Inhibition of inducible nitric oxide synthase expression and stimulation of the endothelial formation of nitric oxide most likely accounts for the protective effect of 2-(allylthio)pyrazine in a murine model of endotoxemia

Biochemical and Biophysical Research Communications

Volumn 239, Issue 1, 1997, Pages 310-315

  Kim, Nak Doo ^a   Kang, Keon Wook ^a   Kim, Sang Geon ^b   Schini Kerth, V B ^c  

^a Seoul National University   (South Korea)

^b Duksung Women's University   (South Korea)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 ALLYLTHIOPYRAZINE; ANTIOXIDANT; CYCLIC GMP; LIPOPOLYSACCHARIDE; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; PHENYLEPHRINE; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD LEVEL; CELL STIMULATION; CONTROLLED STUDY; ENDOTHELIUM; ENDOTOXEMIA; ENZYME INDUCTION; ENZYME INHIBITION; GENE INDUCTION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; MURINAE;

EID: 0031561414     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1997.7406     Document Type: Article

References (26)

1. 1. Knowles, R. G., and Moncada, S. (1994) Biochem. J. 298, 249-258.
2. 2. Moncada, S., and Higgs, A. (1993) N. Engl. J. Med. 329, 2002-2012.
3. 3. Thiemermann, C. (1994) Adv. Pharmacol. 28, 45-79.
4. 4. Julou-Schaeffer, G., Gray, G. A., Fleming, I., Scott, C., Parratt, J. R., and Stoclet, J. C. (1990) Am. J. Physiol. 259, H1038-H1043.
5. 5. Xie, Q.-w., Kashiwabara, Y., and Nathan, C. (1994) J. Biological Chem. 269, 4705-4708.
6. 6. Loegering, D. J., Richard, C. A. H., Davison, C. B., and Wirth, G. A. (1995) Life Science 57, 169-176.
7. 7. Mülsch, A., Schray-Utz, B., Mordvintcev, P. I., Hauschildt, S., and Busse, R. (1993) FEBS lett. 321, 215-218.
8. 8. Sherman, M. P., Aeberhard, E. E., Wong, V. Z., Griocavage, J. M., and Ignarro, L. J. (1993) Biochem. Biophys. Res. Comm. 191, 1301-1308.
9. 9. Kim, N. D., Kwak, M. K., and Kim, S. G. (1997) Biochem. Pharmacol. 53, 261-269.
10. 10. Kim, S. G., Cho, J. Y., Choi, S. H., and Kim, N. D. (1996) Yakhak Hoeji 40, 727-733.
11. 11. Beckman, J. S., and Conger, K. A. (1995) Method: A Comparison to Method in Enzymology 7, 35-39.
12. 12. Braman, R. S., and Hendrix, S. A. (1989) Anal. Chem. 61, 2715-2718.
13. 13. Kim, N. D., Kang, S. Y., and Schini, V. B. (1994) Gen. Pharmacol. 25, 1071-1077.
14. 14. Kang, S. Y., Schini-Kerth, V. B., and Kim, N. D. (1995) Life Sci. 56, 1577-1586.
15. 15. Laemmli, U. K. (1970) Nature (London) 227, 680-685.
16. 16. Kwak, M. K., Kim, S. G., Kwak, J. Y., Novak, R. F., and Kim, N. D. (1994) Biochem. Pharmacol. 47, 531-539.
17. 17. Mckenna, T. M. (1990) J. Clin. Invest. 86, 160-168.
18. 18. Busse, R., and Mülsch, A. (1990) FEBS Lett. 275, 87.
19. 19. Beasley, D., Cohen, R. A., and Levinsky N. G. (1989) J. Clin. Invest. 83, 331-335.
20. 20. Shini-Kerth, V. B., Bara, A., Mülsch, A., and Busse, R. (1994) Eur. J. Pharmacol. 265, 83-87.
21. 21. Ochoa, J. B., Udekwu, A. O., Billiar, T. R., Curran, R. D., Cerra, F. B., Simmons, R. L., and Peitzman, A. B. (1991) Ann. Surg. 214, 621-626.
22. 22. Evans, T., Carpenter, A., Kinderman, H., and Cohen, J. (1993) Circ. Shock 41, 77-81.
23. 23. Tracy, W. R., Tse, J., and Carter, G. (1995) J. Pharmacol. Exp. Ther. 272, 1011-1015.
24. 24. Rees, D. D., Palmer, R. M. J., and Moncada, S. (1989) Proc. Natl. Acad. Sci. 86, 3375-3378.
25. 25. Kubes, P., Suzuki, M., and Granger, D. N. (1991) Proc. Natl. Acad. Sci. 88, 4651-4655.
26. 26. Busse, R., Lückhoff, A., and Bassenge, E. (1987) Naunyn-Schmiedeberg's Archives of Pharmacology 336, 566-571.