Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7β,8α-dihydroxy-9α,10α-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

Biochemical and Biophysical Research Communications

Volumn 235, Issue 2, 1997, Pages 424-428

  Hu, Xun ^a   O'Donnell, Rosemary ^b   Srivastava, Sanjay K ^a   Xia, Hong ^a   Zimniak, Piotr ^c   Nanduri, Bindu ^c   Bleicher, Richard J ^a   Awasthi, Sanjay ^d   Awasthi, Yogesh C ^d   Ji, Xinhua ^b   Singh, Shivendra V ^a  

^a MERCY HOSPITAL OF PITTSBURGH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; CARCINOGEN; GLUTATHIONE; GLUTATHIONE TRANSFERASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; GLUTATHIONE METABOLISM; HUMAN; MICHAELIS MENTEN KINETICS; MOLECULAR MODEL; PRIORITY JOURNAL;

OXY;

EID: 0031577161     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1997.6777     Document Type: Article

References (23)

1. 1. Denissenko, M. F., Pao, A., Tang, M.-S., and Pfeifer, G. P. (1996) Science 274, 430-432.
2. 2. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. (1991) p53 mutations in human cancers. Science 253, 49-53. [Review]
3. 3. Levine, A. J., Wu, M. C., Chang, A., Silver, A., Attiyeh, E. F., Lin, J., and Epstein, C. B. (1995) Anal. New York Acad. Sci. 768, 111-128.
4. 4. Thakker, D. R., Yagi, H., Levin, W., Wood, A. W., Conney, A. H., and Jerina, D. M. (1985) in Bioactivation of Foreign Compounds, (Anders, M. W., Ed.), pp. 177-242, Academic Press, New York.
5. 5. Wood, A. W., Chang, R. L., Levin, W., Yagi, H., Thakker, D. R., Jerina, D. M., and Conney, A. H. (1977) Biochem. Biophys. Res. Commun. 77, 1389-1396.
6. 6. Buening, M. K., Wislocki, P. G., Levin, W., Yagi, H., Thakker, D. R., Akagi, H., Koreeda, M., Jerina, D. M., and Conney, A. H. (1978) Proc. Natl. Acad. Sci. USA 75, 5358-5361.
7. 7. Slaga, T. J., Bracken, W. J., Gleason, G., Levin, W., Yagi, H., Jerina, D. M., and Conney, A. H. (1979) Cancer Res. 39, 67-71.
8. 8. Thakker, D. R., Yagi, H., Levin, W., Lu, A. Y. H., Conney, A. H., and Jerina, D. M. (1977) J. Biol. Chem. 252, 6328-6334.
9. 9. Robertson, I. G. C., Guthenberg, C., Mannervik, B., and Jernström, B. (1986) Cancer Res. 46, 2220-2224.
10. 10. Hu, X., Srivastava, S. K., Xia, H., Awasthi, Y. C., and Singh, S. V. (1996) J. Biol. Chem. 271, 32684-32688.
11. 11. Hayes, J. D., and Pulford, D. J. (1995) Crit. Rev. Biochem. Mol. Biol. 30, 445-600.
12. 12. Mannervik, B., Alin, P., Guthenberg, C., Jensson, H., Tahir, M. K., Warholm, M., and Jornvall, H. (1985) Proc. Natl. Acad. Sci. USA 82, 7202-7206.
13. 13. Mannervik, B., Awasthi, Y. C., Board, P. G., Hayes, J. D., Dillio, C., Ketterer, B., Listowsky, I., Morgenstern, R., Muramatsu, M., Pearson, W. R., Pickett, C. B., Sato, K., Widersten, M., and Wolf, C. R. (1992) Biochem. J. 282, 305-308.
14. 14. Ahmad, H., Wilson, D. E., Fritz, R. R., Singh, S. V., Medh, R. D., Nagle, G. T., Awasthi, Y. C., and Kurosky, A. (1990) Arch. Biochem. Biophys. 278, 398-408.
15. 15. Board, P. G., Webb, G. C., and Coggan, M. (1989) Ann. Hum. Genet. 53, 205-213.
16. 16. Lo, H.-W., Antoun, G., and Ali-Osman, F. (1996) Proc. International Conference on Glutathione and Glutathione-linked Enzymes in Human Cancer and Other Diseases, Hilton Head, South Carolina, Oct. 31-Nov. 3, pp. OP-21.
17. 17. Board, P. G., Harris, M., Flanagan, J., and Coggan, M. (1996) Proc. International Conference on Glutathione and Glutathione-linked Enzymes in Human Cancer and Other Diseases, Hilton Head, South Carolina, Oct. 31-Nov. 3, pp. OP-16.
18. 18. Wolf, C. R., Henderson, C., Smith, A., Bishop, J. O., Moffat, G., and Harries, L. W. (1996) Proc. International Conference on Glutathione and Glutathione-linked Enzymes in Human Cancer and Other Diseases, Hilton Head, South Carolina, Oct. 31-Nov. 3, pp. OP-8.
19. 19. Zimniak, P., Nanduri, B., Pikula, S., Bandorowicz-Pikula, J., Singhal, S. S., Srivastava, S. K., Awasthi, S., and Awasthi, Y. C. (1994) Eur. J. Biochem. 224, 893-899.
20. 20. Ji, X., O'Donnell, R., Gilliland, G. L., Tordova, M., Armstrong, R. N., Parsons, J. F., Zimniak, P., and Hayden, J. B. (1996) Proc. International Conference on Glutathione and Glutathione-linked Enzymes in Human Cancer and Other Diseases, Hilton Head, South Carolina, Oct. 31-Nov. 3, pp. PP-6.
21. 21. Ji, X., Johnson, W. W., Sesay, M. A., Dickert, L., Prassad, S. M., Ammon, H. L., Armstrong, R. N., and Gilliland, G. L. (1994) Biochemistry 33, 1043-1052.
22. 22. Powell, M. J. D. (1977) Math. Prog. 12, 241-254.
23. 23. Engh, R. A., and Huber, R. (1991) Acta Crystallogr. A47, 392-400.