Glutathione-dependent antioxidant systems in the mammalian inner ear: Effects of aging, ototoxic drugs and noise

Hearing Research

Volumn 114, Issue 1-2, 1997, Pages 75-82

  Lautermann, Jürgen ^a   Crann, Sherry A ^a   McLaren, John ^a   Schacht, Jochen ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Age; Free radical; Glutathione; Noise trauma; Ototoxic drug

Indexed keywords

ANTIOXIDANT; CISPLATIN; FREE RADICAL; GENTAMICIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; COCHLEA; COCHLEAR NERVE; CONTROLLED STUDY; ENZYME ACTIVITY; EVOKED RESPONSE; GUINEA PIG; INNER EAR; MALE; NEUROEPITHELIUM; NOISE; NOISE INJURY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

AGING; ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; AUDITORY THRESHOLD; CISPLATIN; COCHLEA; FREE RADICALS; GENTAMICINS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; GUINEA PIGS; HOMEOSTASIS; MALE; NOISE; OXIDATIVE STRESS; RATS; RATS, INBRED F344; VESTIBULOCOCHLEAR NERVE;

EID: 0031454457     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5955(97)00154-8     Document Type: Article

References (49)

1. Axelsson, A., Vertes, D., Miller, J., 1981. Immediate noise effects on cochlear vasculature in the guinea pig. Acta Oto-Laryngol. 91, 237-246.
2. Backoff, P.M., Caspary, D.M., 1994. Age-related changes in auditory brainstem responses in Fischer 344 rats: effects of rate and intensity. Hear. Res. 73, 163-172.
3. Blum, J., Fridovich, I., 1985. Inactivation of glutathione peroxidase by superoxide radical. Arch. Biochem. Biophys. 240 (2), 500-508.
4. Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
5. Carrillo, M.C., Nokubo, M., Kitani, K., Satoh, K., Sato, K., 1991. Age-related alterations of enzyme activities and subunits of hepatic glutathione S-transferases in male and female Fischer-344 rats. Biochim. Biophys. Acta 1077, 325-331.
6. Clerici, W.J., Hensley, K., DiMartino, D.L., Butterfield, D.A., 1996. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear. Res. 98, 116-124.
7. El Barbary, A., Altschuler, R., Schacht, J., 1993. Glutathione S-transferase in the organ of Corti of the rat: enzymatic activity, subunit composition and immunohistochemical localization. Hear. Res. 71, 80-90.
8. Flohe, L., Gunzler, W.A., 1976. Glutathione-dependent enzymatic oxidoreduction reactions. In: Arias, I.M., Jakoby, W.B. (Eds.), Glutathione: Metabolism and Function. Raven Press, New York, pp. 17-34.
9. Flohe, L., Gunzler, W.A., 1984. Assays of glutathione peroxidase. Methods Enzymol. 105, 114-121.
10. Garetz, S.L., Rhee, D.J., Schacht, J., 1994a. Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro. Hear. Res. 77, 75-80.
11. Garetz, S.L., Altschuler, R.A., Schacht, J., 1994b. Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo. Hear. Res. 77, 81-87.
12. Habig, W.H., Pabst, M.J., Jakoby, W.B., 1974. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249, 7130-7139.
13. Harris, C., 1993. Glutathione biosynthesis in the postimplantation rat conceptus in vitro. Toxicol. Appl. Pharmacol. 120, 247-256.
14. Hawkins, J.E., Jr., 1971. The role of vasoconstriction in noise-induced hearing loss. Ann. Otol. Rhinol. Laryngol. 80, 903-913.
15. Hirose, K., Hockenberry, D.M., Rubel, E.W., 1997. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear. Res. 104, 1-14.
16. Hoffman, D.W., Whitworth, C.A., Jones-King, K.L., Rybak, L.P., 1988. Potentiation of ototoxicity by glutathione depletion. Ann. Otol. Rhinol. Laryngol. 97, 36-41.
17. Keithley, E.M., Ryan, A.F., Feldman, M.L., 1992. Cochlear degeneration in aged rats of 4 strains. Hear. Res. 59, 171-178.
18. Ketterer, B., 1988. Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mutat. Res. 202, 343-361.
19. Kirstein, C.L., Coopersmith, R., Bridges, R.J., Leon, M., 1991. Glutathione levels in olfactory and non-olfactory neural structures of rats. Brain Res. 543, 341-346.
20. Laurell, G., Engstrom, B., 1989. The ototoxic effect of cisplatin on guinea pigs in relation to dosage. Hear. Res. 38, 27-33.
21. Lautermann, J., McLaren, J., Schacht, J., 1995a. Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hear. Res. 86, 15-24.
22. Lautermann, J., Song, B., McLaren, J., Schacht, J., 1995b. Diet is a risk factor in cisplatin ototoxicity. Hear. Res. 88, 47-53.
