Asymmetric conjugate addition of diethyl zinc to enones with chiral phosphine ligands

Tetrahedron Asymmetry

Volumn 8, Issue 24, 1997, Pages 3987-3990

  Alexakis, A ^a   Burton, J ^a   Vastra, J ^a   Mangeney, P ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOHEXENONE; BENZYLIDENEACETONE; CHALCONE; KETONE;

ARTICLE; CATALYSIS; CHIRALITY; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; METHODOLOGY; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0031584583     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00523-5     Document Type: Article

References (26)

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26. 2Zn (1 M sol. in hexanes, 7 mL, 7 mmol) was added followed by a solution of the enone (5 mmol) in dichloromethane (3 mL). The reaction was followed by GC until completion. Acidic work-up and chromatography gave the pure adduct.