Effects Found in a One-Year Oral Toxicity Study in Sprague-Dawley Rats of a Novel 5-HT1A Receptor Partial Agonist for the Treatment of Anxiety in Humans

Toxicologic Pathology

Volumn 24, Issue 2, 1996, Pages 207-213

  Zwicker, G M ^a   Gosselin, S J ^a   Solomon, J L ^a   Hurst, G H ^a  

^a Marion Merrell Dow Inc   (United States)

Author keywords

anxiolytic; bioavailability; endocrine; estrogenic; metabolism; morphology; Serotonin

Indexed keywords

8 [2 [(2,3 DIHYDRO 1,4 BENZODIOXIN 2 YL)METHYLAMINO]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE MESYLATE; SEROTONIN 1A AGONIST;

ADRENAL HYPERPLASIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS LUTEUM; DIESTRUS; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; ENDOMETRIUM; FEMALE; HYPERPLASIA; HYPOPHYSIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SQUAMOUS CELL METAPLASIA; UTERUS WEIGHT; WEIGHT REDUCTION;

ANIMALS; ANTI-ANXIETY AGENTS; BIOLOGICAL AVAILABILITY; BODY WEIGHT; DIOXINS; EATING; FEMALE; HUMANS; MALE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN AGONISTS; SEX CHARACTERISTICS; SPIRO COMPOUNDS;

ANIMALIA;

EID: 0029985799     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339602400209     Document Type: Article

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