Heterogeneity in rates of recombination in the 6-Mb region telomeric to the human major histocompatibility complex

Genomics

Volumn 43, Issue 2, 1997, Pages 226-231

  Malfroy, L ^a   Roth, M P ^a   Carrington, M ^b   Borot, N ^a   Volz, A ^c   Ziegler, A ^c   Coppin, H ^a  

^a CHU PURPAN   (France)

^b SAIC FREDERICK INC   (United States)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC HETEROGENEITY; GENETIC RECOMBINATION; HUMAN; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL;

EID: 0031571122     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.4800     Document Type: Article

References (21)

1. 1. Bodmer, J. G., Parham, P., Albert, E. D., and Marsh, S. G. E. (1997). Putting a hold on 'HLA-H'. Nature Genet. 15: 234-235.
2. 2. Burt, M. J., Smit, D. J., Pyper, W. R., Powell, L. W., and Jazwinska, E. C. (1996). A 4.5-megabase YAC contig and physical map over the hemochromatosis gene region. Genomics 33: 153-158.
3. 3. Chakravarti, A., Elbein, S. C., and Permutt, M. A. (1986). Evidence for increased recombination near the human insulin gene: Implication for disease association studies. Proc. Natl. Acad. Sci. USA 83: 1045-1049.
4. 4. Cullen, M., Erlich, H., Klitz, W., and Carrington, M. (1995). Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus. Am. J. Hum. Genet. 56: 1350-1358.
5. 5. El Kahloun, A., Vernet, C., Jouanolle, A. M., Boretto, J., Mauvieux, V., Le Gall, J. Y., David, V., and Pontarotti, P. (1992). A continuous restriction map from HLA-E to HLA-F. Structural comparison between different HLA-A haplotypes. Immunogenetics 35: 183-189.
6. 6. Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., Hinton, L. M., Jones, N. L., Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D. B., Mapa, F. A., McClelland, E., Meyer, N. C., Mintier, G. A., Moeller, N., Moore, T., Morikang, E., Prass, C. E., Quintana, L., Starnes, S. M., Schatzman, R. C., Brunke, K. J., Drayna, D. T., Risch, N. J., Bacon, B. R., and Wolff, R. K. (1996). A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet. 13: 399-408.
7. 7. Jazwinska, E. C., Pyper, W. R., Burt, M. J., Francis, J. L., Goldwurm, S., Webb, S. I., Lee, S. C., Halliday, J. W., and Powell, L. W. (1995). Haplotype analysis in Australian hemochromatosis patients: Evidence for a predominant ancestral haplotype exclusively associated with haemochromatosis. Am. J. Hum. Genet. 56: 428-433.
8. 8. Jorde, L. B., Watkins, W. S., Viskochil, D., O'Connell, P., and Ward, K. (1993). Linkage disequilibrium in the neurofibromatosis I (NF I) region: Implications for gene mapping. Am. J. Hum. Genet. 53: 1038-1050.
9. 9. Martin, M., Mann, D., and Carrington, M. (1995). Recombination rates across the HLA complex: Use of microsatellites as a rapid screen for recombinant chromosomes. Hum. Mol. Genet. 4: 423-428.
10. 10. Moretta, L., Mingari, M. C., Pende, D., Bottino, C., Biassoni, R., and Moretta, A. (1996). The molecular basis of natural killer (NK) cell recognition and function. J. Clin. Immunol. 16: 243-253.
11. 11. Pazmany, L., Mandelboim, O., Vales-Gomez, M., Davis, D. M., Reyburn, H. T., and Strominger, J. L. (1996). Protection from natural killer cell-mediated lysis by HLA-G expression on target cells. Science 274: 792-795.
12. 12. Raha-Chowdhury, R., Bowen, D. J., Stone, C., Pointon, J. J., Terwilliger, J. D., Shearman, J. D., Robson, K. J. H., Bomford, A., and Worwood, M. (1995). New polymorphic microsatellite markers place the haemochromatosis gene telomeric to D6S105. Hum. Mol. Genet. 4: 1869-1874.
13. 13. Seese, N. K., Venditti, C. P., Chorney, K. A., Gerhard, G. S., Ma, J., Hudson, T. J., Phatak, P. D., and Chorney, M. J. (1996). Localization of the hemochromatosis disease gene: Linkage disequilibrium analysis using an American patient collection. Blood Cells Mol. Dis. 22: 36-46.
14. 14. Simon, M., Bourel, M., Fauchet, R., and Genetet, B. (1976). Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis. Gut 17: 332-334.
15. 15. Terwilliger, J. D. (1995). A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am. J. Hum. Genet. 56: 777-787.
16. 16. Thomsen, M., Neugebauer, M., Arnaud, J., Borot, N., Sevin, A., Baur, M., and Cambon-Thomsen, A. (1994). Recombination fractions in the HLA system based on the data set 'Provinces Françaises': Indications of haplotype-specific recombination rates. Eur. J. Immunogenet. 21: 33-43.
17. 17. Tokunaga, K., Saueracker, G., Kay, P. H., Christiansen, F. T., Anand, R., and Dawkins, R. L. (1988). Extensive deletions and insertions in different MHC supratypes detected by pulse field gel eletrophoresis. J. Exp. Med. 168: 933-940.
18. 18. Venditti, C. P., and Chorney, M. J. (1992). Class I gene contraction within the HLA-A subregion of the human MHC. Genomics 14: 1003-1009.
19. 19. Weiss, G., Wachter, H., and Fuchs, D. (1995). Linkage of cell-mediated immunity to iron metabolism. Immunol. Today 16: 495-500.
20. 20. Yoshino, M., Sagai, T., Fisher Lindahl, K., Toyoda, Y., Moriwaki, K., and Shiroishi, T. (1995). Allele-dependent recombination frequency: Homology requirement in meiotic recombination at the hot spot in the mouse major histocompatibility complex. Genomics 27: 298-305.
21. 21. Zhang, W. J., Degli-Esposi, M. A., Cobain, T. J., Cameron, P. U., Christiansen, F. T., and Dawkins, R. L. (1990). Differences in gene copy number carried by different MHC ancestral haplotypes. J. Exp. Med. 171: 2101-2114.