Successful treatment with cyclosporine in a case of hemophagocytic syndrome manifesting as severe liver dysfunction

American Journal of the Medical Sciences

Volumn 314, Issue 6, 1997, Pages 403-407

  Omagari, Katsuhisa ^a   Ashida, Ryuichi ^a   Oh I, Hideo ^a   Minamino, Yasushi ^a   Sasaki, Osamu ^a   Ozono, Yoshiyuki ^a   Maeda, Takahiro ^a   Sadamori, Naoki ^a   Tomonaga, Masao ^a   Kohno, Shigeru ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cyclosporine; Hemaphagocytic syndrome; Liver dysfunction

Indexed keywords

CYCLOSPORIN A; IMMUNOGLOBULIN G; METHYLPREDNISOLONE;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; CORTICOSTEROID THERAPY; DISEASE SEVERITY; DRUG EFFECT; DRUG MEGADOSE; FEMALE; HEMOPHAGOCYTIC SYNDROME; HUMAN; IMMUNOTHERAPY; INTRAVENOUS DRUG ADMINISTRATION; LIVER DYSFUNCTION; PLASMAPHERESIS; TREATMENT PLANNING;

EID: 0031454731     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000441-199712000-00009     Document Type: Article

References (22)

1. Henter J-I, Blinder G, Ost A. Diagnostic guidelines for hemophagocytic lymphohistiocytosis. The FHL study group of the histiocyte society. Semin Oncol. 1991; 18:29-33.
2. Chen R-L, Lin K-H, Lin D-T, Su I-J, Huang L-M, Lee P-I, et al. Immunomodulation treatment for childhood virus-associated haemophagocytic lymphohistiocytosis. Br J Haematol. 1995; 89:282-90.
3. Risdall RJ, McKenna RW, Nesbit ME, Krivit W, Balfour HH Jr, Simmons RL, et al. Virus-associated hemophagocytic syndrome. A benign histiocytic proliferation distinct from malignant histiocytosis. Cancer. 1979; 44:993-1002.
4. Oyama Y, Amano T, Hirakawa S, Hironaka K, Suzuki S, Ota Z. Haemophagocytic syndrome treated with cyclosporin A: A T cell disorder? Br J Haematol. 1989; 73:276-8.
5. Thomson AW, Webster LM. The influence of cyclosporin A on cell-mediated immunity. Clin Exp Immunol. 1988; 71:369-76.
6. Ho S, Clipstone N, Timmermann L, Northrop J, Graef I, Florentino D, et al. The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol. 1996; 80:S40-5.
7. Wong K-F, Hui P-K, Chan JKC, Chan Y-W, Ha S-Y. The acute lupus hemophagocytic syndrome. Ann Intern Med. 1991; 114:387-90.
8. Kumakura S, Ishikura H, Endo J, Kobayashi S. Autoimmune-associated hemophagocytosis. Am J Hematol. 1995; 50:148-9.
9. Komp DM, McNamara J, Buckley P. Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes. Blood. 1989; 73:2128-32.
10. Sonneveld P, Lom KV, Kappers-Klunne M, Prins ME, Abels J. Clinicopathological diagnosis and treatment of malignant histiocytosis. Br J Haematol. 1990; 75:511-6.
11. Ishii E, Ohga S, Aoki T, Yamada S, Sato M, Tasaka H, et al. Prognosis of children with virus associated hemophagocytic syndrome and malignant histiocytosis: Correlation with levels of serum interleukin-1 and tumor necrosis factor. Acta Haematol. 1991; 85:93-9.
12. Fujiwara F, Hibi S, Imashuku S. Hypercytokinemia in hemophagocytic syndrome. Am J Pediatr Hematol Oncol. 1993; 15:92-8.
13. Gill DS, Spencer A, Cobcroft RG. High-dose τ-globulin therapy in the reactive haemophagocytic syndrome. Br J Haematol. 1994; 88:204-6.
14. Hirst WJR, Layton DM, Singh S, Mieli-Vergani G, Chessells JM, Strobel S, Pritchard J. Haemophagocytic lymphohistiocytosis: Experience at two U.K. centres. Br J Haematol. 1994; 88:731-9.
15. Imashuku S, Hibi S. Cytokines in haemophagocytic syndrome. Br J Haematol. 1991; 77:438-40.
16. Watson HG, Goulden NJ, Manson LM, McDermid G, Gray JA, Parker AC. Virus-associated haemophagocytic syndrome: Further evidence for a T-cell mediated disorder. Br J Haematol. 1994;86:213-5.
17. Reiner AP, Spivak JL. Hematophagic histiocytosis: A report of 23 new patients and a review of the literature. Medicine. 1988; 67:369-88.
18. Huang L-M, Lee C-Y, Lin K-H, Chuu W-M, Lee P-I, Chen R- L, et al. Human herpesvirus-6 associated with fatal haemophagocytic syndrome. Lancet. 1990; 336:60-1.
19. Asano Y, Yoshikawa T, Suga S, Yazaki T, Kondo K, Yamanishi K. Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection. Lancet. 1990; 335:862-3.
20. King PD, Diaz-Arias AA, Birkby WF, Loy TS. Reactive hemophagocytic syndrome simulating acute hepatitis. A case due to hepatic peripheral T-cell lymphoma. J Clin Gastroenterol. 1994; 19:234-7.
21. Beaugrand M, Trinchet JC, Callard P, Ferrier JP. Malignant histiocytosis presenting as a fulminant hepatic disease. Gastroenterology. 1983;84:447-8.
22. Arai M, Mochida S, Ohno A, Ogata I, Fujiwara K. Sinusoidal endothelial cell damage by activated macrophages in rat liver necrosis. Gastroenterology. 1993; 104:1466-71.