Competitive NMDA receptor antagonist, CGP 40116, substitutes for the discriminative stimulus effects of ethanol

European Journal of Pharmacology

Volumn 314, Issue 3, 1996, Pages 277-280

  Bienkowski, Przemyslaw ^a,b   Stefanski, Roman ^a   Kostowski, Wojciech ^a,b  

^a INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

^b Medical High School   (Poland)

Author keywords

Drug discrimination; Ethanol; NMDA receptor antagonist; Rat

Indexed keywords

2 AMINO 4 METHYL 5 PHOSPHONO 3 PENTENOIC ACID; ALCOHOL; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; DISCRIMINATIVE STIMULUS; DRUG DISCRIMINATION; ENANTIOMER; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; BINDING, COMPETITIVE; DISCRIMINATION LEARNING; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; EXCITATORY AMINO ACID ANTAGONISTS; MALE; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; STEREOISOMERISM;

EID: 0030608334     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00658-9     Document Type: Article

References (14)

1. Danysz, W., W. Dyr, E. Jankowska, S. Glazewski and W. Kostowski, 1992, The involvement of NMDA receptors in acute and chronic effects of ethanol, Alcohol. Clin. Exp. Res. 16, 499.
2. Fagg, G.E., H.R. Olpe, M.F. Pozza, J. Band, M. Steinmann, M. Schitz, C. Portet, P. Baumann, K. Thedinga, H. Bittiger, H. Allgeier, R. Heckendorn, C. Angst, D. Brundish and J.G. Dingwall, 1990, CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptors antagonists with oral activity, Br. J. Pharmacol. 99, 791.
3. Grant, K.A. and G. Colombo, 1993, Discriminative stimulus effects of ethanol: effect of training dose on the substitution of N-methyl-D-aspartate antagonists, J. Pharmacol. Exp. Ther. 264, 1214.
4. Grant, KA., G. Colombo and B. Tabakoff, 1991a, Competitive and non-competitive antagonists of the NMDA receptor complex have ethanol-like discriminative stimulus effects in rats. Alcohol. Clin. Exp. Res. 15, 321.
5. Grant, K.A., J.S. Knisely, B. Tabakoff, J.E. Barrett and R.L. Balster, 1991b, Ethanol-like discriminative stimulus effects of non-competitive N-methyl-D-aspartate antagonists, Behav. Pharmacol. 2, 87.
6. Hoffman, P.L., C.S. Rabe, F. Moses and B. Tabakoff, 1989, N-Methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production, J. Neurochem. 52, 1937.
7. Koek, W., M.S. Kleven and F.C. Colpaert, 1995, Effects of the NMDA antagonist, dizocilpine, in various drug discriminations: characterization of intermediate levels of drug lever selection, Behav. Pharmacol. 6, 590.
8. Lovinger, D.M., G. White and F. Weight, 1989, Ethanol inhibits NMDA-activated ion current in hippocampal neurones, Science 243, 1721.
9. Sanger, D.J., 1993, Substitution by NMDA antagonists and other drugs in rats trained to discriminate ethanol, Behav. Pharmacol. 4, 523.
10. A and NMDA receptor function in the rat brain, Alcohol. Clin. Exp. Res. 17, 115.
11. Schmutz, M., A. Jeker, K. Klebs, C. Portet, M. Pozza, G.E. Fagg, R. Heckendorn and H. Allgeier, 1991, CGP 40116/CGP 43487: competitive N-methyl-D-aspartate receptor antagonists with potent oral anti-convulsant activity, Epilepsia 32 (Suppl. 1), 59.
12. Shelton, K.L. and R.L. Balster, 1994, Ethanol drug discrimination in rats: substitution with GABA agonists and NMDA antagonists, Behav. Pharmacol. 5. 441.
13. Simson, P.E., H.E. Criswell, K.B. Johnson, R.E. Hicks and G.R. Breese, 1991, Ethanol inhibits NMDA-evoked electrophysiological activity in vivo, J. Pharmacol. Exp. Ther. 257, 225.
14. Tallarida, R.J. and R.B. Murray. 1987. Manual of Pharmacological Calculations, 2nd edn. (Springer, New York, NY).