Alkyl-dihydroxyacetonephosphate synthase

Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

Volumn 1348, Issue 1-2, 1997, Pages 35-44

  Van den Bosch, H ^a   De Vet, E C J M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Alkyl dihydroxyacetonephosphate synthase; Amino acid sequence; CDNA cloning; Deficiency in peroxisomal disorders; Ether phospholipid; Guinea pig liver; Membrane association; Peroxisomal targeting signal 2; Peroxisome; Presequence; Purification

Indexed keywords

ALKYLGLYCERONE PHOSPHATE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; DISORDERS OF PEROXISOMAL FUNCTIONS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEFICIENCY; ENZYME PURIFICATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION;

CAVIA PORCELLUS; MAMMALIA; SUS SCROFA;

EID: 0031552992     PISSN: 00052760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2760(97)00107-0     Document Type: Review

References (37)

1. F. Snyder, T. Lee, R.L. Wykle, Ether-linked glycerolipids and their bioactive species: Enzymes and metabolic regulation, in: A.N. Martonosi (Ed.), The Enzymes of Biological Membranes, 2nd ed., vol. 2, Plenum Press, New York, 1985, pp. 1-58.
2. Hajra A.K. Glycerolipid biosynthesis in peroxisomes (microbodies). Progr. Lipid Res. 34:1995;343-364.
3. Hajra A.K. Acyl-dihydroxyacetonephosphate: precursor of alkyl ethers. Biochem. Biophys. Res. Commun. 39:1970;1037-1044.
4. Wykle R.L., Piantadosi C., Snyder F. The role of acyl-dihydroxyacetonephosphate, NADH and NADPH in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor. J. Biol. Chem. 247:1972;2944-2948.
5. Friedberg S.J., Heifetz A. The formation of tritiated O-alkyl lipid from acyl-dihydroxyacetone phosphate in the presence of tritiated water. Biochemistry. 14:1975;570-574.
6. Snyder F., Clark M., Piantadosi C. Biosynthesis of alkyl lipids: displacement of the acyl moiety of acyl-dihydroxyacetonephosphate with fatty alcohol analogs. Biochem. Biophys. Res. Commun. 53:1973;350-356.
7. Rock C.D., Fitzgerald V., Snyder F. Activation of alkyl-dihydroxyacetonephosphate synthase by detergents. Arch. Biochem. Biophys. 181:1977;172-177.
8. Davis P.A., Hajra A.K. Assay and properties of the enzyme catalyzing the biosynthesis of 1-O-alkyl-dihydroxyacetone 3-phosphate. Arch. Biochem. Biophys. 211:1981;20-29.
9. Zomer A.W.M., de Weerd W.F.C., Langeveld J., van den Bosch H. Ether lipid synthesis: purification and identification of alkyl dihydroxyacetone phosphate synthase from guinea pig liver. Biochim. Biophys. Acta. 1170:1993;189-196.
10. Schrakamp G., Schutgens R.B.H., Wanders R.J.A., Heymans H.S.A., Tager J.M., van den Bosch H. Alkyl-dihydroxyaceteonephosphate synthase in human fibroblasts and its deficiency in Zellweger syndrome. J. Lipid Res. 26:1985;867-873.
11. Zomer A.W.M., Opperdoes F.R., van den Bosch H. Alkyl-dihydroxyacetonephosphate synthase in glycosomes of Trypanosoma brucei. Biochim. Biophys. Acta. 1257:1995;167-173.
12. Van den Bosch H., Schutgens R.B.H., Wanders R.J.A., Tager J.M. Biochemistry of peroxisomes. Annu. Rev. Biochem. 61:1992;157-197.
13. Felde R., Spitteller G. Search for plasmalogens in plants. Chem. Phys. Lipids. 71:1994;109-113.
14. Hajra A.K., Bishop J.E. Glycerolipid biosynthesis in peroxisomes via the acyl-dihydroxyacetonephosphate pathway. Ann. NY Acad. Sci. 386:1982;170-182.
15. Heymans H.S.A., Schutgens R.B.H., Tan R., van den Bosch H., Borst P. Severe plasmalogen deficiency in tissues of infants without peroxisomes (Zellweger syndrome). Nature. 306:1983;69-70.
16. Zoeller R.A., Raetz C.H.R. Isolation of animal cell mutants deficient in plasmalogen biosynthesis and peroxisome assembly. Proc. Natl. Acad. Sci. USA. 83:1986;5170-5174.
