Increased PGE2 production mediates the in vitro inhibitory effect of the human immunodeficiency virus p24 immunosuppressive heptapeptide Ch7

Scandinavian Journal of Immunology

Volumn 48, Issue 3, 1998, Pages 248-253

  Giacomini, E ^a   Giordani, L ^a   Di Modugno, F ^b   Chersi, A ^b   Luzzati, A L ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 10; PROSTAGLANDIN E2; GAG PROTEIN; IMMUNOSUPPRESSIVE AGENT; INDOMETACIN; OLIGOPEPTIDE;

ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; VIRUS INFECTION; ANTIBODY PRODUCING CELL; ANTIBODY PRODUCTION; BIOSYNTHESIS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; PHYSIOLOGY; UPREGULATION;

ANTIBODY FORMATION; ANTIBODY-PRODUCING CELLS; DINOPROSTONE; HIV CORE PROTEIN P24; HIV INFECTIONS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INDOMETHACIN; INTERLEUKIN-10; OLIGOPEPTIDES; UP-REGULATION;

EID: 0031596310     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1998.00389.x     Document Type: Article

References (36)

1. Pantaleo G, Graziosi G, Fauci AS. The immunopathogenesis of human immunodeficiency virus infection. N Engl J Med 1993;328:327-35.
2. Wei X, Ghosh SK, Taylor ME et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995;373:117-22.
3. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markovitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-6.
4. Miedema F, Meyaard L, Koot M et al. Changing virus-host interactions in the course of HIV-1 infection. Immunol Rev 1994;140:35-72.
5. Luzzati AL, Pugliese O, Giacomini E et al. Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV. Folia Biologica 1990;36:71-7.
6. Luzzati AL, Giacomini E, Giordani L, Pugliese O, Viora M, Chersi A. The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope. Immunol Lett 1992;33:307-14.
7. Luzzati AL, Giacomini E, Giordani L et al. An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex. Cell Immunol 1994;156:286-95.
8. Cordiali Fei P, Solmone M, Prignano G et al. Serum reactivity against an immunoregulatory sequence of HIV p24 in HIV-1 infected subjects. Viral Immunol 1994;7:199-203.
9. Haraguchi S, Good RA, Day NK. Immunosuppressive retroviral peptides: cAMP and cytokine patterns. Immunol Today 1995;16:595-603.
10. Phipps RP, Stein SH, Roper RL. A new view of prostaglandin E regulation of the immune response. Immunol Today 1991;12:349-52.
11. Snijdewint FGM, Kalinski P, Wierenga EA, Bos JD, Kapsenberg ML. Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J Immunol 1993;150:5321-9.
12. Ivashkiv LB, Ayres A, Glimcher LH. Inhibition of IFN-γ induction of class II MHC genes by cAMP and prostaglandins. Immunopharmacol 1994;27:67-77.
13. Longo N, Zabay JM, Sempere JM, Navarro J, Fernandez-Cruz E. Altered production of PGE2, IL-β and TNFα by peripheral blood monocytes from HIV-positive individuals at early stages of HIV infections. J AIDS 1993;6:1017-23.
14. Strassmann G, Patil-Koota V, Finkelman F, Fong M, Kambayashi T. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J Exp Med 1994;180:2365-70.
15. Platzer C, Meisel CH, Vogt K, Platzer M, Volk HD. Upregulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs. Int Immunol 1995;4:517-23.
16. Moore KW, O'Garra A, de Waal Maleyfit R, Vieira P, Mosmann TR. Interleukin 10. Annu Rev Immunol 1993;11:165-90.
17. Goldman M, Marchant A, Schandene L. Endogenous interleukin 10 in inflammatory disorders: regulatory roles and pharmacological modulation. Ann NY Acad SCi 1996;796:282-93.
18. Luzzati AL. Induction of an antibody response in cultures of human peripheral blood lymphocytes. In: Lefkovits I, Pernis B, eds. Immunological Methods, Vol. II. London, Academic Press, 1981:241-6.
19. Luzzati AL, Giacomini E, Frugoni P, Scuderi G. Central role of IL-2 signal in the induction of a specific antibody response in cultures of normal human peripheral blood lymphocytes. J Immunol Res 1989;1:183-9.
20. Versteegen JMT, Logtemberg T, Ballieux RE, Enumeration o fIFN-γ-producing lymphocytes by spot-ELISA. A method to detect lymphokine-producing lymphocytes at the single-cell level. J Immunol Methods 1988;111:25-9.
21. Luzzati AL, Boirivant M, Giacomini E, Giordani L, Di Modugno F, Chersi A. Interferon-gamma (IFN-γ) can counteract the in vitro inhibitory effect of an HIV p24 immunosuppressive heptapeptide. Clin Exp Immunol 1996;105:403-8.
22. Lacour M, Arrighi J-F, Muller KM, Carlberg C, Saurat J-H, Hauser C. cAMP, up-regulates IL-4 and IL-5 production from activated CD4+ T cells while decreasing IL-2 release and NF-AT induction. Int Immunol 1994;6:1333-43.
23. Paliogianni F, Boumpas DT. Prostaglandin E2 inhibits the nuclear transcription of the human Interleukin 2, but not the IL-4, gene in human T cells by targeting transcription factor AP-1 and NF-AT. Cell Immunol 1996;171:95-101.
24. van der Pouw Kraan TC, Boeije LC, Smeenk RJ, Wijdenes J, Aarden LA. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production. J Exp Med 1995;181:775-9.
25. Luzzati AL, Giordani L, Giacomini E. Interleukin-12 upregulates the induction of an antigen specific antibody response in cultures of human lymphocytes. Eur J Immunol 1997;27:2696-701.
26. Benbernou N, Esnault S, Shin HC, Fekkar H, Guenounou M. Differential regulation of IFN-γ, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway. Immunology 1997;91:361-8.
27. De Smedt T, Van Mechelen M, De Becker G, Urbain J, Leo O, Moser M. Effect of interleukin-10 on dendritic cell maturation and function. Eur J Immunol 1997;27:1229-35.
28. Chomarat P, Rissoan M-C, Bancherau J, Miossec P. Interferon γ inhibits interleukin 10 production by monocytes. J Exp Med 1993;177:523-7.
29. Katsikis PD, Cohen SB, Londei M, Feldman M. Are CD44+ Th1 cells pro-inflammatory or anti-inflammatory? The ratio of IL-10 to IFN-γ or IL-2 determines their function. Int Immunol 1995;7:1287-94.
30. Haraguchi S, Good RA, James-Yarish M, Cianciolo GJ. Differential modulation of Th1-and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein. Proc Natl Acad Sci 1995;92:3611-5.
31. Hilkens CM, Snijders A, Vermeulen H, van der Meide PH, Wierenga EA, Kapsenberg ML. Accessory cell derived IL-12 and prostaglandin E2 determine the IFN-γ level of activated human CD4+ T cells. J Immunol 1996;156:1722-7.
32. Libraty DH, Airan LE, Uyemura K et al. Interferon-γ differentially regulates interleukin-12 and interleukin-10 production in leprosy. J Clin Invest 1997;99:336-41.
33. Clerici M, Shearer GM. A Th1-Th2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993;14:107-11.
34. Clerici M, Wynn TA, Berzofsky JA et al. Role of interleukin 10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest 1994;93:768-75.
35. Chehimi J, Starr SE, Frank I et al. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med 1994;179:1361-66.
36. Meyaard L, Schuitemaker H, Miedema F. T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function? Immunol Today 1993;14:161-4.