. Cancer Res. 50:304-309; 1990.
    • (1990) Cancer Res. , vol.50 , pp. 304-309
    • De-Jong, S.1    Zijlstra, J.G.2    De-Vries, E.G.3    Mulder, N.H.4
  • 13
    • 0026378295 scopus 로고
    • Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells
    • Takano, H.; Kohno, K.; Ono, M.; Uchida, Y.; Kuwano, M. Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells. Cancer Res. 51:3951-3957; 1991.
    • (1991) Cancer Res. , vol.51 , pp. 3951-3957
    • Takano, H.1    Kohno, K.2    Ono, M.3    Uchida, Y.4    Kuwano, M.5
  • 14
    • 0028985716 scopus 로고
    • Topoisomerase IIα and β as therapy targets in breast cancer
    • Isaacs, R. J.; Davies, S. L.; Wells, N. J.; Harris, A. L. Topoisomerase IIα and β as therapy targets in breast cancer. Anticancer Drugs 6:195-211; 1995.
    • (1995) Anticancer Drugs , vol.6 , pp. 195-211
    • Isaacs, R.J.1    Davies, S.L.2    Wells, N.J.3    Harris, A.L.4
  • 16
    • 0028054888 scopus 로고
    • Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs
    • Grant, C. E.; Valdimarsson, G.; Hipfner, D. R.; Almquist, K. C.; Cole, S. P. C.; Deeley, R. G. Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res. 54:357-361; 1994.
    • (1994) Cancer Res. , vol.54 , pp. 357-361
    • Grant, C.E.1    Valdimarsson, G.2    Hipfner, D.R.3    Almquist, K.C.4    Cole, S.P.C.5    Deeley, R.G.6
  • 19
    • 0028043795 scopus 로고
    • Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma
    • Bordow, S. B.; Haber, M.; Madafiglio, J.; Cheung, B.; Marshall, G. M.; Norris, M. D. Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. Cancer Res. 53:5036-5040; 1994.
    • (1994) Cancer Res. , vol.53 , pp. 5036-5040
    • Bordow, S.B.1    Haber, M.2    Madafiglio, J.3    Cheung, B.4    Marshall, G.M.5    Norris, M.D.6
  • 20
    • 0030031845 scopus 로고    scopus 로고
    • Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma
    • Norris, M. D.; Bordow, S. B.; Marshall, G. M.; Haber, P. S.; Cohn, S. L.; Haber, M. Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma. N. Engl. J. Med. 334:231-238; 1996.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 231-238
    • Norris, M.D.1    Bordow, S.B.2    Marshall, G.M.3    Haber, P.S.4    Cohn, S.L.5    Haber, M.6
  • 23
    • 0030029210 scopus 로고    scopus 로고
    • Alterations in expression of the multidrug resistance-associated protein (MRP) gene in high-grade transitional cell carcinoma of the bladder
    • Clifford, S. C.; Neal, D. E.; Lunec, J. Alterations in expression of the multidrug resistance-associated protein (MRP) gene in high-grade transitional cell carcinoma of the bladder. Br. J. Cancer 73: 659-666; 1996.
    • (1996) Br. J. Cancer , vol.73 , pp. 659-666
    • Clifford, S.C.1    Neal, D.E.2    Lunec, J.3
  • 24
    • 70449185514 scopus 로고
    • Histological grading and prognosis in breast cancer
    • Bloom, H. J. G.; Richardson, W. W. Histological grading and prognosis in breast cancer. Br. J. Cancer 11:359-377; 1957.
    • (1957) Br. J. Cancer , vol.11 , pp. 359-377
    • Bloom, H.J.G.1    Richardson, W.W.2
  • 25
    • 0030979119 scopus 로고    scopus 로고
    • Clinical significance of multidrug resistance-associated protein (MRP) and P-glycoprotein in patients with bladder cancer
    • Nakagawa, M.; Emoto, A.; Nasu, N.; Hanada, T.; Kuwano, M.; Cole, S. P. C.; Nomura, Y. Clinical significance of multidrug resistance-associated protein (MRP) and P-glycoprotein in patients with bladder cancer. J. Urol. 157:1260-1264; 1997.
