메뉴 건너뛰기




Volumn 4, Issue 6, 1997, Pages 319-326

Role of mitochondria in human aging

Author keywords

Aging; Mitochondria; Mitochondrial DNA; Mutation; Oxidative damage; Reactive oxygen species

Indexed keywords

AEROBIC METABOLISM; AGING; CELL AGING; CELL DEGENERATION; CONFERENCE PAPER; DNA DAMAGE; HUMAN; HUMAN CELL; MACROMOLECULE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN MODIFICATION; TARGET CELL;

EID: 0031442754     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/BF02258357     Document Type: Conference Paper
Times cited : (40)

References (79)
  • 2
    • 0028007092 scopus 로고
    • DNA oxidative damage and life expectancy in houseflies
    • Agarwal S, Sohal RS. DNA oxidative damage and life expectancy in houseflies. Proc Natl Acad Sci USA 91:12332-12335;1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12332-12335
    • Agarwal, S.1    Sohal, R.S.2
  • 3
    • 0029594475 scopus 로고
    • Differential oxidative damage to mitochondrial proteins during aging
    • Agarwal S, Sohal RS. Differential oxidative damage to mitochondrial proteins during aging. Mech Ageing Dev 85:55-63;1995.
    • (1995) Mech Ageing Dev , vol.85 , pp. 55-63
    • Agarwal, S.1    Sohal, R.S.2
  • 4
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922;1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 7
    • 0025309791 scopus 로고
    • Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging
    • Bandy B, Davison AJ. Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging. Free Radic Biol Med 8:5213-5239;1990.
    • (1990) Free Radic Biol Med , vol.8 , pp. 5213-5239
    • Bandy, B.1    Davison, A.J.2
  • 8
    • 0028837939 scopus 로고
    • A topoisomerase II cleavage site is associated with a novel mitochondrial DNA deletion
    • Blok RB, Thorburn DR, Thompson GN, Dahl HHM. A topoisomerase II cleavage site is associated with a novel mitochondrial DNA deletion. Hum Genet 95:75-81;1995.
    • (1995) Hum Genet , vol.95 , pp. 75-81
    • Blok, R.B.1    Thorburn, D.R.2    Thompson, G.N.3    Dahl, H.H.M.4
  • 9
    • 0027244097 scopus 로고
    • Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced
    • Calleja M, Pena P, Ugalde C, Ferreiro C, Marco R, Garesse R. Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced. J Biol Chem 268:18891-18897;1993.
    • (1993) J Biol Chem , vol.268 , pp. 18891-18897
    • Calleja, M.1    Pena, P.2    Ugalde, C.3    Ferreiro, C.4    Marco, R.5    Garesse, R.6
  • 10
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527-605;1979.
    • (1979) Physiol Rev , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 11
    • 0019978703 scopus 로고
    • Replication of animal mitochondrial DNA
    • Clayton DA. Replication of animal mitochondrial DNA. Cell 28:693-705;1982.
    • (1982) Cell , vol.28 , pp. 693-705
    • Clayton, D.A.1
  • 12
    • 0000825475 scopus 로고
    • The absence of a pyrimidine dumer repair mechanism in mammalian mitochondria
    • Clayton DA, Doda JN, Friedberg EC. The absence of a pyrimidine dumer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci USA 71:2777-2781;1974.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 2777-2781
    • Clayton, D.A.1    Doda, J.N.2    Friedberg, E.C.3
  • 13
    • 0025674177 scopus 로고
    • Detection of a specific mitochondrial DNA deletion in tissues of older humans
    • Cortopassi GA, Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res 18:6927-6933;1990.
    • (1990) Nucleic Acids Res , vol.18 , pp. 6927-6933
    • Cortopassi, G.A.1    Arnheim, N.2
  • 14
    • 0029878894 scopus 로고    scopus 로고
    • Defective repair of oxidative damage in the mitochondrial DNA of a xeroderma pigmentosum group A cell line
    • Driggers WJ, Grishko VI, LeDoux SP, Wilson GL. Defective repair of oxidative damage in the mitochondrial DNA of a xeroderma pigmentosum group A cell line. Cancer Res 56:1262-1266;1996.
