Effects of mesaconitine on [3H]noradrenaline uptake and neuronal excitability in rat hippocampus

Experimental Brain Research

Volumn 121, Issue 4, 1998, Pages 451-456

  Ameri, Angela ^a   Seitz, Ulrike ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Hippocampus; Mesaconitine; Noradrenaline; Population spike; Uptake

Indexed keywords

DESIPRAMINE; MESACONITINE; NORADRENALIN; PROPRANOLOL; TIMOLOL; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ACONITINE; AMINO ACID RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIAGNOSTIC AGENT; DRUG DERIVATIVE; TRITIUM;

ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HIPPOCAMPUS; MALE; NERVE EXCITABILITY; NEUROTRANSMITTER UPTAKE; NONHUMAN; NORADRENERGIC SYSTEM; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; SYNAPTOSOME; ACTION POTENTIAL; ANIMAL; CYTOLOGY; DRUG EFFECT; ELECTROPHYSIOLOGY; NERVE CELL; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; WISTAR RAT;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ACONITINE; ACTION POTENTIALS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; MALE; NEURONS; NOREPINEPHRINE; ORGAN CULTURE TECHNIQUES; PROPRANOLOL; RATS; RATS, WISTAR; TRITIUM;

EID: 0031594854     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210050480     Document Type: Article

References (27)

1. Ameri A, Shi Q, Aschoff J, Peters T (1996) Electrophysiological effects of aconitine in rat hippocampal slices. Neuropharmacology 35:13-22
2. Bolden-Watson C, Richelson E (1983) Blockade by newly-developed antidepressants of biogenic amine uptake into rat brains synaptosomes. Life Sci 52:1023-1029
3. 3H-noradrenaline from adrenergic nerve of the vas deferens. Naunyn-Schmiedebergs Arch Pharmacol 336:621-630
4. Bönisch H, Graefe KH, Keller B (1983) Tetrodotoxin-sensitive and -resistant effects of veratridine on the noradrenergic neurone of the rat vas deferens. Naunyn-Schmiedebergs Arch Pharmacol 324:264-270
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein dye binding. Anal Biochem 72:248-254
6. Catterall WA (1980) Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu Rev Pharmacol Toxicol 20:15-43
7. Cutterall WA (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 72:15-48
8. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108
9. Dunwiddie TV (1986) The use of in vitro brain slices in neuropharmacology. In: Dunwiddie TV (ed) Electrophysiological techniques in pharmacology. Liss, New York, pp 65-90
10. Dunwiddi TV, Taylor M, Heginbotham LR, Proctor WR (1992) Long-term increases in excitability in the CA1 region of rat hippocampus induced by β-adrenergic stimulation: possible mediation by cAMP. J Neurosci 12:506-517
11. Haas HL, Konnerth A (1983) Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells. Nature 302:432-434
12. Hikino H, Murayahama M (1985) Mechanisms of the antinociceptive action of mesoconitine: participation of brain stem and lumbar enlargement. Br J Pharmacol 85:575-580
13. Hikino H, Takata H, Fujiwara M, Konno C, Ohuchi K (1982) Mechanism of inhibitory action of mesaconitine in acute inflammations. Eur J Pharmacol 82:65-71
14. Isono T, Oyama T, Asami A, Suzuki Y, Hayakawa Y, Ikeda Y, Noguchi M, Omiya Y (1994) The analgesic mechanism of processed aconiti tuber: involvement of descending inhibitory system. Am J Chinese Med 22:83-94
15. Kostopoulos G, Psarropulou C, Haas HL (1988) Membrane properties, response to amines and to tetanic stimulation of hippocampal neurons in the genetically epileptic mutant mouse tottering. Exp Brain Res 72:45-50
16. Madison DV, Nicoll RA (1982) Noradrenaline provides accommodation of pyrmidal cell discharge in the hippocampus. Nature 299:636-638
17. Madison DV, Nicoll RA (1986a) Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones in vitro. J Physiol (Lond) 372:221-224
18. Madison DV, Nicoll RA (1986b) Cyclic adenosine 3′,5′-monophosphate mediates β-receptor actions of noradrenaline in rat hippocampal pyramidal cells. J Physiol (Lond) 372:245-259
19. Madison DV, Nicoli RA (1988) Norepinephrine decreases synaptic inhibition in the rat hippocampus. Brain Res 442:131-138
20. Mueller AL, Hoffer BJ, Dunwiddie TV (1981) Noradrenergic responses in rat hippocampus: evidence for mediation by α and β receptors in the in vitro slice. Brain Res 214:113-126
21. Nicoll RA, Malenka RC, Kauer JA (1990) Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system. Physiol Rev 70:513-565
22. Olpe OR, Laszlo J, Pozza MF, DeHerdt P, Waldmeier PC, Jones RSG (1986) Glutamate-induced activation of rat locus coeruleus increases CA1 pyramidal cell excitability. Neurosci Lett 65:11-16
23. Petterson E (1995) Studies of four diphenylbutylpiperazinepyridyl derivatives on release and inhibition of reuptake of dopamine, serotonin and noradrenaline by rat brain in vitro. Eur J Pharmacol 282:131-135
24. Sato H, Ohizumi Y, Hikino H (1979) Mechanism of mesaconitine-induced contractile response in guinea pig vas deferens. Eur J Pharmacol 55:83-92
25. Stantoford SC (1996) Prozac: panacea or puzzle? Trends Pharmacol Sci 17:150-154
26. Suzuki J, Oyama T, Ishige A, Isono T, Asami A, Ikeda Y, Noguchi M, Omiya Y (1994) Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconitine. Planta Med 60:391-394
27. Thomas MJ, Moody TD, Makhinson M, O'Dell TJ (1996) Activity-dependent β-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region. Neuron 17:475-482