Radiofluorinated L-m-tyrosines: New in-vivo probes for central dopamine biochemistry

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 4, 1996, Pages 667-678

  Barrio, Jorge R ^a   Huang, Sung Cheng ^a   Yu, Dan Chu ^a   Melega, William P ^a   Quintana, Javier ^a   Cherry, Simon R ^a   Jacobson, Andrew ^a   Namavari, Mohammad ^a   Satyamurthy, Nagichettiar ^a   Phelps, Michael E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

4; 6 FMT; 6 18F fluoro L m tryosine; Dopaminergic probes; FMT; L DOPA

Indexed keywords

AMINO ACID DECARBOXYLASE; AROMATIC AMINO ACID; FLUORINE 18; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOPAMINE BRAIN LEVEL; DOPAMINE METABOLISM; DOPAMINERGIC SYSTEM; ENZYME ACTIVITY; MONKEY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RODENT; SIGNAL NOISE RATIO;

EID: 19144373156     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199607000-00018     Document Type: Article

References (29)

1. Awapara J, Sandman RP, Hanly C (1962) Activation of dopa decarboxylase by pyridoxal phosphate. Arch Biochem Biophys 98:520-525
2. Baker H, Abate C, Szabo A, Joh TH (1991) Species specific distribution of aromatic amino acid decarboxylase in the rodent adrenal gland, cerebellum and olfactory bulb. J Comp Neurol 305:119-129
3. Barrio JR (1991) Approaches to the design of biochemical probes for positron emission tomography. Neurochem Res 16:1047-1054
4. 18F]fluoro-L-DOPA probes dopamine turn-over rates in central dopaminergic structures. J Neurosci Res 27:487-493
5. 18F]fluorodopamine and analogs. J Cereb Blood Flow Metab 15:S652 (Abst)
6. 18F]fluoroethyI)spiperone: in-vivo biochemical and kinetic characterization in rodents, non-human primates and humans. J Cereb Blood Flow Metab 9:830-839
7. Borri-Voltattorni C, Minelli A, Dominici P (1983) Interaction of aromatic amino acids in D and L forms with DOPA decarboxylase from pig kidney. Biochemistry 22:2249-2254
8. Boxenbaum H (1982) Interspecies scaling, aelometry, physiological time, and the ground plan of pharmacokinetics. J Pharmacokinet Biopharmacol 10:201-227
9. Calne DB, Langsten JW, Martin WRW, Stoessl AJ, Ruth TJ, Adam MJ, Pate BD, Schulzer M (1985) Positron emission tomography after MPTP: observations relating to the cause of Parkinson's disease. Nature 317:246-248
10. Cardellini M, Cingollani GM, Claudi F, Perlini V, Baldwini W, Cattabeni F (1988) Synthesis and dopamine receptor affinity of 2-(3-fluoro-4-hydroxyphenyl) ethylamine and its Af-alkyl derivatives. Farmaco Ed Sci 43:49-59
11. Carson RE, Huang SC, Phelps ME (1981) BLD: a software system for physiological data handling and model analysis. Proceedings of Fifth Annual Symposium on Computer Applications in Medical Care, Washington, DC, August, pp 562-565
12. Chiueh CC, Burns RS, Kopin IJ, Firnau G, Chirakal R, Nahmias C, Garnett ES (1986) Determination and visualization of damage of striatal dopaminergic terminals in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonian monkeys by fluorine-18 labelled 6-fluoro-L-dopa and positron emission tomography. Adv Neurol 45:167-169
13. Claudi F, Giorgioni G, Distefano A, Abbracchio MP, Paoletti AM, Balduini W (1992) Synthesis and pharmacological characterization of 2-(4-chloro-3-hydroxyphenyl)ethylamine and N,N-dialkyl derivatives as dopamine receptor ligands. J Med Chem 35:4408-4414
14. Cumming P, Boyes BE, Martin WRW (1987) The metabolism of [F-18]-6-fluoro-L-3,4-dihydroxyphenylalanine in the hooded rat. J Neurochem 48:601-608
15. Cutler PD, Cherry SR, Hoffman EJ, Digby WM, Phelps ME (1992) Design features and performance of a PET system for animal research. J Nucl Med 33:595-604
16. Doudet DJ, Miyake H, Finn RT, McLellan CA, Aigner TG, Wan RQ, Adams HR, Cohen RM (1989) 6-[F-18]-L-Dopa imaging of the dopamine neostriatal system in normal and clinically normal MPTP-treated rhesus monkeys. Exp Brain Res 78:69-80
17. Firnau G, Garnett ES, Chirakal R, Sudesh S, Nahmias C, Schrobilgen G (1986) [F-18]Fluoro-L-dopa for the in vivo study of intracerebral dopamine. Int J Appl Radiat Isotopes 37:669-675
18. Firnau G, Sood S, Chirakal R, Nahmias C, Garnett ES (1987) Cerebral metabolism of 6-[F-18]fluoro-L-3,4-dihydroxyphenylalanine in the primate. J Neurochem 48:1077-1082
19. Garnett ES, Firnau G, Nahmias C (1983a) Dopamine visualized in the basal ganglia of living man. Nature 305:137-138
20. Garnett ES, Firnau G, Nahmias C, Chirakal R (1983b) Striatal dopamine metabolism in living monkeys examined with positron emission tomography. Brain Res 280:169-171
21. Gjedde A, Reith J, Dyve S, Leger G, Guttman M, Diksic M (1991) Dopa decarboxylase activity of the living human brain. Proc Natl Acad Sci 88:2721-2725
22. Guttman M, Burns RS, Martin WRW, Peppard RF, Adam MJ, Ruth TJ, Allen G, Parker RA, Tulipan NB, Calne DB (1989) PET studies of parkinsonian patients treated with autologous adrenal implants. Can J Neurol Sci 16:305-309
23. 18F]6-fluoro-L-m-tyrosine in the human brain. Move Disord 10:298-304
24. Nakazato T, Akiyama A (1992) Decarboxylation of exogenous L-3,4-dihydroxyphenylaIanine in rat striatum as studied by in-vivo voltametry. J Neurochem 58:121-127
25. 18F]fluoro-L-dopa. Appl Radiat Isot 43:989-996
26. 18F]fluoro-L-m-tyrosines via regioselective radiofluorodestannylation. Appl Radiat Isot 44:527
27. Pate B, Kawamata T, Yamada T, McGeer EG, Hewitt KA, Snow BJ, Ruth TJ, Calne DB (1993) Correlation of striatal fluorodopa uptake in the MPTP monkey with dopaminergic indices. Ann Neurol 34:331-338
28. Patlak CS, Blasberg RG, Feustenmacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1-7
29. Rahman MK, Nagatsu T, Kato T (1981a) Aromatic L-amino acid decarboxylase activity in central and peripheral tissues and serum of rats with DOPA and 5HTP as substrates. Biochem Pharmacol 30:645-649