    • (1996) Cancer Res , vol.56 , pp. 1262-1266
    • Driggers, W.J.1    Grishko, V.I.2    LeDoux, S.P.3    Wilson, G.L.4
  • 16
    • 0027983133 scopus 로고
    • Oxygen radical induced mutagenesis is DNA polymerase specific
    • Feig DI, Loeb LA. Oxygen radical induced mutagenesis is DNA polymerase specific. J Mol Biol 235:33-41;1994.
    • (1994) J Mol Biol , vol.235 , pp. 33-41
    • Feig, D.I.1    Loeb, L.A.2
  • 17
    • 0025373259 scopus 로고
    • Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine
    • Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN. Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 87:4533-4537;1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 4533-4537
    • Fraga, C.G.1    Shigenaga, M.K.2    Park, J.W.3    Degan, P.4    Ames, B.N.5
  • 18
    • 0027284743 scopus 로고
    • Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster
    • Griswold CM, Matthews AL, Bewley KE, Mahaffey JW. Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster. Genetics 134:781-788;1993.
    • (1993) Genetics , vol.134 , pp. 781-788
    • Griswold, C.M.1    Matthews, A.L.2    Bewley, K.E.3    Mahaffey, J.W.4
  • 19
    • 0015319592 scopus 로고
    • The biological clock: The mitochondria?
    • Harman D. The biological clock: The mitochondria? J Am Geriatr Soc 20:145-147;1972.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 20
  • 21
    • 0025948247 scopus 로고
    • Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm
    • Hayakawa M, Torit K, Sugiyama S, Tanaka M, Ozawa T. Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm. Biochem Biophys Res Commun 179:1023-1029;1991.
    • (1991) Biochem Biophys Res Commun , vol.179 , pp. 1023-1029
    • Hayakawa, M.1    Torit, K.2    Sugiyama, S.3    Tanaka, M.4    Ozawa, T.5
  • 22
    • 0027055332 scopus 로고
    • Age-associated oxygen damage and mutations in mitochondrial DNA in human heart
    • Hayakawa M, Hattori K, Sugiyama S, Ozawa T. Age-associated oxygen damage and mutations in mitochondrial DNA in human heart. Biochem Biophys Res Commun 189:979-985;1992.
    • (1992) Biochem Biophys Res Commun , vol.189 , pp. 979-985
    • Hayakawa, M.1    Hattori, K.2    Sugiyama, S.3    Ozawa, T.4
  • 24
    • 0022975215 scopus 로고
    • An electron microscopic examination of age-related changes in the rat kidney: The influence of diet
    • Hayashida M, Yu BP, Masoro EJ, Iwasaki K, Ikeda T. An electron microscopic examination of age-related changes in the rat kidney: The influence of diet. Exp Gerontol 21:535-553;1986.
    • (1986) Exp Gerontol , vol.21 , pp. 535-553
    • Hayashida, M.1    Yu, B.P.2    Masoro, E.J.3    Iwasaki, K.4    Ikeda, T.5
  • 25
    • 0023883150 scopus 로고
    • Deletions of mitochondrial DNA in patients with mitochondrial myopathies
    • Holt IJ, Harding AE, Morgan-Hughes JA. Deletions of mitochondrial DNA in patients with mitochondrial myopathies. Nature 331:717-719;1988.
    • (1988) Nature , vol.331 , pp. 717-719
    • Holt, I.J.1    Harding, A.E.2    Morgan-Hughes, J.A.3
  • 26
    • 0029765459 scopus 로고    scopus 로고
    • The unusual structures of the hot-regions flanking large-scale deletions in human mitochondrial DNA
    • Hou JH, Wei YH. The unusual structures of the hot-regions flanking large-scale deletions in human mitochondrial DNA. Biochem J 318:1065-1070;1996.
    • (1996) Biochem J , vol.318 , pp. 1065-1070
    • Hou, J.H.1    Wei, Y.H.2
  • 27
    • 0023947327 scopus 로고
    • Evidence for mitochondrial DNA damage by lipid peroxidation
    • Hruszkewycz AM. Evidence for mitochondrial DNA damage by lipid peroxidation. Biochem Biophys Res Commun 153:191-197;1988.
    • (1988) Biochem Biophys Res Commun , vol.153 , pp. 191-197
    • Hruszkewycz, A.M.1
  • 28
    • 0026784592 scopus 로고
    • Lipid peroxidation and mtDNA degeneration. A hypothesis
    • Hruszkewycz AM. Lipid peroxidation and mtDNA degeneration. A hypothesis. Mutat Res 275:243-248;1992.
