Efficacy II. Estimation of a newly defined efficacy related parameter

European Journal of Pharmacology

Volumn 320, Issue 2-3, 1997, Pages 233-240

  Venter, Daniel P ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Agonist affinity; Carbachol; Efficacy estimation; Pharmacological method, new; Salbutamol

Indexed keywords

CARBACHOL; DRUG RECEPTOR; PARTIAL AGONIST; RECEPTOR RESERVE; SALBUTAMOL;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG EFFICACY; GUINEA PIG; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; TECHNIQUE;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ALBUTEROL; ANIMALS; BINDING, COMPETITIVE; CARBACHOL; DRUG ANTAGONISM; FEMALE; GUINEA PIGS; KINETICS; MALE; MUSCARINIC AGONISTS; PHARMACOLOGY; PINDOLOL; RECEPTOR, MUSCARINIC M3; RECEPTORS, CELL SURFACE; RECEPTORS, MUSCARINIC;

EID: 0031565272     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00900-4     Document Type: Article

References (12)

1. Ariëns, E.J., A.M. Simonis and J.M. Van Rossum, 1964, Drug-receptor interaction: interaction of one or more drugs with one receptor system, in: Molecular Pharmacology, Vol. 1, ed. E.J. Ariëns (Academic Press, New York, NY) p. 119.
2. 2-receptors, Br. J. Pharmacol. 114, 1507.
3. Furchgott, R.F., 1972, The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory, in: Handbook of Experimental Pharmacology. Vol. 33, eds. H. Blashko and E. Muscholl (Springer, New York, NY) p. 283.
4. Kenakin, T.P., 1985, The quantification of relative efficacy of agonists, J. Pharmacol. Methods 13, 281.
5. Kenakin, 1987, Agonist affinity, in: Pharmacologic Analysis of Drug-Receptor Interaction, 1st edn. (Raven Press, New York, NY) p. 163.
6. Kenakin, 1993, Drug-receptor theory, in: Pharmacologic Analysis of Drug-Receptor Interaction, 2nd edn. (Raven Press, New York, NY) p. 1.
7. Stephenson, R.P., 1956, A modification of receptor theory, Br. J. Pharmacol. 11, 379.
8. Van den Brink, F.G., 1977, General theory of drug-receptor interactions. Drug receptor interaction models. Calculation of drug parameters, in: Kinetics of Drug Action, Vol. 47, ed. J.M. Van Rossum (Springer, Berlin) p. 169.
9. Van Rossum, J.M., 1963, Cumulative dose-response curves, Arch. Int. Pharmacodyn. 143, 299.
10. Venter, D.P., 1994, Indirectly acting agonists. A model for the functional interaction of released endogenous double agonists, Eur. J. Pharmacol. 251, 209.
11. Venter, D.P., 1996, New methods for determining dissociation constants of agonist-receptor complexes, Eur. J. Pharmacol. 303, 235.
12. Venter, D.P., 1997, Efficacy I. A new method for estimating relative efficacy of full agonists via a newly defined efficacy related parameter, Eur. J. Pharmacol. 320, 223.