Serotonin (5-HT1A-Receptor) Agonist-Induced Collecting Duct Vacuolation and Renal Papillary Necrosis in the Rat

Toxicologic Pathology

Volumn 26, Issue 1, 1998, Pages 152-159

  Rinke, Matthias ^a   Bomhard, Ernst M ^a   Hildebrand, Heinz ^a   Leser, Karl H ^a   Loof, Ingo ^a   Ruehl Fehlert, Christine ^a  

^a BAYER AG   (Germany)

Author keywords

azaspirodecanedions; Brattleboro rat; Kidney; renal medulla; species specific; vacuolar swelling; Wistar rat

Indexed keywords

2 BROMOETHYLAMINE; 2-BROMOETHYLAMINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ARGIPRESSIN; ETHYLAMINE; IPSAPIRONE; PYRIMIDINE DERIVATIVE; SEROTONIN AGONIST; ANXIOLYTIC AGENT; ENDOTHELIN; PROSTAGLANDIN E2; SEROTONIN 1A AGONIST;

ADULT; ANIMAL; ARTICLE; BODY WEIGHT; BRATTLEBORO RAT; CELL VACUOLE; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; DRUG EFFECT; ENZYMOLOGY; EPITHELIUM CELL; FEMALE; HUMAN; KIDNEY COLLECTING TUBULE; KIDNEY MEDULLA; KIDNEY PAPILLA NECROSIS; LIVER; MALE; METABOLISM; PATHOLOGY; PHASE 1 CLINICAL TRIAL; RAT; SPECIES DIFFERENCE; WISTAR RAT; ANIMAL CELL; ANIMAL TISSUE; CONFERENCE PAPER; HISTOPATHOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SURVIVAL RATE; URINARY EXCRETION;

ADULT; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ARGININE VASOPRESSIN; BODY WEIGHT; EPITHELIAL CELLS; ETHYLAMINES; FEMALE; HUMANS; KIDNEY MEDULLA; KIDNEY PAPILLARY NECROSIS; KIDNEY TUBULES, COLLECTING; LIVER; MALE; PYRIMIDINES; RATS; RATS, BRATTLEBORO; RATS, WISTAR; SEROTONIN AGONISTS; SPECIES SPECIFICITY; VACUOLES;

EID: 0031594610     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339802600118     Document Type: Article

References (30)

