An arf1Δ synthetic lethal screen identifies a new clathrin heavy chain conditional allele that perturbs vacuolar protein transport in Saccharomyces cerevisiae

Genetics

Volumn 150, Issue 2, 1998, Pages 577-589

  Chen, Chih Ying ^a   Graham, Todd R ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ALKALINE PHOSPHATASE; BETA FRUCTOFURANOSIDASE; CARBOXYPEPTIDASE C; CLATHRIN; PROTEIN; PROTEIN SWA 5; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 1; CARBOXYPEPTIDASE; CARBOXYPEPTIDASE S, S CEREVISIAE; CLATHRIN HEAVY CHAIN; GLYCOSIDASE; GUANINE NUCLEOTIDE BINDING PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CELL VACUOLE; FRAMESHIFT MUTATION; LETHAL MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; ALLELE; AMINO ACID SEQUENCE; BIOSYNTHESIS; ENZYMOLOGY; FUNGAL GENE; GENETIC COMPLEMENTATION; GENETICS; GOLGI COMPLEX; LETHAL GENE; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

SACCHAROMYCES CEREVISIAE;

ADP-RIBOSYLATION FACTOR 1; ADP-RIBOSYLATION FACTORS; ALKALINE PHOSPHATASE; ALLELES; AMINO ACID SEQUENCE; BETA-FRUCTOFURANOSIDASE; BIOLOGICAL TRANSPORT; CARBOXYPEPTIDASE C; CARBOXYPEPTIDASES; CLATHRIN; CLATHRIN HEAVY CHAINS; FRAMESHIFT MUTATION; GENES, FUNGAL; GENES, LETHAL; GENETIC COMPLEMENTATION TEST; GLYCOSIDE HYDROLASES; GOLGI APPARATUS; GTP-BINDING PROTEINS; MOLECULAR SEQUENCE DATA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; VACUOLES;

