α2-Heremans Schmid glycoprotein inhibits insulin-stimulated elk-1 phosphorylation, but not glucose transport, in rat adipose cells

Endocrinology

Volumn 139, Issue 10, 1998, Pages 4147-4154

  Chen, Hui ^a   Srinivas, Pothur R ^b   Cong, Li Na ^a   Li, Yunhua ^a   Grunberger, George ^b   Quon, Michael J ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PROTEIN KINASE; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; ALPHA2HS GLYCOPROTEIN; DNA BINDING PROTEIN; ELK1 PROTEIN, RAT; GLUCOSE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR; MUSCLE PROTEIN; ONCOPROTEIN; PLASMA PROTEIN; SLC2A4 PROTEIN, RAT; TRANSCRIPTION FACTOR ELK 1; TYROSINE;

ADIPOSE TISSUE CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ENZYME ACTIVITY; GLUCOSE TRANSPORT; INSULIN BLOOD LEVEL; MINERALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; TARGET CELL; ADIPOCYTE; ANIMAL; DRUG EFFECT; GENETIC TRANSFECTION; MALE; METABOLISM; PHOSPHORYLATION; TRANSPORT AT THE CELLULAR LEVEL;

ADIPOCYTES; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; DNA-BINDING PROTEINS; ETS-DOMAIN PROTEIN ELK-1; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; MALE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; RATS; RECEPTOR, INSULIN; TRANSCRIPTION FACTORS; TRANSFECTION; TYROSINE;

EID: 0031595066     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.10.6258     Document Type: Article

References (34)

