Metallothionein induction in fetal rat brain and neonatal primary astrocyte cultures by in utero exposure to elemental mercury vapor (Hg0)

Brain Research

Volumn 778, Issue 1, 1997, Pages 222-232

  Aschner, M ^a   Lorscheider, F L ^b   Cowan, K S ^a   Conklin, D R ^a   Vimy, M J ^b   Lash, L H ^c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Astrocyte; Biomarker; Brain; In utero; Mercury vapor Hg0; Metallothionein; Rat

Indexed keywords

CELL MARKER; MERCURY; METALLOTHIONEIN;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN BLOOD FLOW; CELL CULTURE; CYTOTOXICITY; DEPRESSION; DNA PROBE; FEMALE; FETUS; GENE EXPRESSION; IMMUNOREACTIVITY; INSOMNIA; IRRITABILITY; NONHUMAN; NORTHERN BLOTTING; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; RNA HYBRIDIZATION; TREMOR;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BLOTTING, NORTHERN; BLOTTING, WESTERN; BRAIN; CELLS, CULTURED; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GESTATIONAL AGE; GLUTATHIONE; MERCURY; METALLOTHIONEIN; NERVE TISSUE PROTEINS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031555407     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01095-0     Document Type: Article

References (54)

1. Andrews G.K. Regulation of metallothionein gene expression. Prog. Food Nutrit. Sci. 14:1990;193-258.
2. Aschner M., Du Y.-L., Gannon M., Kimelberg H.K. Methylmercury-induced alterations in excitatory amino acid efflux from rat primary astrocyte cultures. Brain Res. 602:1993;181-186.
3. Aschner M., Mullaney K.J., Wagoner D., Lash L.H., Kimelberg H.K. Intracellular glutathione (GSH) levels modulate mercuric chloride (MC-) and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures. Brain Res. 664:1994;133-140.
4. Aschner M., Rising L., Vitarella D., Mullaney K.J. Differential sensitivity of neonatal rat astrocyte cultures to mercuric chloride (MC) and methylmercury (MeHg): Studies on K and amino acid transport, and metallothionein (MT) induction. neurotoxicology. 17:1996;107-116.
5. Aschner M. The functional significance of brain metallothioneins. FASEB J. 10:1996;1129-1136.
6. Barbu V., Dautry F. Northern blot normalization with a 28S rRNA oligonucleotide probe. Nucleic Acids Res. 17:1989;7115-7118.
7. Bauman J.W., McKim J.M. Jr., Liu J., Klaassen C.D. Induction of metallothionein by diethyl maleate. Toxicol. Appl. Pharmacol. 114:1992;188-192.
8. Blaauwgeers H.G., Sillevis-Smitt P.A., De-Jong J.A., Troost D. Distribution of metallothionein in the human central nervous system. Glia. 8:1993;62-70.
9. 2 and methylmercury in astrocytes: Selectivity and reversibility. J. Neurochem. 53:1989;1228-1237.
10. Charleston J.S., Bolender R.P., Mottet N.K., Body R.L., Vahter M.E., Burbacher T.M. Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure. Toxicol. Appl. Pharmacol. 129:1994;196-206.
11. Chen R.W., Ganther H.E., Hoekstra W.G. Studies on the binding of methylmercury by thionein. Biochem. Biophys. Res. Commun. 51:1973;383-390.
12. Chmielnicka J., Brzeznicka E.A. The influence of selenium on the level of mercury and metallothionein in rat kidneys in prolonged exposure to different mercury compounds. Bull. Environ. Contamin. Toxicol. 19:1978;183-190.
13. Choudhuri S., Kramer K.K., Berman N.E., Dalton T.P., Andrews G.K., Klaassen C.D. Constitutive expression of metallothionein genes in mouse brains. Toxicol. Appl. Pharmacol. 131:1995;144-154.
