Early region 4 modulates adenovirus DNA replication by two genetically separable mechanisms

Virology

Volumn 236, Issue 1, 1997, Pages 8-17

  Medghalchi, Susan ^a,c   Padmanabhan, R ^b   Ketner, Gary ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR AP 1; VIRUS PROTEIN;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; GENE EXPRESSION; IMMUNOPRECIPITATION; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALIA;

EID: 0031572229     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8737     Document Type: Article

References (45)

1. Berkner, K. L., and Sharp, P. A. (1983). Generation of adenovirus by transfection of plasmids. Nucleic Acids Res. 11, 6003-6020.
2. Bondesson, M., Öhman, K., Mannervik, M., Fan, S., and Akusjärvi, G. (1996). Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter. J. Virol. 70, 3844-3851.
3. Bridge, E., and Ketner, G. (1989). Redundant control of adenovirus late gene expression by early region 4. J. Virol. 63, 631-638.
4. Bridge, E., and Ketner, G. (1990). Interaction of adenoviral E4 and E1b products in late gene expression. Virology 174, 345-353.
5. Bridge, E., Medghalchi, S., Ubol, S., Leesong, M., and Ketner, G. (1993). Adenovirus early region 4 and viral DNA synthesis. Virology 193, 794-801.
6. Carvalho, T., Seeler, J. S., Öhman, K., Jordan, P., Pettersson, U., Akusjarvi, G., Carmo-Fonseca, M., and Dejean, A. (1995). Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies. J. Cell Biol. 131, 45-56.
7. Challberg, M. D., and Kelly, T. J., Jr. (1989). Animal virus DNA replication. Annu. Rev. Biochem. 58, 671-717.
8. Dobner, T., Horikoshi, N., Rubenwolf, S., and Shenk, T. (1996). Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science 272, 1470-1473.
9. Fryer, G. A., Katoh, Y., and Roberts, R. J. (1984). Characterization of the major mRNAs from adenovirus 2 early region 4 by cDNA cloning and sequencing. Nucleic Acids Res. 12, 3503-3519.
10. Gaynor, R. B., Tsukamoto, A., Montell, C., and Berk, A. J. (1982). Enhanced expression of adenovirus transforming proteins. J. Virol. 44, 276-285.
11. Graham, F. L., and van der Eb, A. J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
12. Grenfell, S. J., Latchman, D. S., and Thomas, N. S. (1996). CT-1 and Oct-2 DNA binding site specificity is regulated in vitro by different kinases. Biochem. J. 315, 889-893.
13. Halbert, D. N., Cutt, J. R., and Shenk, T. (1985). Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. J. Virol. 56, 250-257.
14. Hay, R. T., Freeman, A., Leith, I., Monaghan, A., and Webster, A. (1995). Molecular interactions during adenovirus DNA replication. Curr. Top. Microbiol. Immunol. 199(II), 31-48.
15. Hérissé, J., Rigolet, M., Du Pont de Dinechin, S., and Galibert, F. (1981). Nucleotide sequence of adenovirus 2 DNA fragment encoding the carboxylic region of the fiber protein and the entire E4 region. Nucleic Acids Res. 9, 4023-4042.
16. Huang, M., and Hearing, P. (1989a). Adenovirus early region 4 encodes two products with redundant activities in lytic infection. J. Virol. 63, 2605-2615.
17. Huang, M., and Hearing, P. (1989b). The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of cellular transcription factor E2F through a direct complex. Genes Dev. 3, 1699-1710.
18. Ketner, G., Bridge, E., Virtanen, A., Hemström, C., and Pettersson, U. (1989). Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids. Nucleic Acids Res. 17, 3037-3048.
19. Kusukawa, J., Ramachandra, M., Nakano, R., and Padmanabhan, R. (1994). Phosphorylation-dependent interaction of adenovirus preterminal protein with the viral origin of DNA replication. J. Virol. 69, 2189-2196.
20. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227, 680-685.
21. Leavitt, J., Gunning, P., Porreca, P., Ng, S. Y., Lin, C. S., and Kedes, L. (1984). Molecular cloning and characterization of mutant and wild-type human β-actin genes. Mol. Cell. Biol. 4, 1961-1969.
22. Müller, U., Roberts, M. P., and Shenk, T. (1990). Adenovirus E1A protein and cAMP act in concert to activate transcription of AP-1 and ATF/ CFEB binding site containing promoters. In "Structure and Function of Nucleic Acids and Proteins" (F. Y.-H. Wu and C.-W. Wu, Ed.), pp. 249-258. Raven Press, New York.
