IgH Gene Rearrangements on the Unexpressed Allele in Rabbit B Cells

Journal of Immunology

Volumn 158, Issue 10, 1997, Pages 4805-4811

  Tunyaplin, Chainarong ^a,b   Knight, Katherine L ^a,c  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b College of Physicians and Surgeons ^*  (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL; ARTICLE; B LYMPHOCYTE; GENE EXPRESSION; GENE REARRANGEMENT; GENETICS; HUMAN; HYBRIDOMA; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; RABBIT; RESTRICTION MAPPING;

ALLELES; ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; GENE EXPRESSION; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; HUMANS; HYBRIDOMAS; MICE; MOLECULAR SEQUENCE DATA; RABBITS; RESTRICTION MAPPING;

EID: 0031570030     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302:575.
2. H. Cell 19:981.
3. Alt, F. W., G. D. Yancopoulos, T. K. Blackwell, C. Wood, E. Thomas, M. Boss, R. Coffman, N. Rosenberg, S. Tonegawa, and D. Baltimore. 1984. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 3:1209.
4. Reth, M. G., P. Ammirati, S. Jackson and F. W. Alt. 1985. Regulated progression of a cultured pre-B-cell line to the B-cell stage. Nature 317:353.
5. Loffert, D., S. Schaal, A. Ehlich, R. R. Hardy, Y. R. Zou, W. Muller, and K. Rajewsky. 1994. Early B-cell development in the mouse: insights from mutations introduced by gene targeting. Immunol. Rev. 137:135.
6. Ehlich, A. S. Schaal, H. Gu, D. Kitamura, W. Muller, and K. Rajewsky. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72:695.
7. Ehlich, A., and R. Kuppers. 1995. Analysis of immunoglobulin gene rearrangements in single B cells. Curr. Opin. Immunol. 7:281.
8. Alt, F. W. 1987. Development of the primary antibody repertoire. Science 238: 1079.
9. Hayashi, S., T. Kunisada, M. Ogawa, T. Sudo, H. Kodama, T. Suda, S. Nishikawa, and S. Nishikawa. 1990. Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules. J. Exp. Med. 171:1683.
10. Nussenzweig, M. C., A. C. Shaw, E. Sinn, D. B. Danner, K. L. Holmes, H. C. Morse, and P. Leder. 1987. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin μ. Science 236:816.
11. Rusconi, S., and G. Kohler. 1985. Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line. Nature 314:330.
12. Weaver, D., F. Costantini, K. T. Imanishi, and D. Baltimore. 1985. A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes. Cell 42:117.
13. Manz, J., K. Denis, O. Witte, R. Brinster, and U. Storb. 1988. Feedback inhibition of immunoglobulin gene rearrangement by membrane μ-, but not by secreted μ-heavy chains. [Published erratum appears in 1989 J. Exp. Med. 169:2269.] J. Exp. Med. 168:1363.
14. Chen, J., M. Trounstine, F. W. Alt, F. Young, C. Kurahara, J. F. Loring, and D. Huszar. 1993. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int. Immunol. 5:647.
15. Ha allotype gene that is deleted in Alicia mutants: somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences. Eur. J. Immunol. 21:411.
16. Spieker-Polet, H., P. Sethupathi, P. C. Yam, and K. L. Knight. 1995. Rabbit monoclonal antibodies: generating a fusion partner to produce rabbit-rabbit hybridomas. Proc. Natl. Acad. Sci. USA 92:9348.
17. Blin, N., and D. W. Stafford. 1976. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res. 3:2303.
18. Knight, K. L., P. H. Spieker, D. S. Kazdin, and V. T. Oi. 1988. Transgenic rabbits with lymphocytic leukemia induced by the c-myc oncogene fused with the immunoglobulin heavy chain enhancer. Proc. Natl. Acad. Sci. USA 85:3130.
19. H germ-line gene segments linked by overlapping cosmid clones of rabbit DNA. J. Immunol. 142:1351.
20. H allotypes: implications for the generation of antibody diversity. Cell 60:963.
21. H gene usage in rabbit B lineage cells. J. Immunol. 152:632.
22. Becker, R. S., and K. L. Knight. 1990. Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits. Cell 63:987.
23. H genes in leukemic rabbit B cells. Eur. J. Immunol. 20:397.
24. Benatar, T., L. Tkalec, and M. J. Ratcliffe. 1992. Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development. Proc. Natl. Acad. Sci. USA 89:7615.
25. Barth, C. F., and E. H. Humphries. 1988. Expression of v-rel induces mature B-cell lines that reflect the diversity of avian immunoglobulin heavy- and light-chain rearrangements. Mol. Cell. Biol. 8:5358.
26. H gene of the chicken with a high incidence in the D region. Cell 59:171.
27. Reynaud, C. A., V. Anquez, H. Grimal, and J. C. Weill. 1987. A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell 48:379.
28. Lauster, R., C. A. Reynaud, I. L. Martensson, A. Peter, D. Bucchini, J. Jami, and J. C. Weill. 1993. Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene. EMBO J. 12:4615.
29. Ferradini, L., H. Gu, A. De Smet, K. Rajewsky, C. A. Reynaud, and J. C. Weill. 1996. Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster. Science 271:1416.
30. Ferradini, L., C. A. Reynaud, R. Lauster, and J. C. Weill. 1994. Rearrangement of the chicken lambda light chain locus: a silencer/antisilencer regulation. Semin. Immunol. 6:165 (Rev.).
31. H formation. Ear. J. Immunol. 23:2365.
32. H recombination signal sequence targeting. J. Immunol. 157:4005.
33. Lauzurica, P., and M. S. Krangel. 1994. Temporal and lineage-specific control of T cell receptor α/δ gene rearrangement by T cell receptor α and δ enhancers. J. Exp. Med. 179:1913.
34. Chien, Y. H., M. Iwashima, D. A. Wettstein, K. B. Kaplan, J. F. Elliott, W. Born, and M. M. Davis. 1987. T-cell receptor δ gene rearrangements in early thymocytes. Nature 330:722.
35. H gene. Eur. J. Immunol. 19:1849.
36. H reading frame bias: evolutionary selection, antigen selection or both? Evolutionary selection. Immunol. Today 12:420 (Lett.).
37. Knight, K. L., and M. A. Crane. 1995. Development of the antibody repertoire in rabbits. Ann NY Acad. Sci. 764:198.
38. H gene segment rearrangements in lymphoid cells. Nature 312: 418.
39. H element reading frames. Cell 65:47.