14. Dalton T., Palmiter R.D., Andrews G.K. Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant-response element and metal response promoter elements. Nucleic Acids Res. 22:1994;5016-5023.
15. Dave V., Mullaney K.J., Goderie S., Kimelberg H.K., Aschner M. Astrocytes as mediators of methylmercury (MeHg) neurotoxicity: Effects on D-aspartate and serotonin uptake. Dev. Neurosci. 16:1994;222-231.
16. Durnam D.M., Palmiter R.D. Induction of metallothionein-I mRNA in cultured cells by heavy metals and iodoacetate: Evidence for gratuitous inducers. Mol. Cell. Biol. 4:1984;484-491.
17. Falnoga I., Kregar I., Skreblin M., Tusek-Znidaric M., Stegnar P. Interactions of mercury in rat brain. Biol. Trace Element Res. 37:1993;71-83.
18. Fariss M.W., Reed D.J. High-performance liquid chromatography of thiols and disulfides: Dinitrophenol derivatives. Methods Enzymol. 143:1987;101-109.
19. Folbergova J., Rehncrona S., Siesjo B.K. Oxidized and reduced glutathione in the rat brain under normopoxic and hypoxic conditions. J. Neurochem. 32:1979;1621-1627.
20. Ganther H.E. Modification of methylmercury toxicity and metabolism by selenium and vitamin E: Possible mechanisms. Environ. Health Perspect. 25:1978;71-76.
21. Garman R.H., Weiss B., Evans H.L. Alkylmercurial encephalopathy in the monkey; a histopathologic and autoradiographic study. Acta Neuropathol. (Berlin). 32:1975;61-74.
22. Hager L.G., Palmiter R.D. Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids. Nature. 291:1981;340-342.
23. Heuchel R., Radtke F., Georgiev O., Stark G., Aguet M., Schaffner W. The transcription factor MTF- 1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J. 13:1994;2870-2875.
24. Hidalgo J., Garcia A., Oliva A.M., Giralt M., Gasull T., Gonzales B., Milnerowicz H., Wood A., Bremner I. Effect of zinc, copper and glucocorticoids on metallothionein levels of cultured neurons and astrocytes from rat brain. Chem.-Biol. Interact. 93:1994;197-219.
25. Hughes W.H. A physiochemical rationale for the biological activity of mercury and its compounds. Ann. NY Acad. Sci. 65:1957;454-460.
26. Kägi J.H.R., Overview of Metallothionein, in: J.F. Riordan, B.L. Vallee (Eds.), Methods in Enzymology. Metallobiochemistry, Vol. 205, Part B, Metallothionein and Related Molecules, Academic Press, New York, NY, 1991, pp. 613-626.
27. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
28. Lane L.C. A simple method for stabilizing protein-sulfhydryl groups during SDS-gel electrophoresis. Anal. Biochem. 86:1978;655-664.
29. Langworth S., Elinder C.-G., Akesson A. Mercury exposure from dental fillings. I. Mercury concentrations in blood and urine. Swed. Dent. J. 12:1988;69-70.
30. Lash L.H., Tokarz J.J. Oxidative stress in isolated rat renal proximal and distal tubular cells. Am. J. Physiol. 259:1990;F338-F347.
31. Lorscheider F.L., Vimy M.J., Summers A.O. Mercury exposure from `silver' fillings: emerging evidence questions a traditional dental paradigm. FASEB J. 9:1995;504-508.
32. Masters B.A., Quaife C.J., Erickson J.C., Kelly E.J., Froelick G.J., Zambrowicz B.P., Brinster R.L., Palmiter R.D. Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles. J. Neurosci. 14:1994;5844-5857.
33. Mokrasch L.C., Teschke E.J. Glutathione content of cultured cells and rodent brain regions: a specific fluorometric assay. Anal. Biochem. 140:1984;506-509.
34. Molin M., Marklund S., Bergman B., Bergman M., Stenman E. Plasma-selenium, glutathione peroxidase in erythrocytes and mercury in plasma in patients allegedly subject to oral galvanism. Scand. J. Dent. Res. 95:1987;328-334.
