Manoalide, a phospholipase A2 inhibitor, inhibits arachidonate incorporation and turnover in brain phospholipids of the awake rat

Neurochemical Research

Volumn 23, Issue 10, 1998, Pages 1251-1257

  Grange, Eric ^a   Rabin, Olivier ^a   Bell, Jane ^a   Chang, Michael C J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Arachidonic acid; Awake; Fatty acids; In vivo; Inhibition; Manoalide; Phospholipase A2; Phospholipids; Rat; Turnover

Indexed keywords

ACYL COENZYME A; ARACHIDONIC ACID; ARACHIDONOYL COENZYME A; CALCIUM; CARBON 14; EDETIC ACID; LIPID; MANOALIDE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPASE C; PHOSPHOLIPID; TRIACYLGLYCEROL; TRITIUM; ARACHIDONYL-COENZYME A; ENZYME INHIBITOR; PHOSPHOLIPASE A; TERPENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; ENZYME INHIBITION; INTRAVENOUS DRUG ADMINISTRATION; LIPID BRAIN LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WAKEFULNESS; ANIMAL; BIOLOGICAL MODEL; BRAIN; DRUG ANTAGONISM; DRUG EFFECT; FISCHER 344 RAT; METABOLISM;

ANIMALIA; TRITIUM;

ACYL COENZYME A; ANIMALS; ARACHIDONIC ACID; BRAIN; ENZYME INHIBITORS; MALE; MODELS, BIOLOGICAL; PHOSPHOLIPASES A; PHOSPHOLIPIDS; RATS; RATS, INBRED F344; TERPENES; WAKEFULNESS;

EID: 0031593893     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020788031720     Document Type: Article

References (35)

1. Irvine, R. F. 1982. How is the level of free arachidonic acid controlled in mammalian cell? Biochem J. 204:3-16.
2. Needleman, P., Turk, J., Jakschik, B. A., Morrisson, A. R., and Lefkowith, J. B. 1986. Arachidonic acid metabolism. Annu. Rev. Biochem. 55:69-102.
3. Sun, G.Y., and MacQuarrie, R. A. 1989. Deacylation-reacylation of arachidonoyl groups in cerebral phospholipids. Ann. NY Acad. Sci. 559:37-55.
4. Prescott, S. M., and Majerus, P. W. 1981. The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets. J. Biol Chem. 756:579-582.
5. 3H]arachidonate in the anesthetized rat. J. Neurochem. 63:727-736.
6. Nariai, T., DeGeorge, J. J., Greig, N. H., Genka, S., Rapoport, S. I., and Purdon, A. D. 1994. Differences in rates of incorporation of intravenously injected radiolabeled fatty acids into phospholipids of intracerebrally implanted tumor and brain in awake rats. Clin. Exp. Metastasis 12:213-225.
7. Piomelli, D. 1993. Arachidonic acid in cell signaling. Curr. Opin. Cell Biol. 5:274-280.
8. 2 inhibition by manoalide: A novel type of phospholipase inhibitor. J. Biol. Chem. 260:7234-7240.
9. Grange, E., Chang, M. C., Rabin, O., Bell, J., and Rapoport, S. I. 1995. Effect of a phospholipase A2 inhibitor on arachidonate incorporation into brain lipids in vivo. Trans. Am. Soc. Neurochem. 64:S 11.
10. Grange, E., Deutsch, J., Smith, Q. R., Chang, M. C., Rapoport, S. I., and Purdon, A. D. 1995. Specific activity of brain palmitoyl-CoA provides rates of incorporation of palmitate in brain phospholipids in awake rats. J. Neurochem. 65:2290-2298.
11. Folch, J., Lees, M., and Stanley, G. H. S. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497-509.
12. Skipski, V. P., Good, J. J., Barklay, M., and Reggio, R. B. 1968. Quantitative analysis of simple lipid classes by thin-layer chromatography. Biochim. Biophys. Acta 152:10-19.
13. Robinson P. J., Noronha J., DeGeorge, J. J., Freed, L. M., Nariai, T., and Rapoport, S. I. 1992. A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res. Rev. 17:187-214.
14. Chang, M. C. J., Grange, E., Rabin, O., Bell, J. M., Allen, D. D., and Rapoport, S. I. 1996. Lithium decreases turnover of arachidonate in several brain phospholipids. Neurosci. Lett. 220:171-174. Erratum 222:141.
15. Deutsch, J., Grange, E., Rapoport, S. I., and Purdon, A. D. 1994. Isolation and quantification of acyl-CoA esters in brain tissue by solid phase extraction. Anal. Biochem. 220:321-323.
16. 2 in homogenate of sea urchin sperm by delta-9-tetrahydrocannabinol. Biochem. Pharmacol. 42:899-904.
17. 2 activity. Neurochem. Res. 23: 887-892.
18. 2 from bovine brain cytosol. J. Neurochem. 59:708-714.
19. 2 from cytosol to membranes in rat brain induced by calcium ions. Biochem. Biophys. Res. Commun. 170:484-490.
20. Waite, M. 1987. Handbook of Lipid Research: Vol 5, The Phospholipases. Plenum Press. New York.
21. Perret, B., Chap, H. J., and Douste-Blazy, L. 1979. Asymmetric distribution of arachidonic acid in the plasma membrane of human platelets. A determination using purified phospholipases and a rapid method for membrane isolation. Biochim. Biophys. Acta. 556:434-446.
22. 2+-dependent translocation domain with homology to PKC and GAP. Cell 65:1043-1051.
23. 2. J. Biochem. 111:54-60.
24. 2 in rat tissue cytosols. Biochem. Biophys. Acta 962:345-353.
25. 2(s); comparaison of arachidonoyl-selective and non selective enzymes. FASEB J. 7, 339-348.
26. 2) is the major isoform in vertebrate brain and expressed in the limbic system. Trans. Am. Soc. Neurosci. 22 (1996) 620.
27. 2) is expressed in human brain astrocytes. Brain Res. 637:97-105.
28. Bennett, C. F., Mong, S., Wu, H-L. W., Clarke, M. A., Wheeler, L., and Crooke, S. T. 1987. Inhibition of phosphoinoside-specific phospholipase C by manoalide. Mol Pharmacol. 32:587-593.
29. 2 enzymes on product-containing vesicles: application to the determination of substrate preferences. Biochemistry 32:5949-5958.
30. Bennett, C. F., Mong, S., Clarke, M. A., Kruse, L. I., and Crooke, S. T. 1987. Differential effects of manoalide on secreted and intracellular phospholipases. Biochem. Pharmacol 36:733-740.
31. Bianco, I. D., Kelley, M. J., Crowl, R. M., and Dennis, E. A. 1995. Identification of two specific lysines responsible for the inhibition of phospholipase A2 by manoalide. Biochim. Biophys. Acta 1250:197-203.
32. Yoshida, S., Ikeda, M., Busto, R., Santiso, M., Martinez, E., and Ginsberg, M. D. 1986. Cerebral phosphoinoside, triacylglycerol, and energy metabolism in reversible ischemia: origin and fate of free fatty acids. J. Neurochem. 47:744-757.
33. Waku, K. 1992. Origins and fates of fatty acyl-CoA esters. Biochim. Biophys. Acta 1124:101-111.
34. 14C]palmitate into rat brain: effect of an inhibitor of β-oxidation. J. Lipid Res. 38:295-300.
35. Sun, G. Y., and Su, K. L. 1979. Metabolism of arachidonoyl phosphoglycerides in mouse brain subcellular fractions. J. Neurochem. 32:1053-1959.