    • (1997) J. Urol. , vol.157 , pp. 1260-1264
    • Nakagawa, M.1    Emoto, A.2    Nasu, N.3    Hanada, T.4    Kuwano, M.5    Cole, S.P.C.6    Nomura, Y.7
  • 26
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P.; Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159; 1987.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 28
    • 0028009810 scopus 로고
    • Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance
    • Schneider, E.; Horton, J. K.; Yang, C.-H.; Nakagawa, M.; Cowan, K. H. Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance. Cancer Res. 54:152-158; 1994.
    • (1994) Cancer Res. , vol.54 , pp. 152-158
    • Schneider, E.1    Horton, J.K.2    Yang, C.-H.3    Nakagawa, M.4    Cowan, K.H.5
  • 30
    • 0028315894 scopus 로고
    • Inducible regulatory elements in the human cyclin D1 promoter
    • Herber, B.; Truss, M.; Beato, M.; Mueller, R. Inducible regulatory elements in the human cyclin D1 promoter. Oncogene 9:1295-1304; 1994.
    • (1994) Oncogene , vol.9 , pp. 1295-1304
    • Herber, B.1    Truss, M.2    Beato, M.3    Mueller, R.4
  • 31
    • 0024973417 scopus 로고
    • Avoiding false positives with PCR
    • Kwok, S.; Higuchi, R. Avoiding false positives with PCR. Nature 339:237-238; 1989.
    • (1989) Nature , vol.339 , pp. 237-238
    • Kwok, S.1    Higuchi, R.2
  • 32
    • 0028268620 scopus 로고
    • Expression complementary DNA library transfer establishes MRP as a mullidrug resistance gene
    • Kruh, G. D.; Chan, A.; Myers, K.; Gaughan, K.; Miki, T.; Aaronson, S. A. Expression complementary DNA library transfer establishes MRP as a mullidrug resistance gene. Cancer Res. 54:1649-1652; 1994.
    • (1994) Cancer Res. , vol.54 , pp. 1649-1652
    • Kruh, G.D.1    Chan, A.2    Myers, K.3    Gaughan, K.4    Miki, T.5    Aaronson, S.A.6
  • 34
    • 0027960078 scopus 로고
    • Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
    • Cole, S. P.; Sparks, K. E.; Fraser, K.; Loe, D. W.; Grant, C. E.; Wilson, G. M.; Deeley, R. G. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res. 54:5902-5910; 1994.
    • (1994) Cancer Res. , vol.54 , pp. 5902-5910
    • Cole, S.P.1    Sparks, K.E.2    Fraser, K.3    Loe, D.W.4    Grant, C.E.5    Wilson, G.M.6    Deeley, R.G.7
  • 35
    • 0028070776 scopus 로고
    • Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells
    • Abe, T.; Hasegawa, S.; Taniguchi, K.; Yokomizo, A.; Kuwano, T.; Ono, M.; Mori, T.; Hori, S.; Kohno, K.; Kuwano, M. Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells. Int. J. Cancer 58: 860-864; 1994.
    • (1994) Int. J. Cancer , vol.58 , pp. 860-864
    • Abe, T.1    Hasegawa, S.2    Taniguchi, K.3    Yokomizo, A.4    Kuwano, T.5    Ono, M.6    Mori, T.7    Hori, S.8    Kohno, K.9    Kuwano, M.10
  • 36
    • 0029018919 scopus 로고
    • Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines
    • Hasegawa, S.; Abe, T.; Naito, S.; Kotoh, S.; Kumazawa, J.; Hipfner, D. R.; Deeley, R. G.; Cole, S. P.; Kuwano, M. Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines. Br. J. Cancer 71:907-913; 1995.
    • (1995) Br. J. Cancer , vol.71 , pp. 907-913
    • Hasegawa, S.1    Abe, T.2    Naito, S.3    Kotoh, S.4    Kumazawa, J.5    Hipfner, D.R.6    Deeley, R.G.7    Cole, S.P.8    Kuwano, M.9
  • 37
    • 0029748607 scopus 로고    scopus 로고
    • Overexpression of multidrug resistance protein gene in human cancer cell lines selecled for drug resistance to epipodophyllotoxins
    • Koike, K.; Abe, T.; Hisano, T.; Kubo, T.; Wada, M.; Kohno, K.; Kuwano, M. Overexpression of multidrug resistance protein gene in human cancer cell lines selecled for drug resistance to epipodophyllotoxins. Jpn. J. Cancer Res. 87:765-772; 1996.