35. Nishimura N., Nishimura H., Ghaffar A., Tohyama C. Localization of metallothionein in the brain of rat and mouse. J. Histochem. Cytochem. 40:1992;309-315.
36. Nylander M., Friberg L., Lind B. Mercury concentrations in the human brain in relation to exposure from dental amalgam fillings. Swed. Dent. J. 11:1987;179-187.
37. Olstad M.L., Holland R.I., Wandel L., Hensten Petersen A. Correlation between amalgam restorations and mercury concentrations in urine. J. Dent. Res. 66:1987;1179-1182.
38. Palmiter R.D. Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1. Proc. Natl. Acad. Sci. USA. 91:1994;1219-1223.
39. Pendergrass J.C., Haley B.E., Vimy M.J., Winfield S.A., Lorscheider F.L. Mercury vapor inhalation inhibits binding of GTP to tubulin in rat brain: similarity to a molecular lesion in Alzheimer diseased brain. Neurotoxicology. 18:1997;315-324.
40. Radtke F., Heuchel R., Georgiev O., Hergersberg M., Gariglio M., Dembic Z., Schaffner W. Cloned transcription factor MTF-I activates the mouse metallothionein promoter. EMBO J. 12:1993;1355-1362.
41. Sambrook S., Fritsch E.F., Maniatis T., Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Press, Cold Spring Harbor, NY, 1989.
42. Shiraga H., Pfeiffer R.F., Ebadi M. The effects of 6-hydroxydopamine and oxidative stress on the level of brain metallothionein. Neurochem. Int. 23:1992;561-566.
43. Slivka A., Spina M.B., Cohen G. Reduced and oxidized glutathione in human and monkey brain. Neurosci. Lett. 74:1987;112-118.
44. Suzuki K., Nakajima K., Kawaharada U., Uehara U., Hara F., Otaki N., Kimura M., Tamura Y. Metallothionein in the human brain. Acta Histochem. Cytochem. 25:1992;617-622.
45. Vallee B.L., Maret V., The functional and potential functions of metallothioneins: A personal perspective, in: K.T. Suzuki, N. Imura, M. Kimura (Eds.), Metallothionein III: Biological Roles and Medical Implications, Birkhauser, Berlin, 1993, pp. 1-27.
46. Vimy M.J., Lorscheider F.L. Serial measurements of intra-oral air mercury: Estimation of daily dose from dental amalgam. J. Dent. Res. 64:1985;1072-1075.
47. Vimy M.J., Hooper D.E., King W.W., Lorscheider F.L. Mercury from maternal `silver' fillings in sheep and human breast milk: A source of neonatal exposure. Biol. Trace Element Res. 56:1997;143-152.
48. Warfvinge K., Berlin M., Logdberg B. The effect on pregnancy outcome and fetal brain development of prenatal exposure to mercury vapor. Neurotoxicology. 15:1994;956.
49. Warfvinge K., Hua J., Logdberg B. Mercury distribution in cortical areas and fiber systems of the neonatal and maternal adult cerebrum after exposure of pregnant squirrel monkeys to mercury vapor. Environ. Res. 67:1994;196-208.
50. WHO, Environmental Health Criteria, 118, Inorganic mercury, World Health Organization, Geneva, 1991.
51. Winfield S.A., Boyd N.D., Vimy M.J., Lorscheider F.L. Measurement of total mercury in biological specimens by cold vapor atomic fluorescence spectrometry. Clin. Chem. 40:1994;206-210.
52. Wong K.L., Klaassen C.D. Relationship between liver and kidney levels of glutathione and metallothionein in rats. Toxicology. 19:1981;39-47.
53. Yagle M.K., Palmiter R.D. Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids. Mol. Cell. Biol. 5:1985;291-294.
54. Young J.K., Garvey J.S., Huang P.C. Glial immunoreactivity for metallothionein in the rat brain. Glia. 4:1991;602-610.