EID: 0031595549     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. BEDNAREK, S. Y., M. RAVAZZOLA, M. HOSOBUCHI, M. AMHERDT, A. PERRELET et al., 1995 COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast. Cell 83: 1183-1196.
2. BENDER, A., and J. R. PRINGLE, 1991 Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 11: 1295-1305.
3. BOMAN, A. L., T. C. TAYLOR, P. MELANCON and K. L. WILSON, 1992 A role for ADP-ribosylation factor in nuclear vesicle dynamics. Nature 358: 512-514.
4. COWLES, C. R., G. ODORIZZI, G. S. PAYNE and S. D. EMR, 1997 The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91: 109-118.
5. DELL'ANGELICA, E. C., J. KLUMPERMAN, W. STOORVOGEL and J. S. BONIFACINO, 1998 Association of the AP-3 adaptor complex with clathrin. Science 280: 431-434.
6. DONALDSON, J. G., D. FINAZZI and R. D. KLAUSNER, 1992 Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein. Nature 360: 350-352.
7. GAYNOR, E. C., and S. D. EMR, 1997 COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants. J. Cell Biol. 136: 789-802.
8. GAYNOR, E. C., S. TE HESSEN, T. R. GRAHAM, M. AEBI and S. D. EMR, 1994 Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast. J. Cell Biol. 127: 653-665.
9. GAYNOR, E. C., C.-Y. CHEN, S. D. EMR and T. R. GRAHAM, 1998 ARF is required for maintenance of yeast Golgi and endosome structure and function. Mol. Biol. Cell 9: 653-670.
10. GRAHAM, T. R., and V. A. KRASNOV, 1995 Sorting of yeast α-1,3-mannosyltransferase is mediated by a lumenal domain interaction, and a transmembrane domain signal that can confer clathrin-dependent Golgi localization to a secreted protein. Mol. Biol. Cell 6: 809-824.
11. GRAHAM, T. R., M. SEEGER, G. S. PAYNE, V. MACKAY and S. D. EMR, 1994 Clathrin-dependent localization of α1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae. J. Cell Biol. 127: 667-678.
12. HELMS, J. B., and J. E. ROTHMAN, 1992 Inhibition by brefeldin A of a Golgi membrane enzyme that catalyzes exchange of guanine nucleotide bound to ARF. Nature 360: 352-354.
13. HEUSER, J., and C. J. STEER, 1989 Trimeric binding of the 70-kD uncoating ATPase to the vertices of clathrin triskelia: a candidate intermediate in the vesicle uncoating reaction. J. Cell Biol. 109: 1457-1466.
14. HORAZDOVSKY, B. F., G. R. BUSCH and S. D. EMR, 1994 VPS21 encodes a rab5-Iike GTP binding protein that is required for the sorting of yeast vacuolar proteins. EMBO J. 13: 1297-1309.
15. JOHNSON, L. M., V. A. BANKAITIS and S. D. EMR, 1987 Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protein. Cell 48: 875-885.
16. KAHN, R. A., J. CLARK, C. RULKA, T. STEARNS, C. J. ZHANG et al., 1995 Mutational analysis of Saccharomyces cerevisiae ARF1. J. Biol. Chem. 270: 143-150.
17. KOOY, J., B. H. TOH, J. M. PETTITT, R. ERLICH and P. A. GLEESON, 1992 Human autoantibodies as reagents to conserved Golgi components: characterization of a peripheral, 230-kDa compartment-specific Golgi protein. J. Biol. Chem. 267: 20255-20263.
18. KOSHLAND, D., J. C. KENT and L. H. HARTWELL, 1985 Genetic analysis of the mitotic transmission of minichromosomes. Cell 40: 393-403.
19. KRANZ, J. E., and C. HOLM, 1990 Cloning by function: an alternative approach for identifying yeast homologs of genes from other organisms. Proc. Natl. Acad. Sci. USA 87: 6629-6633.
20. KTISTAKIS, N. T., H. A. BROWN, M. G. WATERS, P. C. STERNWEIS and M. G. ROTH, 1996 Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles. J. Cell Biol. 134: 295-306.
21. LATHE, R., J. L. VILOTTE and A. J. CLARK, 1987 Plasmid and bacteriophage vectors for excision of intact inserts. Gene 57: 193-201.
22. LAWRENCE, C. W., 1991 Classical mutagenesis techniques. Methods Enzymol. 194: 273-281.
23. LEMMON, S., V. P. LEMMON and E. W. JONES, 1988 Characterization of yeast clathrin and anticlathrin heavy-chain monoclonal antibodies. J. Cell. Biochem. 36: 329-340.
24. LEMMON, S. K., C. FREUND, K. CONLEY and E. W. JONES, 1990 Genetic instability of clathrin-deficient strains of Saccharomyces cerevisiae. Genetics 124: 27-38.
25. LEMMON, S. K., A. PELLICENA-PALLE, K. CONLEY and C. L. FREUND, 1991 Sequence of the clathrin heavy chain from Saccharomyces cerevisiae and requirement of the COOH terminus for clathrin function. J. Cell Biol. 112: 65-80.
26. LENHARD, J. M., R. A. KAHN and P. D. STAHL, 1992 Evidence for ADP-rihosylation factor (ARF) as a regulator of in vitro endosome-endosome fusion. J. Biol. Chem. 267: 13047-13052.
27. LIU, S. H., M. L. WONG, C. S. CRAIK and F. M. BRODSKY, 1995 Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs. Cell 83: 257-267.
28. MISUMI, Y., M. SOHDA, A. YANO, T. FUJIWARA and Y. IKEHARA, 1997 Molecular characterization of GCP170, a 170-kDa protein associated with the cytoplasmic face of the Golgi membrane. J. Biol. Chem. 272: 23851-23858.