    • (1992) Mutat Res , vol.275 , pp. 243-248
    • Hruszkewycz, A.M.1
  • 30
    • 0029784635 scopus 로고    scopus 로고
    • Leupeptin causes an accumulation of lipofuscin-like substances and other signs of aging in kidneys of young rats: Further evidence for the protease inhibitor model of aging
    • Ivy GO, Roopsingh R, Kanai S, Ohta M, Sato Y, Kitani K. Leupeptin causes an accumulation of lipofuscin-like substances and other signs of aging in kidneys of young rats: Further evidence for the protease inhibitor model of aging. Ann N Y Acad Sci 786:12-23;1996.
    • (1996) Ann N Y Acad Sci , vol.786 , pp. 12-23
    • Ivy, G.O.1    Roopsingh, R.2    Kanai, S.3    Ohta, M.4    Sato, Y.5    Kitani, K.6
  • 31
    • 0021675999 scopus 로고
    • Inhibitors of lysosomal enzymes: Accumulation of lipofuscin-like dense bodies in the brain
    • Ivy GO, Schottler F, Wenzel J, Baudry M, Lynch G. Inhibitors of lysosomal enzymes: Accumulation of lipofuscin-like dense bodies in the brain. Science 226:985-987;1984.
    • (1984) Science , vol.226 , pp. 985-987
    • Ivy, G.O.1    Schottler, F.2    Wenzel, J.3    Baudry, M.4    Lynch, G.5
  • 32
    • 0031036917 scopus 로고    scopus 로고
    • An essential role for free radicals and derived species in signal transduction
    • Lander HM. An essential role for free radicals and derived species in signal transduction. FASEB J 11:118-124;1997
    • (1997) FASEB J , vol.11 , pp. 118-124
    • Lander, H.M.1
  • 33
    • 0345245162 scopus 로고
    • Decreased protein and puromycinylpeptide degradation in livers of senescent mice
    • Lavie L, Reznick AZ, Gershon D. Decreased protein and puromycinylpeptide degradation in livers of senescent mice. Mutat Res 275:217-225;1992.
    • (1992) Mutat Res , vol.275 , pp. 217-225
    • Lavie, L.1    Reznick, A.Z.2    Gershon, D.3
  • 34
    • 0028349234 scopus 로고
    • Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing
    • Lee HC, Pang CY, Hsu HS, Wei YH. Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing. Biochim Biophys Acta 1226:37-43;1994.
    • (1994) Biochim Biophys Acta , vol.1226 , pp. 37-43
    • Lee, H.C.1    Pang, C.Y.2    Hsu, H.S.3    Wei, Y.H.4
  • 35
    • 0028061412 scopus 로고
    • Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle
    • Lee HC, Pang CY, Hsu HS, Wei YH. Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle. FEBS Lett 354:79-83;1994.
    • (1994) FEBS Lett , vol.354 , pp. 79-83
    • Lee, H.C.1    Pang, C.Y.2    Hsu, H.S.3    Wei, Y.H.4
  • 37
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to ageing and degenerative disease
    • Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative disease. Lancet i:642-645;1989.
    • (1989) Lancet , vol.1 , pp. 642-645
    • Linnane, A.W.1    Marzuki, S.2    Ozawa, T.3    Tanaka, M.4
  • 38
    • 0025864512 scopus 로고
    • An integrated theory of aging as the result of mitochondrial DNA mutation in differentiated cells
    • Miquel J. An integrated theory of aging as the result of mitochondrial DNA mutation in differentiated cells. Arch Gerontol Geriatr 12:99-117;1991.
    • (1991) Arch Gerontol Geriatr , vol.12 , pp. 99-117
    • Miquel, J.1
  • 40
    • 0024366601 scopus 로고
    • Cytochrome-c-oxidase deficient cardiomyocytes in the human heart- And age-related phenomenon. A histochemical ultracytochemical study
    • Müller-Höcker J. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart- and age-related phenomenon. A histochemical ultracytochemical study. Am J Pathol 134:1167-1173;1989.
    • (1989) Am J Pathol , vol.134 , pp. 1167-1173
    • Müller-Höcker, J.1
  • 41
    • 0025673968 scopus 로고
    • Cytochrome c oxidase deficient fibers in the limb muscle and diaphragm of man without muscular disease: An age-related alteration
    • Müller-Höcker J. Cytochrome c oxidase deficient fibers in the limb muscle and diaphragm of man without muscular disease: An age-related alteration. J Neurol Sci 100:14-21;1990.