    • (1996) Jpn. J. Cancer Res. , vol.87 , pp. 765-772
    • Koike, K.1    Abe, T.2    Hisano, T.3    Kubo, T.4    Wada, M.5    Kohno, K.6    Kuwano, M.7
  • 38
    • 0028151280 scopus 로고
    • High expression of the multidrug resistance-associated protein (MRP) in chronic and prolymphocytic leukaemia
    • Burger, H.; Nooter, K.; Sonneveld, P.; Van, W. K.; Zaman, G. J.; Stoter, G. High expression of the multidrug resistance-associated protein (MRP) in chronic and prolymphocytic leukaemia. Br. J. Haematol. 88:348-356; 1994.
    • (1994) Br. J. Haematol. , vol.88 , pp. 348-356
    • Burger, H.1    Nooter, K.2    Sonneveld, P.3    Van, W.K.4    Zaman, G.J.5    Stoter, G.6
  • 39
  • 40
    • 0028147453 scopus 로고
    • Mdr1 gene expression in childhood acute lymphoblastic leukemias and lymphomas: A critical evaluation by four techniques
    • Brophy, N. A.; Marie, J. P.; Rojas, V. A.; Warnke, R. A.; McFall, P. J.; Smith, S. D.; Sikic, B. I. Mdr1 gene expression in childhood acute lymphoblastic leukemias and lymphomas: A critical evaluation by four techniques. Leukemia 8:327-335; 1994.
    • (1994) Leukemia , vol.8 , pp. 327-335
    • Brophy, N.A.1    Marie, J.P.2    Rojas, V.A.3    Warnke, R.A.4    McFall, P.J.5    Smith, S.D.6    Sikic, B.I.7
  • 41
    • 0028173370 scopus 로고
    • Quantitative immunocytochemical assays of P-glycoprotein in breast carcinomas: Correlation to messenger RNA expression and to immunohistochemical prognostic indicators
    • Charpin, C.; Vielh, P.; Duffaud, F.; Devictor, B.; Andrac, L.; Lavaut, M. N.; Allasia, C.; Horschowski, N.; Piana, L. Quantitative immunocytochemical assays of P-glycoprotein in breast carcinomas: Correlation to messenger RNA expression and to immunohistochemical prognostic indicators. J. Natl. Cancer Inst. 86:1539-1545; 1994.
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 1539-1545
    • Charpin, C.1    Vielh, P.2    Duffaud, F.3    Devictor, B.4    Andrac, L.5    Lavaut, M.N.6    Allasia, C.7    Horschowski, N.8    Piana, L.9
  • 42
    • 0029954845 scopus 로고    scopus 로고
    • Biology of the multidrug resistance protein, MRP
    • Loe, D. W.; Deeley, R. G.; Cole, S. P. C. Biology of the multidrug resistance protein, MRP. Eur. J. Cancer 32A:945-957; 1996.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 945-957
    • Loe, D.W.1    Deeley, R.G.2    Cole, S.P.C.3
  • 43
    • 0024820183 scopus 로고
    • The direct activation of human multidrug resistance gene (MDR1) by anticancer asents
    • Kohno, K.; Sato, S.; Takano, H.; Matsuo, K.; Kuwano, M. The direct activation of human multidrug resistance gene (MDR1) by anticancer asents. Biochem. Biophys. Res. Commun. 165:1415-1421; 1989.
    • (1989) Biochem. Biophys. Res. Commun. , vol.165 , pp. 1415-1421
    • Kohno, K.1    Sato, S.2    Takano, H.3    Matsuo, K.4    Kuwano, M.5
  • 44
    • 0027564360 scopus 로고
    • Enhanced expression of the human multidrug resistance 1 gene in response to UV light irradiation
    • Uchiumi, T.; Kohno, K.; Tanimura, H.; Matsuo, K.; Sato, S.; Uchida, Y.; Kuwano, M. Enhanced expression of the human multidrug resistance 1 gene in response to UV light irradiation. Cell Growth Differ. 4:147-157; 1993.
    • (1993) Cell Growth Differ. , vol.4 , pp. 147-157
    • Uchiumi, T.1    Kohno, K.2    Tanimura, H.3    Matsuo, K.4    Sato, S.5    Uchida, Y.6    Kuwano, M.7
  • 45
    • 0027406440 scopus 로고
    • Topoisomerase II alpha co-amplification with 3rbB2 in human primary breast cancer and breast cancer cell lines: Relationship to m-AMSA and miloxantrone sensitivity
    • Smith, K.; Houlbrook, S.; Greenall, M.; Carmichael, J.; Harris, A. L. Topoisomerase II alpha co-amplification with 3rbB2 in human primary breast cancer and breast cancer cell lines: Relationship to m-AMSA and miloxantrone sensitivity. Oncogene 8:933-938; 1993.
