Structure, dynamics, and topological orientation of the polyether, lonophore antibiotic monensin, in a micellar environment

Biopolymers - Nucleic Acid Sciences Section

Volumn 42, Issue 7, 1997, Pages 759-769

  Mercuric, Eduarde ^a   Pellegrini, Maria ^b   Mierke, Dale F ^a  

^a CLARK UNIVERSITY   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Antibiotic; Cation transport; Conformation of antibiotic; Micelles; Nmr structure refinement; Spectroscopy in micelles; Structure in micelles

Indexed keywords

CELL MEMBRANES; COMPUTATIONAL METHODS; COMPUTER SIMULATION; CONFORMATIONS; MICELLES; MOLECULAR DYNAMICS; MOLECULAR ORIENTATION; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYETHERS; RELAXATION PROCESSES;

MONENSIN; NUCLEAR OVERHAUSER ENHANCEMENT (NOE);

ANTIBIOTICS;

IONOPHORE; MONENSIN; POLYETHER;

ARTICLE; CATION TRANSPORT; DRUG CONFORMATION; DRUG STRUCTURE; DYNAMICS; MICELLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; STRUCTURE ANALYSIS;

EID: 0031542249     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0282(199712)42:7<759::aid-bip2>3.0.co;2-s     Document Type: Article

References (27)

1. Agtagrap, A., Chamberlin, J., W., Pinkerton, M. & Steinrauf, L. (1967) J. Am. Chem. Soc. 89, 57375739.
2. Sandeaux, R., Sandeaux, J., Gavach, C. & Brun, B. (1982) Biochim. Biophys Acta 684, 127-132.
3. Tsukube, H., Takagi, K., Higashiyama, T., Iwachido, T. & Hayama, N. (1994) Inorg. Chem. 33, 29842987.
4. Inabayashi, M., Miyauchi, S., Kamo, N. & Jin, T. (1995) Biochemistry 34, 3455-3460.
5. Rochdi, M., Delort, A. M., Guyot, J., Sancelme, M., Gibot, S., Gourcy, J. G., Dauphin, G., Gumila, C., Vial, H. & Jeminet, G. (1996) J. Med. Chem. 39, 588-595.
6. Turner, D. L. (1995) J. Magn. Reson. Ser. B 108, 137-142.
7. van de Yen, F. J. M., van Os, J. W. M., Aelen, J. M. A., Wymenga, S. S., Remerowsky, M. L., Konings, R. N. H. & Hilbers, C. W. ( 1993) Biochemistry 32. 8322-8328.
8. Brown, L. R., Bösch, C. & Wüthrich, K. ( 1981 ) Biochim. Biophys. Acta 642, 296-312.
9. Papavoine, C. H. M., Konings, R. N. H., Hilbers, C. W. & van de Yen, F. J. M. (1994) Biochemistry 33. 12990-12997.
10. Cuba, W., Haessner, R., Breiphol, G., Henke, S., Knolle, J., Santagada, V. & Kessler, H. (1994) J. Am. Chem. Soc. 116, 7532-7540.
11. Pellegrini, M. & Mierke, D. F. (1997) J. Med. Chem. 40,99-104.
12. Rance, M., S0rensen, O. W., Bodenhausen, G., Wagner, G., Ernst, R. R. & Wüthrich, K. (1983) Biochem. Biophys. Res. Commun. 117, 458-479.
13. Braunschweiler, L. & Ernst, R. R. (1983) J. Magn. Reson. 53,521-528.
14. Bax, A. & Davis, D. G. (1985) J. Magn. Reson. 65, 355-360.
15. Jeener, J., Meier, B. H., Bachmann, P. & Ernst, R. R. (1979) J. Chem. Phys. 71, 4546-4553.
16. Macura, S., Huang, Y., Suter, D. & Ernst, R. R. (1981) J. Magn. Reson. 43, 259-281.
17. States, D. J., Haberkorn, R. A. & Rüben, D. J. (1982) J. Magn. Reson. 48, 286-292.
18. Muller, L. (1979) J. Am. Cliem. Soc. 101, 44814484.
19. Bax, A. & Subramanian, S. (1986) J. Magn. Reson. 67, 512-569.
20. Wüthrich, K., Billeter, M. & Braun, W. (1983) J. Mol. Biol. 169, 949-961.
21. Havel, T. F. (1991) Prag. Biophys. Mol. Biol. 56, 43-78.
22. Grippen, G. M., & Havel, T. F. (1988) Distance Geometry and Molecular Conformation, Research Studies Press, Ltd., Somerset, England.
23. Kaptein, R., Boelens, R., Scheck, R. M. & van Gunsteren, W. F. (1988) Biochemistry 27, 53895395.
24. Mierke, D. F., Geyer, A. & Kessler, H. (1994) Int. J. Peptide Protein Res. 44, 325-331.
25. Berendsen, H. J. C., Postma, J. P. M., van Gunsteren, W. F. & Hermans, J. ( 1981 ) Intermolecular Forces, Pullman, B., Ed., Reidel, Dordrecht, The Nederlands, pp. 331-342.
26. Rebertus, D. W., Berne, B. J. & Chandler, D. (1979) J. Chem. Phys. 70, 3395-3400.
27. Ajaz, A., A., Robinson, A., J. & Turner, L., D. (1987) J. Chem. Soc. Perkin Trans. I, 27-36.