Increased expression of signaling lymphocytic activation molecule in patients with rheumatoid arthritis and its role in the regulation of cytokine production in rheumatoid synovium

Journal of Immunology

Volumn 159, Issue 6, 1997, Pages 2986-2993

  Isomäki, Pia ^a   Aversa, Gregorio ^b   Cocks, Benjamin G ^b   Luukkainen, Reijo ^c   Saario, Riitta ^a   Toivanen, Paavo ^a   De Vries, Jan E ^b   Punnonen, Juha ^a,b  

^a Turku University   (Finland)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Satalinnan Sairaala   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CD150 ANTIGEN; CELL SURFACE RECEPTOR; CYTOKINE; GLYCOPROTEIN; IMMUNOGLOBULIN; LEUKOCYTE ANTIGEN;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; FLOW CYTOMETRY; HUMAN; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MIDDLE AGED; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIUM;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ARTHRITIS, RHEUMATOID; CYTOKINES; FLOW CYTOMETRY; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULINS; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MIDDLE AGED; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE;

EID: 0031571811     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.159.6.2986     Document Type: Article

References (11)

1. Maini, R. N., C. Q. Chu, and M. Feldmann. 1995. Aetiopathogenesis of rheumatoid arthritis. In Mechanisms and Models in Rheumatoid Arthritis. B. Henderson, J. C. W. Edwards, and E. R. Pettipher, eds. Academic Press, London, p. 25.
2. Panayi, G. S., J. S. Lanchbury, and G. H. Kingsley. 1992. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum. 35:729.
3. Duke, O., G. S. Panayi, G. Janossy, and L. W. Poulter. 1982. An immunohistological analysis of lymphocyte subpopulations and their microenvironment in the synovial membranes of patients with rheumatoid arthritis using monoclonal antibodies. Clin. Exp. Immunol. 49:22.
4. Cush, J. J., and P. E. Lipsky. 1988. Phenotypical analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum. 31:1230.
5. Hemler, M. E., D. Glass, J. S. Coblyn, and J. G. Jacobson. 1986. Very late activation antigens on rheumatoid synovial fluid T lymphocytes. J. Clin. Invest. 78:696.
6. Thomas, R., M. McIlraith, L. S. Davis, and P. E. Lipsky. 1992. Rheumatoid synovium is enriched in CD45RBdim mature memory T cells that are potent helpers for B cell differentiation. Arthritis Rheum. 35:1455.
7. Mima, T., Y. Saeki, S. Ohshima, N. Nishimoto, M. Matsushita, M. Shimizu, Y. Kobayashi, T. Nomura, and T. Kishimoto. 1995. Transfer of rheumatoid arthritis into severe combined immunodeficient mice. J. Clin. Invest. 96:1746.
8. Miyasaka, N., K. Sato, M. Goto, M. Sasano, M. Natsuyama, K. Inoue, and K. Nishioka. 1988. Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Arthritis Rheum. 31:480.
9. Hirano, T., T. Matsuda, M. Turner, N. Miyasaka, G. Buchan, B. Tang, K. Sato, M. Shimizu, R. Maini, M. Feldmann, and T. Kishimoto. 1988. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18:1797.
10. Katsikis, P. D., C.-Q. Chu, F. M. Brennan, R. N. Maini, and M. Feldmann. 1994. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J. Exp. Med. 179:1517.
11. Isomäki, P., R. Luukkainen, R. Saario, P. Toivanen, and J. Punnonen. 1996. Interleukin-10 functions as an anti-inflammatory cytokine in rheumatoid synovium. Arthritis Rheum. 39:386.