23. Müller, U., Kleinberger, T., and Shenk, T. (1992). Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1a proteins while simultaneously reducing the level of AP-1. J. Virol. 66, 5867-5878.
24. Neill, S. D., Hemström, C., Virtannen, A., and Nevins, J. R. (1990). An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. Proc. Natl. Acad. Sci. USA 87, 2008-2012.
25. Neill, S. D., and Nevins, J. R. (1991). Genetic analysis of the E4 6/7 trans-activator: Interaction with E2F and the induction of a stable DNA-protein complex are critical for activity. J. Virol. 65, 5364-5373.
26. Nordqvist, K., Öhman, K., and Akusjärvi, G. (1994). Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs. Mol. Cell. Biol. 14, 437-445.
27. Öhman, K., Nordqvist, K., and Akusjärvi, G. (1993). Two adenovirus proteins with redundant activities in virus growth facilitate tripartite leader mRNA accumulation. Virology 194, 50-58.
28. Ornelles, D. A., and Shenk, T. (1991). Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: Association with nuclear viral inclusions requires the early region 4 34-kilodalton protein. J. Virol. 65, 424-439.
29. Ramachandra, M., Nakano, R., Mohan, P. M., Rawitch, A. B., and Padmanabhan, R. (1993). Adenovirus DNA polymerase is a phosphoprotein. J. Biol. Chem. 268, 442-448.
30. Ramachandra, M., and Padmanabhan, R. (1993). Adenovirus DNA polymerase is phosphorylated by a stably associated histone H1 kinase. J. Biol. Chem. 268, 17448-17456.
31. Ramachandra, M., and Padmanabhan, R. (1995). Expression, nuclear transport, and phosphorylation of adenovirus DNA replication proteins. Curr. Topics Microbiol. Immunol. 199(II), 49-88.
32. Raychaudhuri, P., Bagchi, S. D., Neill, S., and Nevins, J. R. (1990). Activation of the E2F transcription factor in adenovirus-infected cells involves the E1A-dependent stimulation of DNA binding activity and induction of cooperative binding mediated by an E4 gene product. J. Virol. 64, 2702-2710.
33. Reich, N. C., Sarnow, P., Duprey, E., and Levine, A. J. (1983). Monoclonal antibodies which recognize native and denatured forms of the adenovirus DNA-binding protein. Virology 128, 480-484.
34. Robinson, A. J., and Bellett, A. J. D. (1974). A circular DNA-protein complex for adenoviruses and its possible role in DNA replication. Cold Spring Harbor Symp. Quant. Biol. 39, 523-531.
35. Sambrook, J., Fritsch, E. R., and Maniatis, T. (1989). "Molecular Cloning: A Laboratory Manual," 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
36. Sandler, A. B., and Ketner, G. (1991). The metabolism of host mRNAs in cells infected by an adenovirus E4 mutant. Virology 181, 319-326.
37. Sasaguri, Y., Sanford, T., Aguire, P., and Padmanabhan, R. (1987). Immunological analysis of 140-kDa adenovirus-encoded DNA polymerase in adenovirus type 2-infected cells using antibodies raised against the protein expressed in Escherichia coll. Virology 160, 389-399.
38. Sassone-Corsi, P., Ransone, L. J., Lamph, W. W., and Verma, I. M. (1990). Cross-talk in signal transduction: TPA inducible factor jun/AP-1 activates a cAMP responsive enhancer element. Oncogene 5, 427-431.
39. Segil, N., Roberts, S. B., and Heintz, N. (1991). Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. Science 254, 1814-1816.
40. Swaminathan, S., and Thimmapaya, B. (1996). Transactivation of the E2 early promoter by E1A and E4 6/7 in the context of the viral chromosome. J. Mol. Biol. 258, 736-746.
41. van der Vliet, P. C. (1995). Adenovirus DNA replication. Curr. Top. Microbiol. Immunol. 199(II), 1-30.
42. Virtanen, A., Gilardi, P., Naslünd, A., Le Moullec, J. M., Pettersson, U., and Perricaudet, M. (1984). mRNAs from human adenovirus 2 early region 4. J. Virol. 51, 822-831.
43. Weiden, M. D., and Ginsberg, H. S. (1994). Deletion of the E4 region of the genome produces adenovirus DNA concatemers. Proc. Natl. Acad. Sci. USA 91, 153-157.
44. Weinberg, D. H., and Ketner, G. (1983). A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2. Proc. Natl. Acad. Sci. USA 80, 5383-5386.
45. Zhao, L., and Padmanabhan, R. (1988). Nuclear transport of adenovirus DNA polymerase is facilitated by interaction with preterminal protein. Cell 55, 1005-1015.