Phorbol ester-mediated induction of cyclooxygenase-2 gene expression is inhibited by retinoids

Annals of the New York Academy of Sciences

Volumn 833, Issue , 1997, Pages 173-178

  Mestre, Juan R ^a,b   Subbaramaiah, Kotha ^a   Sacks, Peter G ^b   Schantz, Stimson P ^b   Dannenberg, Andrew J ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; PHORBOL ESTER; RETINOID;

CONFERENCE PAPER; GENE EXPRESSION; GENE INDUCTION; GENE REPRESSION;

EID: 0031590801     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48605.x     Document Type: Conference Paper

References (23)

1. ELING, T. E. et al. 1990. Prostaglandin H synthase and xenobiotic oxidation. Annu. Rev. Pharmacol. Toxicol. 30: 1-45.
2. TSUJII, M. & R. N. DUBOIS. 1995. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83: 493-501.
3. BOOLBOL, S. K. et al. 1996. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res. 56: 2556-2560.
4. MCCORMICK, D. L. & R. C. MOON. 1983. Inhibition of mammary carcinogenesis by flurbiprofen, a non-steroidal antiinflammatory agent. Br. J. Cancer 48: 859-861.
5. GIARDIELLO, F. M. et al. 1993. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N. Engl. J. Med. 328: 1313-1316.
6. KUJUBU, D. A. et al. 1991. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J. Biol. Chem. 266: 12866-12872.
7. DUBOIS, R. N. et al. 1994. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-α and phorbol ester. J. Clin. Invest. 93: 493-498.
8. RIMARACHIN, J. A. et al. 1994. Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells. Arterioscl. Thromb. 14: 1021-1031.
9. MOON, R. C., D. L. MCCORMICK & R. G. MEHTA. 1983. Inhibition of carcinogenesis by retinoids. Cancer Res. 43: 2469s-2475s.
10. HONG, W. K. et al. 1986. 13-cis-retinoic acid in the treatment of oral leukoplakia. N. Engl. J. Med. 315: 1501-1505.
11. SCHULE, R. et al. 1991. Retinoic acid is a negative regulator of AP-1-responsive genes. Proc. Natl. Acad. Sci. USA 88: 6092-6096.
12. XIE, W. & H. R. HERSCHMAN. 1995. v-src induced prostaglandin synthase 2 gene expression by activation of c-Jun N-terminal kinase and the c-Jun transcription factor. J. Biol. Chem. 270: 27622-27628.
13. SACKS, P. G. et al. 1988. Establishment and characterization of two new squamous cell carcinoma cell lines derived from tumors of the head and neck. Cancer Res. 48: 2858-2866.
14. MESTRE, J. R. et al. 1997. Retinoids suppress phorbol ester-mediated induction of cyclooxygenase-2. Cancer Res. 57: 1081-1085.
15. HABIB, A. et al. 1993. Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of cyclooxygenase-2. J. Biol. Chem. 268: 23448-23454.
16. SUBBARAMAIAH, K. et al. 1996. Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells. Cancer Res. 56: 4421-1129.
17. KUTCHERA, W. et al. 1996. Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: Evidence for a transcriptional effect. Proc. Natl. Acad. Sci. USA 93: 4816-4820.
18. SANO, H. et al. 1995. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. 55: 3785-3789.
19. KARGMAN, S. L. et al. 1995. Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res. 55: 2556-2559.
20. LU, X. et al. 1995. Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenase in chicken embryo fibroblasts. Proc. Natl. Acad. Sci. USA 92: 7961-7965.
21. WEITZMAN, S. A. & L. I. GORDON. 1990. Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood 76: 655-663.
22. ZOU, C-P. et al. 1994. Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines. Cancer Res. 54: 5479-5487.
23. INOUE, H. et al. 1995. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. J. Biol. Chem. 270: 24965-24971.