The interface between ageing and health in man

Age and Ageing

Volumn 26, Issue SUPPL. 4, 1997, Pages 9-14

  Kirkwood, Thomas B L ^a   Ritter, Mary A ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Age related disease; Ageing; Immunosenescence; Involution of thymus

Indexed keywords

AGING; CONFERENCE PAPER; HEALTH; HUMAN; IMMUNE SYSTEM; PRIORITY JOURNAL; SENESCENCE;

EID: 0031459797     PISSN: 00020729     EISSN: None     Source Type: Journal    
DOI: 10.1093/ageing/26.suppl_4.9     Document Type: Article

References (43)

1. Brody JA, Schneider EL. Diseases and disorders of agingan hypothesis. J Chron Dis 1986; 39: 871-6.
2. Evans JG. Aging and disease. In: Evered D, Whelan J (eds). Research and the Ageing Population. New York: John Wiley & Sons, 1988; 38-57.
3. Horan MA, Pendleton N. The relationship between aging and disease. Rev Clin Gerontol 1995; 5: 125-41.
4. Huppert FA, Brayne C, O'Connor DW. Dementia and Normal Aging. Cambridge: Cambridge University Press, 1994.
5. Comfort A. The Biology of Senescence, 3rd Edition. Edinburgh: Churchill Livingstone, 1979.
6. Finch CE. Longevity, Senescence and the Genome. Chicago, IL: Chicago University Press, 1990.
7. Kirkwood TBL. The evolution of ageing. Rev Clin Gerontol 1995; 5: 3-9.
8. Medawar PB. An Unsolved Problem of Biology. London: HK Lewis, 1952.
9. Williams GC. Pleiotropy, natural selection and the evolution of senescence. Evolution 1957; 11: 398-411.
10. Kirkwood TBL, Franceschi C. Is aging as complex as it would appear? New perspectives in aging research. Ann NY Acad Sci 1992; 663: 412-7.
11. Kirkwood TBL. Human senescence. BioEssays 1996; 18: 1009-16.
12. Kirkwood TBL. Evolution of ageing. Nature 1977; 270: 301-4.
13. Kirkwood TBL. Evolution of repair: survival versus reproduction. In: Townsend CR, Calow P (eds). Physiological Ecology: An Evolutionary Approach to Resource Use. Oxford: Blackwell Scientific Publications, 1981; 165-89.
14. Kirkwood TBL, Holliday R. Evolution of ageing and longevity. Proc R Soc Lond B 1979; 205: 531-46.
15. Kirkwood TBL, Cremer T. Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress. Hum Genet 1982; 60: 101-21.
16. Blaylock B. The ageing immune system and common infections in elderly patients. J ET Nurs 1993; 20: 63-7.
17. Janeway CA, Travers P. Immunobiology, 2nd Edition. Edinburgh: Churchill Livingstone, 1996.
18. - T cells in healthy ageing people, including centenarians. Immunology 1996; 88: 501-7.
19. --T cells in human blood lymphocytes with ageing. Clin Exp Immunol 1994; 98: 163-8.
20. Miller RA. The ageing immune system: primer and prospectus. Science 1996; 273: 70-4.
21. Whisler RL, Newhouse YG, Bagenstose SE. Age-related reductions in the activation of mitogen-activated protein kinases p44mapk/ERK1 and p42mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex. Cell Immunol 1996; 168: 201-10.
22. Grosmann A, Rabinovitch PS, Kavanagh TJ, Jinnemen JC, Gilliland LK, Ledbetter JA et al. Activation of murine T cells via phospholipase-C gamma 1-associated protein tyrosine phosphorylation is reduced with ageing. J Gerontol A Biol Sci Med Sci 1995; 50: B205-12.
23. Whisler RL, Beiqing L, Chen M. Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT. Cell Immunol 1996; 169: 185-95.
24. Trebilcock GU, Ponnappan U. Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging. Gerontology 1996; 42: 137-46.
25. Fulop T Jr, Leblanc C, Lacombe G, Dupuis G. Cellular distribution of protein kinase C isozymes in CD3-mediated stimulation of human T lymphcoytes with aging. FEBS Lett 1995; 375: 69-74.
26. Haruna J, Inaba M, Inaba K, Taketani S, Sugiura K, Fukuba Y et al. Abnormalities of B cells and dendritic cells in SAMP1 mice. Eur J Immunol 1995; 25: 1319-25.
27. Szakal AK, Kapasi ZF, Masuda A, Tew JG. Follicular dendritic cells in the alternative antigen transport pathway: microenvironment, cellular events, age and retrovirus related alterations. Semin Immunol 1992; 4: 257-65.
28. George AJT, Ritter MA. Thymic involution with aging: obsolescence or good housekeeping? Immunol Today 1996; 17: 267-72.
29. + T cell differentiation in vivo. Clin Exp Immunol 1994; 96: 528-34.
30. Palaavani MA, Richardson A. The effect of age on the expression of interleukin-2. Mech Ageing Dev 1996; 89: 125-54.
31. Born J, Uthgenannt D, Dodt C, Nunninghoff D, Ringvolt E, Wagner et al. Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep. Mech Ageing Dev 1995; 84: 113-26.
32. Weksler ME, Schwab R. The immunogenetics of immune senescence. Exp Clin Immunogenet 1992; 9: 182-7.
33. Hiyama K, Hirai Y, Kyoizumi S, Akiyama M, Hiyama E, Piatyszek et al. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 1995; 155: 3711-5.
34. + cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 1996; 10: F17-22.
35. Boyd RL, Tucek CL, Godfrey DI, Izon DJ, Wilson TJ, Davidson NJ et al. The thymic microenvironment. Immunol Today 1993; 14: 445-9.
36. Ritter MA, Boyd RL. Development in the thymus: it takes two to tango. Immunol Today 1993; 14: 462-9.
37. Ritter MA, George AJT. Thymic involvution: why bother? - a reply. Immunol Today 1996; 17: 493.
38. Nunez C, Nishimoto N, Gartland GL, Billips LG, Burrows PD, Kubagawa H et al. B Cells are generated throughout life in humans. J Immunol 1996; 156: 866-72.
39. Ben-Yehuda A, Szabo P, Dyall R, Weksler ME. Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution. Proc Natl Acad Sci USA 1994; 91: 11988-92.
40. Sheil AGR. Development of malignancy following renal transplantation in Australia and New Zealand. Transpl Proc 1992; 24: 1275-9.
41. Scheup M, Willcox N, Ritter MA, Newsom-Davis J, Larché M, Brown AN. Myasthenia gravis thymus: clinical, histological and culture conditions. J Autoimmunity 1988; 1: 445-67.
42. Smith H, Chen I-M, Kubo R, Tung KSK. Neonatal thymectomy results in a repertoire enriched in T cells deleted in adult thymus. Science 1089; 245: 749-52.
43. Snell GI, De Hoyos A, Winton T, Maurer JR. Lung transplantation in patients over the age of 50. Transplantation 1993; 55: 562-6.