1. Dziegielewska KM, Brown WM 1995 Fetuin. Springer-Verlag, Heidelberg
2. 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Mol Endocrinol 7:1445-1455
3. 2-HS glycoprotein inhibits insulin-stimulated mitogenic pathway without affecting metabolic signalling in Chinese hamster ovary cells overexpressing the human insulin receptor. Cell Signal 8:567-573
4. 2-HS glycoprotein is a transforming growth factor-β type II receptor mimic and cytokine antagonist. J Biol Chem 271:12755-12761
5. Ohnishi T, Nakamura O, Arakaki N, Daikuhara Y 1997 Effect of phosphorylated rat fetuin on the growth of hepatocytes in primary culture in the presence of human hepatocyte-growth factor. Evidence that phosphorylated fetuin is a natural modulator of hepatocyte-growth factor. Eur J Biochem 243:753-761
6. Cayatte AJ, Kumbla L, Subbiah MT 1990 Marked acceleration of exogenous fatty acid incorporation into cellular triglycerides by fetuin. J Biol Chem 265:5883-5888
7. Kumbla L, Bhadra S, Subbiah MT 1991 Multifunctional role for fetuin (fetal protein) in lipid transport. FASEB J 5:2971-2975
8. van Oss Q, Gillman CF, Bronson PM, Border JR 1974 Opsonic properties of human scrum α-2 hs glycoprotein. Immunol Commun 3:329-335
9. van Oss CJ, Gillman CF, Bronson PM, Border JR 1974 Phagocytosis-inhibiting properties of human serum α-1 acid glycoprotein. Immunol Commun 3:321-328
10. 2HS) in human embryonic and fetal development. Cell Tissue Res 248:33-41
11. 2HS glycoprotein in mineralising human bone. Nature 256:430-432
12. 2HS-glycoprotein and its accumulation in bone. Nature 262:226-227
13. 2HS-glycoprotein modulates in vitro bone resorption. J Clin Endocrinol Metab 66:187-192
14. 2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells. A possible role in mineralization and calcium homeostasis. J Biol Chem 271:20789-20796
15. Jahnen-Dechent W, Schinke T, Trindl A, Muller-Esterl W, Sablitzky F, Kaiser S, Blessing M 1997 Cloning and targeted deletion of the mouse fetuin gene. J Biol Chem 272:31496-31503
16. Schinke T, Koide T, Jahnen-Dechent W 1997 Human histidine-rich glycoprotein expressed in SF9 insect cells inhibits apatite formation. FEBS Lett 412:559-562
17. Auberger P, Falquerho L, Contreres JO, Pages G, Le Cam G, Rossi B, Le Cam A 1989 Characterization of a natural inhibitor of the insulin receptor tyrosine kinase: cDNA cloning, purification, and anti-mitogenic activity. Cell 58:631-640
18. Rauth G, Poschke O, Fink E, Eulitz M, Tippmer S, Kellerer M, Haring HU, Nawratil P, Haasemann M, Jahnen-Dechent W, Muller-Esterl W 1992 The nucleotide and partial amino acid sequences of rat fetuin. Identity with the natural tyrosine kinase inhibitor of the rat insulin receptor. Eur J Biochem 204:523-529
19. Mathews ST, Srinivas PR, Leon MA, Grunberger G 1997 Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase. Life Sci 61:1583-1592
20. Quon MJ, Butte AJ, Taylor SI 1994 Insulin signal transduction pathways. Trends Endocrinol Metab 5:369-376
21. 2-HS glycoprotein-like molecule, but is it the tyrosine kinase inhibitor pp63? Cell 68:7-8
22. Le Cam A, Auberger P, Falquerho L, Contreres JO, Pages G, Le Cam G, Rossi B 1992 pp63 is very likely rat fetuin. Cell 68:7-8
23. Akhoundi C, Amiot M, Auberger P, Le Cam A, Rossi B 1994 Insulin and interleukin-1 differentially regulate pp63, an acute phase phosphoprotein in hepatoma cell line. J Biol Chem 269:15925-15930
24. 2-HS glycoprotein (human fetuin). Evidence for the production of a phosphorylated single-chain form by hepatoma cells. Eur J Biochem 226:59-69
25. Quon MJ, Zamowski MJ, Guerre-Millo M, de la Luz Sierra M, Taylor SI, Cushman SW 1993 Transfection of DNA into isolated rat adipose cells by electroporation: evaluation of promoter activity in transfected adipose cells which are highly responsive to insulin after one day in culture. Biochem Biophys Res Commun 194:338-346
26. 1153→Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc Natl Acad Sci USA 91:5587-5591
27. Karnieli E, Zarnowski MJ, Hissin PJ, Simpson IA, Salans LB, Cushman SW 1981 Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity. J Biol Chem 256:4772-4777
28. Quon MJ, Chen H, Ing BL, Liu ML, Zarnowski MJ, Yonezawa K, Kasuga M, Cushman SW, Taylor SI 1995 Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells. Mol Cell Biol 15:5403-5411
29. Chen H, Wertheimer SJ, Lin CH, Katz SL, Amrein KE, Burn P, Quon MJ 1997 Protein-tyrosine phosphatases PTPlB and Syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. J Biol Chem 272:8026-8031
30. Cushman SW, Salans LB 1978 Determinations of adipose cell size and number in suspensions of isolated rat and human adipose cells. J Lipid Res 19:269-273
31. Cong L, Chen H, Li Y, Zhou L, McGibbon MA, Taylor SI, Quon MJ 1997 Physiological role for Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol 11:1881-1890
32. Srinivas PR, Goustin AS, Grunberger G 1995 Baculoviral expression of a natural inhibitor of the human insulin receptor tyrosine kinase. Biochem Biophys Res Commun 208:879-885
33. Quon MJ, Butte AJ, Zarnowski MJ, Sesti G, Cushman SW, Taylor SI 1994 Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells. J Biol Chem 269:27920-27924
34. Zhou L, Chen H, Lin CH, Cong L, McGibbon MA, Sciacchitano S, Lesniak MA, Quon MJ, Taylor SI 1997 Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin to stimulate translocation of GLUT4 to the cell surface in rat adipose cells. J Biol Chem 272:29829-29833