Detection and replication of linkage to a complex human disease

Genetic Epidemiology

Volumn 14, Issue 6, 1997, Pages 1023-1028

  Moldin, Steven O ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Extreme discordant sib pairs; Multivariate genetic analysis; Sampling

Indexed keywords

CHROMOSOME PAIRING; CONFERENCE PAPER; DISEASE ASSOCIATION; GENE LOCUS; GENE REPLICATION; GENE SEGREGATION; GENETIC ANALYSIS; GENETIC LINKAGE; HUMAN; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; QUANTITATIVE TRAIT; SIBLING;

CHROMOSOME MAPPING; COMPUTER SIMULATION; FEMALE; GENETIC DISEASES, INBORN; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); MALE; MEIOSIS; MULTIVARIATE ANALYSIS; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE; RISK FACTORS;

EID: 0031470795     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1997)14:6<1023::AID-GEPI77>3.0.CO;2-K     Document Type: Conference Paper

References (8)

1. Borecki IB, Lathrop GM, Bonney GE, Yaouang J, Rao DC (1990): Combined segregation and linkage analysis of genetic hemochromatosis using affection status, serum iron, and HLA. Am J Hum Genet 47:542-550.
2. Carey G, Williamson J (1991): Linkage analysis of quantitative traits: increased power by using selected samples. Am J Hum Genet 49:786-796.
3. Eaves L, Meyer J (1994): Locating human quantitative trait loci: guidelines for the selection of sibling pairs for genotyping. Behav Genet 24:443-455.
4. Lander E, Kruglyak L (1995): Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 11:241-247.
5. Moldin SO, Van Eerdewegh P (1995): Multivariate genetic analysis of oligogenic disease. Genet Epidemiol 12:801-806.
6. Risch NJ, Merikangas K (1996): The future of genetic studies of complex human diseases. Science 273:1516-1517.
7. Risch NJ, Zhang H (1996): Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. Am J Hum Genet 58:836-843.
8. Suarez BK, Hampe CL, Van Eerdewegh P (1994): Problems of replicating linkage claims in psychiatry. In Gershon ES, Cloninger CR, Barrett JE (eds): "Genetic Approaches to Mental Disorders." Washington, DC: American Psychiatric Press, pp 23-46.