The kinetic behaviour of [3H]DOPA in living rat brain investigated by compartmental modelling of static autoradiograms

Journal of Neuroscience Methods

Volumn 78, Issue 1-2, 1997, Pages 157-168

  Deep, Paul ^a   Kuwabara, Hiroto ^b   Gjedde, Albert ^c   Cumming, Paul ^a  

^a MCGILL UNIVERSITY   (Canada)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

3H DOPA autoradiography; 3H Dopamine; Blood brain clearance; Chromatographic fractionation; Compartmental model; DOPA decarboxylase activity; Kinetic constants; Rat brain

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); AROMATIC LEVO AMINO ACID DECARBOXYLASE; DOPA; DOPAMINE; TRITIUM;

ACCURACY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING KINETICS; COMPARTMENT MODEL; DECARBOXYLATION; FRACTIONATION; HEMISPHERE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VALIDATION PROCESS; ANIMAL; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; BLOOD BRAIN BARRIER; BRAIN; CHEMICAL MODEL; KINETICS; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; REGRESSION ANALYSIS; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ANIMALS; AUTORADIOGRAPHY; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; DIHYDROXYPHENYLALANINE; DOPA DECARBOXYLASE; DOPAMINE; KINETICS; MALE; METABOLIC CLEARANCE RATE; MODELS, CHEMICAL; MODELS, NEUROLOGICAL; ORGAN SPECIFICITY; RATS; RATS, WISTAR; REGRESSION ANALYSIS; TRITIUM;

EID: 0031592236     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0270(97)00147-7     Document Type: Article

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