A pilot study of a combination of three reverse transcriptase inhibitors in HIV-1 infection

Antiviral Therapy

Volumn 2, Issue 4, 1997, Pages 219-227

  Lafeuillade, A ^a  

^a Hopital Chalucet Toulon   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DIDANOSINE; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DNA SEQUENCE; DRUG EFFICACY; DRUG TOXICITY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPH NODE; MALE; ORAL DRUG ADMINISTRATION; PILOT STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TECHNIQUE; VIRUS REPLICATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; AGED; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; DRUG THERAPY, COMBINATION; FEMALE; HIV-1; HUMANS; LYMPH NODES; MALE; MIDDLE AGED; PILOT PROJECTS; REVERSE TRANSCRIPTASE INHIBITORS; RNA, VIRAL;

EID: 0031449788     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS & Shaw GM. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995; 373:117-122.
2. Perelson AS, Neumann AU, Markowitz M, Leonard JM & Ho DD. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 1996; 271:1582-1586.
3. Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP & Fauci AS. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 1993; 362:355-358.
4. Embretson J, Zupancic M, Ribas JL, Burke A, Racz P, Tenner-Racz K & Haase AT. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 1993; 362:359-362.
5. Delta Coordinating Committee. Delta: a randomized double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals. Lancet 1996; 348:283-291.