    • (1990) J Neurol Sci , vol.100 , pp. 14-21
    • Müller-Höcker, J.1
  • 42
    • 0027476395 scopus 로고
    • The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages
    • Münscher C, Rieger T, Müller-Höcker J, Kadenbach B. The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Lett 317:27-30;1993.
    • (1993) FEBS Lett , vol.317 , pp. 27-30
    • Münscher, C.1    Rieger, T.2    Müller-Höcker, J.3    Kadenbach, B.4
  • 43
    • 0017810263 scopus 로고
    • Do mitochondria produce oxygen radicals in vivo?
    • Nohl H, Hegner D. Do mitochondria produce oxygen radicals in vivo? Eur J Biochem 82:563-567;1978.
    • (1978) Eur J Biochem , vol.82 , pp. 563-567
    • Nohl, H.1    Hegner, D.2
  • 44
    • 0027293919 scopus 로고
    • Effects of Cu-Zn superoxide dismutase overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster
    • Orr WC, Sohal RS. Effects of Cu-Zn superoxide dismutase overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Arch Biochem Biophys 301:34-40;1993.
    • (1993) Arch Biochem Biophys , vol.301 , pp. 34-40
    • Orr, W.C.1    Sohal, R.S.2
  • 45
    • 0028220114 scopus 로고
    • Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
    • Orr WC, Sohal RS. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster Science 263:1128-1130;1994.
    • (1994) Science , vol.263 , pp. 1128-1130
    • Orr, W.C.1    Sohal, R.S.2
  • 46
    • 0029086910 scopus 로고
    • Extensive tissue oxygenation associated with mitochondrial DNA mutations
    • Ozawa T, Sahashi K, Nakase Y, Chance B. Extensive tissue oxygenation associated with mitochondrial DNA mutations. Biochem Biophys Res Commun 213:432-438;1995.
    • (1995) Biochem Biophys Res Commun , vol.213 , pp. 432-438
    • Ozawa, T.1    Sahashi, K.2    Nakase, Y.3    Chance, B.4
  • 47
    • 0027941299 scopus 로고
    • Human skin mitochondrial DNA deletions associated with light exposure
    • Pang CY, Lee HC, Yang JH, Wei YH. Human skin mitochondrial DNA deletions associated with light exposure. Arch Biochem Biophys 312:534-538;1994.
    • (1994) Arch Biochem Biophys , vol.312 , pp. 534-538
    • Pang, C.Y.1    Lee, H.C.2    Yang, J.H.3    Wei, Y.H.4
  • 48
    • 0030581498 scopus 로고    scopus 로고
    • Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications
    • Papa S. Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications. Biochim Biophys Acta 1276:87-105;1996.
    • (1996) Biochim Biophys Acta , vol.1276 , pp. 87-105
    • Papa, S.1
  • 49
    • 0024547664 scopus 로고
    • Null mutation of copper/zinc superoxide dismutase in Drosophila confer hypersensitivity to paraquat and reduced longevity
    • Phillips JP, Campbell SD, Michaud D, Charbonneau M, Hilliker AJ. Null mutation of copper/zinc superoxide dismutase in Drosophila confer hypersensitivity to paraquat and reduced longevity. Proc Natl Acad Sci USA 86:2761-2765;1989.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2761-2765
    • Phillips, J.P.1    Campbell, S.D.2    Michaud, D.3    Charbonneau, M.4    Hilliker, A.J.5
  • 50
    • 0029894544 scopus 로고    scopus 로고
    • Crosstalk between nuclear and mitochondrial genomes
    • Poyton RO. Crosstalk between nuclear and mitochondrial genomes. Annu Rev Biochem 65:563-607;1996.
    • (1996) Annu Rev Biochem , vol.65 , pp. 563-607
    • Poyton, R.O.1
  • 52
    • 0023811053 scopus 로고
    • Normal oxidative damage to mitochondrial and nuclear DNA is extensive
    • Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 85:6465-6467;1988.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6465-6467
    • Richter, C.1    Park, J.W.2    Ames, B.N.3
  • 53
    • 0028227936 scopus 로고
    • Mitochondnal encephalomyopathies: Clinical and molecular analysis
    • Schon EA, Hirano M, DiMauro S. Mitochondnal encephalomyopathies: Clinical and molecular analysis. J Bioenerg Biomembr 26:291-299;1994.
