A new synthesis of α-tetralones

Tetrahedron Letters

Volumn 38, Issue 10, 1997, Pages 1759-1762

  Liard, Annie ^a   Quiclet Sire, Béatrice ^a   Saicic, Radomir N ^a   Zard, Samir Z ^a,b  

^a CNRS   (France)

^b LABORATOIRE DE SYNTHÈSE ORGANIQUE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 TETRALONE DERIVATIVE;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; REACTION ANALYSIS; STOICHIOMETRY;

EID: 0031562426     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00184-6     Document Type: Article

References (29)

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28. 11. Typical experimental procedure: To a degassed, refluxing solution of xanthate 5 in 1,2-dichloroethane (0.1 mmole / ml) is added dilauoyl peroxide in 5 mole% portions every hour until consumption of the starting material (1-1.5 mole-equivalents are usually needed). Alternatively, the higher boiling chlorobenzene can be used and a 0.1M peroxide added over 0.5-1 hour. In both cases, the reaction is regularly monitored for the disappearance of the starting material by thin-layer chromatography. Upon completion, the solvent is removed under partial vacuum and the residue purified by chromatography.
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