1. Bach PH and Bridges JW (1985). Chemical induced renal papillary necrosis and upper urothelial carcinoma. Crit. Rev. Toxicol. 15: 217-411.
2. Bach PH and Kwizera EN (1988). Nephrotoxicity: A rational approach to target cell injury in vitro in the kidney. Xenobiotica 18: 685-698.
3. Boyce JT, DiBartola SP, Chew DJ, and Gasper PW (1984). Familial renal amyloidosis in Abyssinian cats. Vet. Pathol. 21: 33-38.
4. Burry A (1978). Pathology of analgesic nephropathy: Australian experience. Kidney Int. 13: 34-40.
5. Carlton WW and Engelhardt JA (1989). Experimental renal papillary necrosis in the Syrian hamster. Food Chem. Toxicol. 27: 331-340.
6. Eknoyan G, Qunibi WY, Grissom RT, and Ayus JC (1982). Renal papillary necrosis: An update. Medicine 61: 55-73.
7. Elliott GA (1986). Papillary necrosis, rat. In: Monographs on Pathology of Laboratory Animals, Urinary System. TC Jones, U Mohr, and RD Hunt (eds). Springer-Verlag, Berlin, pp. 184–189.
8. Evan AP and Gardner KD (1976). Comparison of human polycystic and medullary cystic kidney disease with diphenylamine-induced cystic disease. Lab. Invest. 35: 93-101.
9. Fuwa M and Waugh D (1968). Experimental papillary necrosis: Effects of diuresis and antidiuresis. Arch. Pathol. 85: 404-409.
10. Goldberg HL (1984). Benzodiazepine and nonbenzodiazepine anxiolytics. Psychopathology 17: 45-55.
11. Gunson DE (1983). Papillary necrosis in horses. J. Am. Vet. Med. Assoc. 182: 263-266.
12. Hansen GP, Tisher CC, and Robinson RR (1980). Response of the collecting duct to disturbances of acid-base and potassium balance. Kidney Int. 17: 326-337.
13. Hardy TL and Bach PH (1984): The effect of N-phenyanthranilic acid-induced renal papillary necrosis on urinary acidification and renal electrolyte handling. Toxicol. Appl. Pharmacol. 75: 265-277.
14. Hildebrand H, Bomhard EM, Leser KH, Rinke M, Schoellnhammer G, Sundaresan P, and Schlueter G (1993). Ipsapirone induces increased urinary excretion of endothelin in rat but not in man–-Correlation with renal alterations. European Science Foundation Meeting, Sitges, Spain (poster).
15. Koe BK (1979). Biochemical effects of antianxiety drugs on brain monamines. In: Anxiolytics, S Fielding and H Lal (eds). Futura Publishing Company, Mount Kisco, New York, pp. 173–195.
16. Kriz W (1967). Architectural and functional structure of the rat kidney. Z Zellforsch. Mikrosk. Anat. 82: 495-535 (in German).
17. Lenz SD and Carlton WW (1990). Diphenylamine-induced renal papillary necrosis and necrosis of pars recta in laboratory rodents. Vet. Pathol. 27: 171-178.
18. Leser KH, Bomhard EM, Luckhaus G, Rinke M, Schmidt B, and Schlueter G (1993). Renal alterations induced by 5HT1A-receptor agonists. 32nd Annual Meeting Society of Toxicology, New Orleans (abstract no. 744). Toxicologist 13: 203.
19. Molland EA (1978). Experimental renal papillary necrosis. Kidney Int. 13: 5-14.
20. Muehrcke RC and Rosen S (1954). Hypokalemic nephropathy in rat and man: A light and electron-microscopic study. Lab. Invest. 13: 1359-1373.
21. Oliver J, MacDowell M, Welt LG, Holliday MA, Hollander W Jr, Winters RW, Williams TF, and Segar WE (1957). The renal lesions of electrolyte imbalance. I. The structural alterations in potassium-depleted rats. J. Exp. Med. 106: 563-574.
22. Peroutka S (1965). Selective interaction of novel anxiolytics with 5-hydroxytryptamine 1A receptors. Biol. Psychiatry 20: 971-979.
23. Powell CJ, Adams T, Hall DE, Bach PH, and Bridges JW (1985). The comparative subacute nephrotoxicity of diphenlyamine and N-phenyanthranilic acid. In: Renal Heterogenity and Target Cell Toxicity. John Wiley & Sons, Chichester, UK, pp. 199–202.
24. Rosenbaum JF (1982). The drug treatment of anxiety. N. Engl. J. Med. 306: 401-404.
25. Strange K (1991). Volume regulatory CI– loss after Na+ pump inhibition in CCT principle cells. Am. J. Physiol. 260: F225–F234.
26. Toback FG, Ordonez NG, Bortz SL, and Spargo BH (1976). Zonal changes in renal structure and phospholipid metabolism in potassium-deficient rats. Lab. Invest. 34: 115-124.
27. Wanke R (1986): Toxic tubular necrosis with papillary necrosis in dogs. Tierarzll. Umsch. 41: 460-467.
28. Wolf DC, Lenz SD, and Carlton WW (1991). Renal papillary necrosis in two domestic cats and a tiger. Vet. Pathol. 28: 84-87.
29. Zeidel ML, Brady HR, Kone BC, Gullans SR, and Brenner BM (1989). Endothelin, a peptide inhibitor of Na+-K+-ATPase in intact renal tubular epithelial cells. Am J. Physiol. 257: C1101–C1107.
30. Zwicker GM, Gosselin SJ, Solomon JL, and Hurst GH (1996). Effects found in a one-year oral toxicity study in Sprague-Dawley rats of a novel 5-HT1A receptor partial agonist for the treatment of anxiety in humans. Toxicol. Pathol. 24: 207-213.