    • (1993) Oncogene , vol.8 , pp. 933-938
    • Smith, K.1    Houlbrook, S.2    Greenall, M.3    Carmichael, J.4    Harris, A.L.5
  • 46
    • 0027326254 scopus 로고
    • Immunocytochemical detection of DNA topoisomerase type II in primary breast carcinomas: Correlation with clinico-pathological features
    • Tuccari, G.; Rizzo, A.; Giuffré, G.; Barresi, G. Immunocytochemical detection of DNA topoisomerase type II in primary breast carcinomas: Correlation with clinico-pathological features. Virchows Archiv. A Pathol. Anat. 423:51-55; 1993.
    • (1993) Virchows Archiv. A Pathol. Anat. , vol.423 , pp. 51-55
    • Tuccari, G.1    Rizzo, A.2    Giuffré, G.3    Barresi, G.4
  • 47
    • 0025114356 scopus 로고
    • Reduction of drug accumulation and DNA topoisomerase II activity in acquired teniposide-resistant human cancer KB cell lines
    • Matsuo, K.; Kohno, K.; Takano, H.; Sato, S.; Kiue, A.; Kuwano, M. Reduction of drug accumulation and DNA topoisomerase II activity in acquired teniposide-resistant human cancer KB cell lines. Cancer Res. 50:5819-5824; 1990.
    • (1990) Cancer Res. , vol.50 , pp. 5819-5824
    • Matsuo, K.1    Kohno, K.2    Takano, H.3    Sato, S.4    Kiue, A.5    Kuwano, M.6
  • 48
    • 0027479547 scopus 로고
    • Enhanced expression of the DNA topoisomerase II gene in response to heat shock stress in human epidermoid cancer KB cells
    • Matsuo, K.; Kohno, K.; Sato, S.; Uchiumi, T.; Tanimura, H.; Yamada, Y.; Kuwano, M. Enhanced expression of the DNA topoisomerase II gene in response to heat shock stress in human epidermoid cancer KB cells. Cancer Res. 53:1085-1090; 1993.
    • (1993) Cancer Res. , vol.53 , pp. 1085-1090
    • Matsuo, K.1    Kohno, K.2    Sato, S.3    Uchiumi, T.4    Tanimura, H.5    Yamada, Y.6    Kuwano, M.7
  • 49
    • 0028678028 scopus 로고
    • Resistance of mammalian tumor cells to inhibitors of DNA topoisomerase II
    • Liu, L. F., eds. Boston: Academic Press
    • Beck, W. T.; Danks, M. K. Resistance of mammalian tumor cells to inhibitors of DNA topoisomerase II. In: Liu, L. F., eds. DNA topoisomerases; topoisomerase-targeting drugs. Boston: Academic Press; 1994:145-169.
    • (1994) DNA Topoisomerases; Topoisomerase-targeting Drugs , pp. 145-169
    • Beck, W.T.1    Danks, M.K.2
  • 50
    • 0028006314 scopus 로고
    • Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: Demonstration of tumor-type specificity and implications for cancer chemotherapy
    • Husain, I.; Mohler, J. L.; Seigler, H. F.; Besterman, J. M. Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: Demonstration of tumor-type specificity and implications for cancer chemotherapy. Cancer Res. 54:539-546; 1994.
    • (1994) Cancer Res. , vol.54 , pp. 539-546
    • Husain, I.1    Mohler, J.L.2    Seigler, H.F.3    Besterman, J.M.4
  • 52
    • 0025970229 scopus 로고
    • D11S287, a putative oncogene on chromosome IIq13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1
    • Lammie, G. A.; Fantl, V.; Smith, R.; Schuuring, E.; Brookes, S.; Michalides, R.; Dickson, C.; Arnold, A.; Peters, G. D11S287, a putative oncogene on chromosome IIq13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1. Oncogene 6:439-444; 1991.
    • (1991) Oncogene , vol.6 , pp. 439-444
    • Lammie, G.A.1    Fantl, V.2    Smith, R.3    Schuuring, E.4    Brookes, S.5    Michalides, R.6    Dickson, C.7    Arnold, A.8    Peters, G.9


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