Metabolite analysis of [11C]flumazenil in human plasma: Assessment as the standardized value for quantitative PET studies

Annals of Nuclear Medicine

Volumn 12, Issue 1, 1998, Pages 55-59

  Ishiwata, Kiichi ^a   Itou, Takehito ^a   Ohyama, Masashi ^b   Yamada, Takamitsu ^a   Mishina, Masahiro ^b   Ishii, Kenji ^a   Nariai, Tadashi ^c   Sasaki, Toru ^a   Oda, Kei Ichi ^a   Toyama, Hinako ^a   Senda, Michio ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Benzodiazepine receptor; Human; Metabolism; PET; 11C flumazenil

Indexed keywords

BENZODIAZEPINE RECEPTOR; CARBON 11; DRUG METABOLITE; FLUMAZENIL; 4 AMINOBUTYRIC ACID A RECEPTOR; CARBON; DIAGNOSTIC AGENT; LIGAND; RADIOPHARMACEUTICAL AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; NEUROLOGIC DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TISSUE DISTRIBUTION; BLOOD; BRAIN; COMPUTER ASSISTED EMISSION TOMOGRAPHY; KINETICS; METABOLISM; MIDDLE AGED; SCINTISCANNING; STANDARD;

ADOLESCENT; ADULT; AGED; BRAIN; CARBON RADIOISOTOPES; FEMALE; FLUMAZENIL; HUMANS; KINETICS; LIGANDS; MALE; MIDDLE AGED; RADIOPHARMACEUTICALS; RECEPTORS, GABA-A; REFERENCE STANDARDS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0031596644     PISSN: 09147187     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03165418     Document Type: Article

References (16)

1. 11C]methionine in human plasma. Eur J Nucl Med 15:665-669, 1989.
2. 11C]pyrilamine. Tohoku J Exp Med 178: 129-136, 1996.
3. Pike VW, Halldin C, Crouzel C, Barrc L, Nutt DJ, Osman S, et al. Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites-current status. Nucl Med Biol 20: 503-525,1993.
4. Malizia AL, Richardson MP. Benzodiazepine receptors and positron emission tomography: ten years of experience. A new beginning? J Psychopharmacol 9: 355-368, 1995.
5. 11C-Ro 15-1788 after intravenous administration in man. Human Psychopharmacol 4: 297-301, 1989.
6. 11C]-Flumazenil metabolites: measurements of unchanged ligand in plasma using thin layer chromatography and rapid liquid chromatography. J Label Compds Radiopharm 30: 234, 1990.
7. Frey KA, Holthoff VA, Koeppe RA, Jewett DM, Kilbourn MR, Kuhl DE. Parametric in vivo imaging of benzodiazepine receptor distribution in human brain. Ann Neurol 30: 663-672, 1991.
8. 11C]Ro 15-1788 (flumazenil) from its metabolites in the blood of rabbits, baboons and humans. Appl Radiat Isot 42: 435-439, 1991.
9. 11C]Ro 15-1788 (flumazenil) in baboon and human during positron emission tomography studies. Eur J Drug Metab Pharmacokinet 16: 141-152, 1991.
10. 11C]flumazenil. Psychopharmacology 107: 180-185, 1992.
11. 11C]flumazenil kinetics studied by PET: application to a critical study of the equilibrium approaches. J Cereb Blood Flow Metab 13: 454-468, 1993.
12. 11C]RO 15-1788 for PET studies of benzodiazepine receptors. Appl Radiat hot 36; 971-976, 1985.
13. 11C]semotiadil, a benzothiazine calcium antagonist. Appl Radiat lsot 45: 439-443, 1994.
14. Iida H, Miura S, Kanno I, Murakami M, Yamamoto S, Amano M. Design and evaluation of Headtome-IV, a whole-body positron emission tomography. IEEE Trans Nucl Sci NS-37: 1006-1010, 1989.
15. 11C]flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography. J Cereb Blood Flow Metab 11: 735-744, 1991.
16. Millet P, Delforge J, Mauguiere F, Pappata S, Cinotti L, Frouin V, et al. Parameter and index images of benzodiazepine receptor concentration in the brain. J Nucl Med 36: 1462-1472, 1995.