29. MORINAGA, N., S. C. TSAI, J. MOSS and M. VAUGHAN, 1996 Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain. Proc. Natl. Acad. Sci. USA 93: 12856-12860.
30. PANEK, H. R., J. D. STEPP, H. M. ENGLE, K. M. MARKS, P. K. TAN et al., 1997 Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four summits of a novel clathrin AP-like complex. EMBO J. 16: 4194-4204.
31. PAYNE, G. S., and R. SCHEKMAN, 1989 Clathrin: a role in the intracellular retention of a Golgi membrane protein. Science 245: 1358-1365.
32. PAYNE, G. S., T. B. HASSON, M. S. HASSON and R. SCHEKMAN, 1987 Genetic and biochemical characterization of clathrin-deficient Saccharomyces cerevisiae. Mol. Cell. Biol. 7: 3888-3898.
33. PAYNE, G. S., D. BAKER, E. VAN TUINEN and R. SCHEKMAN, 1988 Protein transport to the vacuole and receptor-mediated endocytosis by clathrin heavy chain-deficient yeast. J. Cell Biol. 106: 1453-1461.
34. PEYROCHE, A., S. PARIS and C. L. JACKSON, 1996 Nucleotide exchange on ARF mediated by yeast Geal protein. Nature 384: 479-481.
35. PIPER, R. C., N. J. BRYANT and T. H. STEVENS, 1997 The membrane protein alkaline phosphatase is delivered to the vacuole by a route that is distinct from the VPS-dependent pathway. J. Cell Biol. 138: 531-545.
36. PODOS, S. D., P. REUDY, J. ASHKENAS and M. KRIEGER, 1994 LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function. J. Cell Biol. 127: 679-691.
37. POON, P. P., X. WANG, M. ROTMAN, I. HUBER, E. CUKIERMAN et al., 1996 Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein. Proc. Natl. Acad. Sci. USA 93: 10074-10077.
38. ROBINSON, J. S., D. J. KLIONSKY, L. M. BANTA and S. D. EMR, 1988 Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol. Cell. Biol. 8: 4936-4948.
39. ROBINSON, M. S., and T. E. KREIS, 1992 Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: effects of brefeldin A and G protein activators. Cell 69: 129-138.
40. ROTHSTEIN, R., 1991 Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194: 281-301.
41. SCHEKMAN, R., and L. ORCI, 1996 Coat proteins and vesicle budding. Science 271: 1526-1533.
42. SEAMAN, M. N., C. L. BALL and M. S. ROBINSON, 1993 Targeting and mistargeting of plasma membrane adaptors in vitro. J. Cell Biol. 123: 1093-1105.
43. SEEGER, M., and G. S. PAYNE, 1992a A role for clathrin in the sorting of vacuolar proteins in the Golgi complex of yeast. EMBO J. 11: 2811-2818.
44. SEEGER, M., and G. S. PAYNE, 1992b Selective and immediate effects of clathrin heavy chain mutations on Golgi membrane protein retention in Saccharomyces cerevisiae. J. Cell Biol. 118: 531-540.
45. SHERMAN, F., 1991 Guide to yeast genetics and molecular biology. Methods Enzymol. 194: 3-21.
46. SIKORSKI, R. S., and J. D. BOEKE, 1991 In vitro mutagenesis and plasmid shuffling: from cloned gene to mutant yeast. Methods Enzymol. 194: 302-318.
47. SIKORSKI, R. S., and P. HIETER, 1989 A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
48. SIMPSON, F., N. A. BRIGHT, M. A. WEST, L. S. NEWMAN, R. B. DARNELL et al., 1996 A novel adaptor-related protein complex. J. Cell Biol. 133: 749-760.
49. STAMNES, M. A., and J. E. ROTHMAN, 1993 The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein. Cell 73: 999-1005.
50. STEARNS, T., R. A. KAHN, D. BOTSTEIN and M. A. HOYT, 1990a ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes. Mol. Cell. Biol. 10: 6690-6699.
51. STEARNS, T., M. C. WILLINGHAM, D. BOTSTKIN and R. A. KAHN, 1990b ADP-ribosylation factor is functionally and physically associated with the Golgi complex. Proc. Natl. Acad. Sci. USA 87: 1238-1242.
52. STEPP, J. D., K. HUANG and S. K. LEMMON, 1997 The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. J. Cell Biol. 139: 1761-1774.
53. STEVENS, T., B. ESMON and R. SCHEKMAN, 1982 Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole. Cell 30: 439-448.
54. TAN, P. K., N. G. DAVIS, G. F. SPRAGUE and G. S. PAYNE, 1993 Clathrin facilitates the internalization of seven transmembrane segment receptors for mating pheromones in yeast. J. Cell Biol. 123: 1707-1716.
55. TRAUB, L. M., and S. KORNFELD, 1997 The trans-Golgi network: a late secretory sorting station. Curr. Opin. Cell Biol. 9: 527-533.
56. TRAUB, L. M., J. A. OSTRAM and S. KORNFELD, 1993 Biochemical dissection of AP-1 recruitment onto Golgi membranes. J. Cell Biol. 123: 561-573.
57. VOWELS, J. J., and G. S. PAYNE, 1998 A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole. EMBO J. 17: 2482-2493.
58. WHITNEY, J. A., M. GOMEZ, D. SHEFF, T. E. KREIS and I. MELLMAN, 1995 Cytoplasmic coat proteins involved in endosome function. Cell 83: 703-713.
59. WONG, D. H., and F. M. BRODSKY, 1992 100-kD proteins of Golgiand trans-Golgi network-associated coated vesicles have related but distinct membrane binding properties. J. Cell Biol. 117: 1171-1179.