17. A.K. Hajra, M.K. Ghosh, K.O. Webber, N.S. Datta, The peroxisomal enzymes of glycerolipid metabolism, in: L. Freysz, H. Dreyfus, R. Massarelli, S. Gatt (Eds.), Enzymes of Lipid Metabolism II, Plenum Press, New York, 1986, pp. 199-207.
18. Hardeman D., van den Bosch H. Rat liver dihydroxyacetonephosphate acyltransferase: enzyme characteristics and localization studies. Biochim. Biophys. Acta. 963:1988;1-9.
19. Fujiki Y., Fowler S., Shio N., Hubbard A.L., Lazarow P.B. Polypeptide and phospholipid composition of the membrane of rat liver peroxisomes: Comparison with endoplasmic reticulum and mitochondrial membranes. J. Cell Biol. 93:1982;103-110.
20. Hardeman D., Versantvoort C., van den Brink J.M., van den Bosch H. Studies on peroxisomal membranes. Biochim. Biophys. Acta. 1027:1990;149-154.
21. Brown A., Snyder F. Alkyldihydroxyaceteonephosphate synthase. Methods Enzymol. 209:1992;377-384.
22. Brown A.J., Snyder F. Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism. J. Biol. Chem. 257:1982;8835-8839.
23. Horie S., Das A.K., Hajra A.K. Alkyldihydroxyacetonephosphate synthase from guinea pig liver peroxisomes. Methods Enzymol. 209:1992;385-390.
24. Snyder F., Rainey W.T. Jr., Blank M.L., Christie W.H. The source of oxygen in the ether bond of glycerolipids. J. Biol. Chem. 245:1970;5853-5856.
25. 18O studies of fatty acid release from acyl-dihydroxyacetone phosphate. Biochemistry. 24:1985;8012-8016.
26. Friedberg S.J., Satsangi N., Weintraub S.T. Stereochemistry of the acyl-dihydroxyacetonephosphate acyl exchange reaction. J. Lipid Res. 32:1991;259-266.
27. 3H]dihydroxyacetone-P by purified alkyldihydroxyacetone-P synthase in the absence of acylhydrolase activity. J. Biol. Chem. 258:1983;4184-4189.
28. Horie S., Utsumi K., Suga T. Changes in the activities of dihydroxyacetone phosphate and glycerol-3-phosphate acyltransferases in rat liver under various conditions. Biochim. Biophys. Acta. 1042:1990;294-300.
29. Hardeman D., Zomer A.W.M., Schutgens R.B.H., Tager J.M., van den Bosch H. Effect of peroxisome proliferation on ether phospholipid biosynthesizing enzymes in rat liver. Int. J. Biochem. 22:1990;1413-1418.
30. De Vet E.C.J.M., Zomer A.W.M., Lahaut G.J.H.T.J., van den Bosch H. Polymerase chain reaction-based cloning of alkyl-dihydroxyacetonephosphate synthase complementary DNA from guinea pig liver. J. Biol. Chem. 272:1997;798-803.
31. Kozak M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:1987;8125-8148.
32. De Vet E.C.J.M., van den Broek B.T.E., van den Bosch H. Nucleotide sequence of human alkyl-dihydroxyacetonephosphate synthase cDNA reveals the presence of a peroxisomal targeting signal 2. Biochim. Biophys. Acta. 1346:1997;25-29.
33. Swinkels B.W., Gould S.J., Bodnar A.G., Rachubinski R.A., Subramani S. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. EMBO J. 10:1991;3255-3262.
34. Rachubinski R.A., Subramani S. How proteins penetrate peroxisomes. Cell. 83:1995;525-528.
35. De Vet E.C.J.M., Biermann J., van den Bosch H. Immunological localization and tissue distribution of alkyldihydroxyacetonephosphate synthase and deficiency of the enzyme in peroxisomal disorders. Eur. J. Biochem. 247:1997;511-517.
36. Motley A.M., Hettema E.H., Distel B., Tabak H.F. Differential protein import deficiencies in human peroxisome assembly disorders. J. Cell Biol. 125:1994;755-767.
37. Slawecki M. L, Dodt G., Steinberg S., Moser A.B., Moser H.W., Gould S.J. Identification of three distinct peroxisomal protein import defects in patients with peroxisome biogenesis disorders. J. Cell Sci. 108:1995;1817-1829.