KB-R7785, A novel matrix metalloproteinase inhibitor, exerts ,its antidiabetic effect by inhibiting tumor necrosis factor-α production

Life Sciences

Volumn 61, Issue 8, 1997, Pages 795-803

  Morimoto, Yasuo ^a   Nishikawa, Kaori ^a   Ohashi, Masami ^a  

^a KANEBO LTD   (Japan)

Author keywords

Diabetes; Matrix metalloproteinease inhibitor; Tumor necrosis factor

Indexed keywords

[4 (N HYDROXYAMINO) 2 ISOBUTYL 3 METHYLSUCCINYL] PHENYLGLYCINE N METHYLAMIDE; ANTIDIABETIC AGENT; KB R 7785; MATRIX METALLOPROTEINASE INHIBITOR; PIOGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL DRUG ADMINISTRATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; GLYCINE; HYDROXAMIC ACIDS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; METALLOENDOPEPTIDASES; MICE; MICE, INBRED BALB C; PROTEASE INHIBITORS; THIAZOLES; THIAZOLIDINEDIONES; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0031577286     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(97)00561-4     Document Type: Article

References (27)

1. 1. T. VAN DER POLL, J.A. ROMIJN, E. ENDERT, J.J.J. BORM, H.R. BÜLLER and H.P. SAUERWEIN, Am. J. Physiol. 261 (Endocrinol. Metab. 24) E457-E465 (1991).
2. 2. C.H. LANG, C. DOBRESCU and G.J. BAGBY, Endocrinology 130 43-52 (1992).
3. 3. J.L. McCALL, J.A. TUCKEY and B.R. PARRY, Br. J. Surg. 79 1361-1363 (1992).
4. 4. G.S. HOTAMISLIGIL, N.S. SHARGILL and B.M. SPIEGELMAN, Science 259 87-91 (1993).
5. 5. C. HOFMANN, K. LORENZ, S.S. BRAITHWAITE, J.R. COLCA, B.J. PALAZUK, G.S. HOTAMISLIGIL and B.M. SPIEGELMAN, Endocrinology 134 264-270 (1994).
6. 6. G.S. HOTAMISLIGIL, P. ARNER, J.F. CARO, R.L. ATKINSON and B.M. SPIEGELMAN, J. Clin. Invest. 95 2409-2415 (1995).
7. 7. M. SAGHIZADEH, J.M. ONG, W.T. GARVEY, R.R. HENRY and P.A. KERN, J. Clin. Invest. 97 1111-1116 (1996).
8. 8. R. FEINSTEIN, H. KANETY, M.Z. PAPA, B. LUNENFELD and A. KARASIK, J. Biol. Chem. 268 26055-26058 (1993).
9. 9. G.S. HOTAMISLIGIL, D.L. MURRAY, L.N. CHOY and B.M. SPIEGELMAN, Proc. Natl. Acad. Sci. USA 91 4854-4858 (1994).
10. 10. G.S. HOTAMISLIGIL, A. BUDABARI, D.L. MURRAY and B.M. SPIEGELMAN, J. Clin. Invest. 94 1543-1549 (1994).
11. 11. A.J.H. GEARING, P. BECKETT, M. CHRISTODOULOU, M. CHURCHILL, J. CLEMENTS, A.H. DAVIDSON, A.H. DRUMMOND, W.A. GALLOWAY, R. GILBERT, J.L. GORDON, T.M. LEBER, M. MANGAN, K. MILLER, P. NAYEE, K. OWEN, S. PATEL, W. THOMAS, G. WELLS, L.M. WOOD and K. WOOLLEY, Nature 370 555-557 (1994).
12. 12. G.M. McGEEHAN, J.D. BECHERER, R.C. BAST Jr, C.M. BOYER, B. CHAMPION, K.M. CONNOLLY, J.G. CONWAY, P. FURDON, S. KARP, S. KIDAO, A.B. McELROY, J. NICHOLS, K.M. PRYZWANSKY, F. SCHOENEN, L. SEKUT, A. TRUESDALE, M. VERGHESE, J. WARNER and J.P. WAYS, Nature 370 558-561 (1994).
13. 13. K.M. MOHLER, P.R. SLEATH, J.N. FITZNER, D.P. CERRETTI, M. ALDERSON, S.S. KERWAR, D.S. TORRANCE, C. OTTEN-EVANS, T. GREENSTREET, K. WEERAWARNA, S.R. KRONHEIM, M. PETERSEN, M. GERHART, C.J. KOZLOSKY, C.J. MARCH and R.A. BLACK, Nature 370 218-220 (1994).
14. 14. T. YAMAKAWA, S. TANAKA, Y. YAMAKAWA, Y. KIUCHI, F. ISODA, S. KAWAMOTO, K. OKUDA and H. SEKIHARA, Clin. Immunol. Immunopathol. 75 51-56 (1995).
15. 15. G.S. HOTAMISLIGIL and B.M. SPIEGELMAN, Diabetes 43 1271-1278 (1994).
16. 16. Y. OHNO, N. AOKI and A. NISHIMURA, J. Clin. Endocrinol. Metab. 77 1072-1077 (1993)
17. 17. C. HOFMANN, K. LORENZ and J.R. COLCA, Endocrinology 129 1915-1925 (1991).
18. 18. I.M. EL-KEBBI, S. ROSER and R.J. POLLET, Metabolism 43 953-958 (1994).
19. 19. M. KOBAYASHI, M. IWANISHI, K. EGAWA and Y. SHIGETA, Diabetes 41 476-483 (1992).
20. 20. M. IWANISHI and M. KOBAYASHI, Metabolism 42 1017-1021 (1993).
21. 21. H. MAEGAWA, R. TACHIKAWA-IDE, S. UGI, M. IWANISHI, K. EGAWA, R. KIKKAWA, Y. SHIGETA and A. KASHIWAGI, Biochem. Biophys. Res. Commun. 197 1078-1082 (1993).
22. 22. H. IKEDA, S. TAKETOMI, Y. SUGIYAMA, Y. SHIMURA, T. SOHDA, K. MEGURO and T. FUJITA, Arzneimittelforschung 40 156-162 (1990).
23. 23. J.M. LEHMANN, L.B. MOORE, T.A. SMITH-OLIVER, W.O. WILKISON, T.M. WILLSON and S.A. KLIEWER, J. Biol. Chem. 270 12953-12956 (1995).
24. 24. B.M. FORMAN, P. TONTONOZ, J. CHEN, R.P. BRUN, B.M. SPIEGELMAN and R.M. EVANS, Cell 83 803-812 (1995).
25. 25. D. SZALKOWSKI, S. WHITE-CARRINGTON, J. BERGER and B. ZHANG, Endocrinology 136 1474-1481 (1995).
26. 26. H. VLASSARA, M. BROWNLEE, K.R. MANOGUE, C.A. DINARELLO and A. PASAGIAN, Science 240 1546-1548 (1988).
27. 27. G. HASEGAWA, K. NAKANO, M. SAWADA, K. UNO, Y. SHIBAYAMA, K. IENAGA and M. KONDO, Kidney Int. 40 1007-1012 (1991).