23. Lawrence, R.A., Burk, R.F., 1976. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 71, 952-958.
24. Layne, E., 1957. Spectrophotometric and turbidimetric methods for measuring proteins. Methods Enzymol. 3, 447-454.
25. Leaf, G., Neuberger, A., 1947. The effect of diet on the glutathione content of the liver. Biochemistry 41, 280-287.
26. Maines, M.D., 1986. Differential effect of cis-platinum (cis-diamminedichloroplatinum) on regulation of liver and kidney haem and haemoprotein metabolism. Possible involvement of gamma-glutamyl-cycle enzymes. Biochem. J. 237, 713-721.
27. Matsuo, M., 1993. Age-related alterations in antioxidant defense. In: Yu, B.P. (Ed.), Free Radicals in Aging. CRC Press, Boca Raton, FL, pp. 143-181.
28. Meister, A., 1983. Selective modification of glutathione metabolism. Science 220, 472-477.
29. Meister, A., 1991. Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol. Ther. 51, 155-194.
30. Meister, A., Anderson, M.E., 1983. Glutathione. Annu. Rev. Biochem. 52, 711-760.
31. Muller, D.P.R., 1994. Vitamin E and other antioxidants in neurological function and disease. In: Frei, B. (Ed.), Natural Antioxidants in Human Health and Disease. Academic Press, New York, pp. 535-565.
32. Neuschwander-Tetri, B.A., Roll, F.J., 1989. Glutathione measurement by high-performance liquid chromatography separation and fluorometric detection of the glutathione-orthophthalaldehyde adduct. Anal. Biochem. 179, 236-241.
33. Ogawa, K., McLaren, J., Schacht, J., 1994. Effect of aging on myoinositol and phosphoinositide metabolism in the cochlear and vestibular sensory epithelia of the rat. Hear. Res. 73, 155-162.
34. Priuska, E.M., Schacht, J., 1995. Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem. Pharmacol. 50, 1749-1752.
35. Quirk, W.S., Shivapuja, B.G., Schwimmer, C.L., Seidman, M.D., 1994. Lipid peroxidation inhibitor attenuates noise-induced temporary threshold shifts. Hear. Res. 74, 217-220.
36. Ravi, R., Somani, S.M., Rybak, L.P., 1995. Mechanism of cisplatin ototoxicity: antioxidant system. Pharmacol. Toxicol. 76, 386-394.
37. Reed, D.J., Fariss, M.W., 1984. Glutathione depletion and susceptibility. Pharmacol. Rev. 36, 25S-33S.
38. Rybak, L.P., Ravi, R., Somani, S.M., 1995. Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity: antioxidant system. Fundam. Appl. Toxicol. 26, 293-300.
39. Sadzuka, Y., Shoji, T., Takino, Y., 1992. Effect of cisplatin on the activities of enzymes which protect against lipid peroxidation. Biochem. Pharmacol. 43, 1872-1875.
40. Schweitzer, V.G., 1993. Ototoxicity of chemotherapeutic agents. Otolaryngol. Clin. North Am. 26, 759-789.
41. Sha, S-H., Schacht, J., 1996. Amplification of free radicals by gentamicin in a biological system. Abs. Assoc. Res. Otolaryngol. 19, 30.
42. Sluis-Cremer, N., Naidoo, N., Dirr, H., 1996. Class-pi glutathione S-transferase is unable to regain its native conformation after oxidative inactivation by hydrogen peroxide. Eur. J. Biochem. 242, 301-307.
43. Smith, I.K., Vierheller, T.L., Thorne, C.A., 1988. Assay of glutathione reductase in crude tissue homogenates using 5,5′-dithio-bis(2-nitrobenzoic acid). Anal. Biochem. 175, 408-413.
44. Song, B.-B., Schacht, J., 1996. Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear. Res. 94, 87-93.
45. Tabatabaie, T., Floyd, R.A., 1994. Susceptibility of glutathione peroxidase and glutathione reductase to oxidative damage and the protective effect of spin trapping agents. Arch. Biochem. Biophys. 314 (1), 112-119.
46. Tran Ba Huy, P., Bernard, P., Schacht, J., 1986. Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs. J. Clin. Invest. 77, 1492-1500.
47. Usami, S., Hjelle, O.P., Ottersen, O.P., 1996. Differential cellular distribution of glutathione - an endogenous antioxidant - in the guinea pig inner ear. Brain Res. 743, 337-340.
48. Yamane, H., Nakai, Y., Takayama, M., Konishi, K., Iguchi, H., Nakagawa, T., Shibata, S., Kato, A., Sunami, K., Kawakatsu, C., 1995. The emergence of free radicals after acoustic trauma and strial blood flow. Acta Otolaryngol. Suppl. 519, 87-92.
49. Zhang, J.G., Lindup, W.E., 1994. Cisplatin nephrotoxicity: decreases in mitochondrial protein sulphydryl concentration and calcium uptake by mitochondria from rat renal cortical slices. Biochem. Pharmacol. 47, 1127-1135.