A highly efficient aminohydroxylation process

Angewandte Chemie (International Edition in English)

Volumn 36, Issue 23, 1997, Pages 2637-2640

  Rubin, A Erik ^a   Sharpless, K Barry ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Amino alcohols; Aziridines; Chloramine T; Homogeneous catalysis; Osmium

Indexed keywords

EID: 0031573889     PISSN: 05700833     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.199726371     Document Type: Article

References (37)

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26. 2O (1/1) [4a-d]. Acetamide-based AA uses the same standard conditions but with 1.1 equiv of AcNLiBr in place of the chloramine salt [4e].
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37. Another advantage of racemates, pointed out by a reviewer, is that modern preparative chiral HPLC often enables access to both enantiomers. The pharmaceutical industry now favors this approach for quick "enantiodeconvolutiuon" of biological activity.