A cell culture model of cerebral ischemia as a convenient system to screen for neuroprotective drugs

Journal of Neural Transmission, Supplement

Volumn , Issue 52, 1998, Pages 93-98

  Ekblom, J ^a   Garpenstrand, H ^a   Tottmar, O ^a   Prince, J A ^a   Oreland, L ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); LACTATE DEHYDROGENASE; SELEGILINE; TOLCAPONE; BENZOPHENONE DERIVATIVE; CATECHOL METHYLTRANSFERASE; ENZYME INHIBITOR; MONOAMINE OXIDASE INHIBITOR; NEUROPROTECTIVE AGENT; NITROPHENOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL AGGREGATION; CELL CULTURE; ENZYME ACTIVITY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BIOLOGICAL MODEL; CELL SURVIVAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; EMBRYO; FOREBRAIN; NERVE CELL; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; BENZOPHENONES; BRAIN ISCHEMIA; CATECHOL O-METHYLTRANSFERASE; CELL SURVIVAL; CELLS, CULTURED; EMBRYO; ENZYME INHIBITORS; L-LACTATE DEHYDROGENASE; MODELS, NEUROLOGICAL; MONOAMINE OXIDASE INHIBITORS; NEURONS; NEUROPROTECTIVE AGENTS; NITROPHENOLS; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; SELEGILINE; TIME FACTORS;

EID: 0031596687     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6499-0_11     Document Type: Article

References (10)

1. Ansari KS, Yu P, Kruck TPA, Tatton WG (1993) Rescue of axotomized immature rat facial motoneurons by R(-)-deprenyl: stereospecificity and independence from monoamine oxidase inhibition. J Neurosci 13: 4042-4053
2. Ekblom J, Aquilonius S-M, Jossan SS (1993) Differential increases in catecholamine metabolizing enzymes in amyotrophic lateral sclerosis. Exp Neurol 123: 289-294
3. Honegger P, Lenoir D, Favrod P (1979) Growth and differentiation of aggregating fetal brain cells in a serum-free defined medium. Nature 282: 305-308
4. Honegger P (1985) Biochemical differentiation in serum-free aggregating brain cell cultures. In: Bottenstein JE, Sato G (eds) Cell cultures in the neurosciences. Plenum Press, New York, pp 223-243
5. Khromoval I, Rauhala P, Zolotov N, Männistö P (1995) Tolcapone, an inhibitor of catechol-O-methyltransferase counteracts memory deficits caused by bilatral cholinotoxin lesions of the basal nuclei of Meynert. Neuroreport 6: 1219-1222
6. Lahtinen H, Koistinaho J, Kauppinen R, Haapalinna A, Keinanen R, Sivenius J (1997) Selegiline treatment after transient global ischemia in gerbils enhances the survival of CA1 pyramidal cells in the hippocampus. Brain Res 757: 260-267
7. Lowry O, Rosebrough N, Farr A, Randall R (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
8. Martinek RG (1972) A rapid ultraviolet spectrophotometric lactic dehydrogenase assay. Clin Chim Acta 40: 91
9. Moscona AA (1960) Patterns and mechanisms of tissue reconstruction from dissociated cells. In: Rudnick R (ed) Developing cell system and their control. Ronald Press, New York, pp 45-70
10. Tipton K (1995) What is it that 1-deprenyl (selegeline) might do? Clin Pharmacol Ther 56: 781-796