Structure-function relationships of mitochondrial monoamine oxidase A and B: Chimaeric enzymes and site-directed mutagenesis studies

Journal of Neural Transmission, Supplement

Volumn , Issue 52, 1998, Pages 189-200

  Cesura, A M ^a   Gottowik, J ^a   Lang, G ^a   Malherbe, P ^a   Da Prada, M ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); LAZABEMIDE; HISTIDINE; HYBRID PROTEIN; ISOENZYME; MONOAMINE OXIDASE INHIBITOR; N (2 AMINOETHYL) 5 (3 FLUOROPHENYL) 4 THIAZOLECARBOXAMIDE; RO 41-1049; THIAZOLE DERIVATIVE; THREONINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHIMERA; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; AMINO ACID SUBSTITUTION; BINDING SITE; CELL LINE; CHEMISTRY; GENETIC TRANSFECTION; KIDNEY; KINETICS; METABOLISM; MOLECULAR CLONING; POLYMERASE CHAIN REACTION;

AMINO ACID SUBSTITUTION; BINDING SITES; CELL LINE; CLONING, MOLECULAR; HISTIDINE; HUMANS; ISOENZYMES; KIDNEY; KINETICS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; MUTAGENESIS, SITE-DIRECTED; POLYMERASE CHAIN REACTION; RECOMBINANT FUSION PROTEINS; THIAZOLES; THREONINE; TRANSFECTION;

EID: 0031596693     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6499-0_18     Document Type: Article

References (28)

1. Bach AJW, Lan NC, Johnson DL, Abell CW, Bembenek ME, Kwan SW, Seeburg P, Shih JC (1988) cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc Natl Acad Sci USA 85: 4934-4938
2. Bertocci B, Miggiano V, Da Prada M, Denbic Z, Lahm H-W, Malherbe P (1991) Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form. Proc Natl Acad Sci USA 88: 1416-1420
3. Cesura AM, Pletscher A (1992) The new generation of monoamine oxidase inhibitors. Prog Drug Res 38: 171-297
4. 3H]Ro 19-6327: a reversible ligand and affinity labelling probe for monoamine oxidase-A. Eur J Pharmacol 162: 457-465
5. 3H]Ro 41-1049 to the active site of human monoamine oxidase-A. Mol Pharmacol 37: 358-366
6. Cesura AM, Gottowik J, Lahm H-W, Lang G, Imhof R, Malherbe P, Röthlisberger U, Da Prada M (1996) Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis. Eur J Biochem 236: 996-1002
7. Da Prada M, Kettler R, Keller HH, Burkard WP, Muggli-Maniglio D, Haefely WE (1989) Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A. J Pharmacol Exp Ther 248: 400-414
8. Da Prada M, Kettler R, Keller HH, Cesura AM, Richards JG, Saura Marti J, Muggli-Maniglio D, Wyss P-C, Kyburz E, Imhof R (1990) From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors. J Neural Transm [Suppl] 29: 279-292
9. Dostert P, Strolin-Benedetti M (1991) Structure-modulated recognition of substrates and inhibitors by monoamine oxidase A and B. Biochem Soc Trans 19: 207-211
10. Efange SMN, Michelson RH, Tan AK, Krueger MJ, Singer TP (1993) Molecular size and flexibility as determinants of selectivity in the oxydation of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs by monoamine oxidase A and B. J Med Chem 36: 1278-1283
11. Gottowik J, Cesura AM, Malherbe P, Lang G, Da Prada M (1993) Characterisation of wild-type and mutant forms of human monoamine oxidase A and B expressed in a mammalian cell line. FEBS Lett 317: 152-156
12. Gottowik J, Malherbe P, Lang G, Da Prada M, Cesura AM (1995) Structure/function relationships of mitochondrial monoamine oxidase A and B chimeric forms. Eur J Biochem 230: 934-942
13. Grimsby J, Chen K, Wang L-J, Lan NC, Shih JC (1991) Human monoamine oxidase A and B genes exhibit identical exon-intron organisation. Proc Natl Acad Sci USA 88: 3637-3641
14. Higuchi R, Krummel B, Saiki RK (1988) A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions. Nucl Acids Res 16: 7351-7367
15. Horton R, Hunt HD, Ho SN, Pullen JK, Pease LR (1989) Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77: 61-68
16. Kearney EB, Salach JI, Walker WH, Seng RL, Kenney W, Zeszotek E, Singer TP (1971) The covalently bound flavin of hepatic monoamine oxidase. 1. Isolation and sequence of a flavin peptide and evidence for binding in the 8α position. Eur J Biochem 24: 321-327
17. Kwan S-K, Lewis DA, Zhou BP, Abell CW (1995) Characterization of a dinucleotide-binding site in monoamine oxidase B by site-directed mutagenesis. Arch Biochem Biophys 316: 385-391
18. Löffler J, Feltz A (1990) Lipoplyamine-mediated transfection allows gene expression studies in primary neuronal cells. J Neurochem 54: 1812-1815
19. Mitoma J, Ito A (1992) Mitochondrial targeting signal of rat liver monoamine oxidase B is located at its carboxy terminus. J Biochem 111: 20-24
20. Sanger F, Coulson A, Barrell B, Smith A, Roe B (1980) Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol 143: 161-178
21. Silverman RB (1991) The use of mechanism-based inactivators to probe the mechanism of monoamine oxidase. Biochem Soc Trans 19: 201-206
22. Weyler W (1994) Functional expression of C-terminally truncated human monoamine oxidase type A in Saccharomyces cerevisiae. J Neural Transm [Suppl] 41: 3-15
23. Weyler W, Hsu Y-PP, Breakefield XO (1991) Biochemistry and genetics of monoamine oxidase. Pharmacol Ther 47: 391-417
24. Wierenga RK, Terpstra P, Hol WGJ (1986) Prediction of the occurrence of the ADP-binding βαβ-fold in proteins, using an amino acid sequence fingerprint. J Mol Biol 187: 101-107
25. Wu H-F, Chen K, Shih JC (1993) Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines. Mol Pharmacol 43: 888-893
26. Wouters J, Ramsay R, Goormaghtigh E, Ruysschaert J-M, Brasseur R, Duranr F (1995) Secondary structure of monoamine oxidase by FTIR spectroscopy. Biochem Biophys Res Commun 208: 773-778
27. Zhou BP, Lewis DA, Kwan S-W, Kirskey TJ, Abell CW (1995a) Mutagenesis of a highly conserved tyrosine residue in monoamine oxidase B affects FAD incorporation and catalytic activity. Biochemistry 34: 9526-9531
28. Zhou BP, Lewis DA, Kwan S-W, Abell CW (1995b) Flavynation of monoamine oxidase B. J Biol Chem 270: 23653-23660