Synthesis and biological activity of novel 2-(α- alkoxyimino)benzylpyridine derivatives as K+ channel openers

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 12, 1997, Pages 1994-2004

  Maekawa, Tsuyoshi ^a   Yamamoto, Satoshi ^a   Igata, Yumiko ^a   Ikeda, Shota ^a   Watanabe, Toshifumi ^a   Shiraishi, Mitsuru ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

(Z) 2 ( alkoxyimino)benzylpyridine; Hypotensive effect; K+ channel opener; Vasodilating effect; Vasorelaxant activity

Indexed keywords

CROMAKALIM; DILTIAZEM; GLYCERYL TRINITRATE; LEMAKALIM; NICORANDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BIOASSAY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOG; DRUG SYNTHESIS; FEMALE; INTRAARTERIAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; VASOCONSTRICTION; VASODILATATION;

EID: 0031444187     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.1994     Document Type: Article

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