    • (1994) J Bioenerg Biomembr , vol.26 , pp. 291-299
    • Schon, E.A.1    Hirano, M.2    DiMauro, S.3
  • 54
    • 0029984062 scopus 로고    scopus 로고
    • Antioxidant and redox regulation of gene transcription
    • Sen CK, Packer L. Antioxidant and redox regulation of gene transcription. FASEB J 10:709-720;1996.
    • (1996) FASEB J , vol.10 , pp. 709-720
    • Sen, C.K.1    Packer, L.2
  • 55
    • 0024317560 scopus 로고
    • Spontaneous Keams-Sayre/chronic progressive external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: A slipreplication model and metabolic therapy
    • Shoffner JM, Lott MT, Voljavec AS, Soueidan SA, Costigan DA, Wallace DC. Spontaneous Keams-Sayre/chronic progressive external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: A slipreplication model and metabolic therapy. Proc Natl Acad Sci USA 86:7952-7956;1989.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7952-7956
    • Shoffner, J.M.1    Lott, M.T.2    Voljavec, A.S.3    Soueidan, S.A.4    Costigan, D.A.5    Wallace, D.C.6
  • 56
    • 0029039854 scopus 로고
    • Simultaneous overexpression of copper and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster
    • Sohal RS, Agarwal A, Agarwal S, Orr WC. Simultaneous overexpression of copper and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster J Biol Chem 270:15671-15674;1995.
    • (1995) J Biol Chem , vol.270 , pp. 15671-15674
    • Sohal, R.S.1    Agarwal, A.2    Agarwal, S.3    Orr, W.C.4
  • 57
    • 0028116159 scopus 로고
    • Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice
    • Sohal RS, Agarwal S, Candas M, Forster M, Lal H. Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev 76:215-224;1994.
    • (1994) Mech Ageing Dev , vol.76 , pp. 215-224
    • Sohal, R.S.1    Agarwal, S.2    Candas, M.3    Forster, M.4    Lal, H.5
  • 58
    • 0027328852 scopus 로고
    • Protein oxidative damage is associated with life expectancy of houseflies
    • Sohal RS, Agarwal S, Dubey A, Orr WC. Protein oxidative damage is associated with life expectancy of houseflies. Proc Natl Acad Sci USA 90:7255-7259;1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7255-7259
    • Sohal, R.S.1    Agarwal, S.2    Dubey, A.3    Orr, W.C.4
  • 60
    • 0028268734 scopus 로고
    • Mitochondrial oxidative damage, hydrogen peroxide release, and aging
    • Sohal RS, Dubey A. Mitochondrial oxidative damage, hydrogen peroxide release, and aging. Free Radic Biol Med 16:621-626;1994.
    • (1994) Free Radic Biol Med , vol.16 , pp. 621-626
    • Sohal, R.S.1    Dubey, A.2
  • 61
    • 0028342438 scopus 로고
    • Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
    • Sohal RS, Ku HH, Agarwal S, Forster MJ, Lal H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev 74:121-133;1994.
    • (1994) Mech Ageing Dev , vol.74 , pp. 121-133
    • Sohal, R.S.1    Ku, H.H.2    Agarwal, S.3    Forster, M.J.4    Lal, H.5
  • 62
    • 0026023219 scopus 로고
    • Hydrogen peroxide release by mitochondria increases during aging
    • Sohal RS, Sohal BH. Hydrogen peroxide release by mitochondria increases during aging. Mech Ageing Dev 57:187-202;1991.
    • (1991) Mech Ageing Dev , vol.57 , pp. 187-202
    • Sohal, R.S.1    Sohal, B.H.2
  • 63
    • 0029147191 scopus 로고
    • Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage and longevity in different species of flies
    • Sohal RS, Sohal BH, Orr WC. Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage and longevity in different species of flies. Free Radic Biol Med 19:499-504;1995.
    • (1995) Free Radic Biol Med , vol.19 , pp. 499-504
    • Sohal, R.S.1    Sohal, B.H.2    Orr, W.C.3
  • 64
    • 0026795635 scopus 로고
    • Protein oxidation and aging
    • Stadtman ER. Protein oxidation and aging. Science 257:1220-1224;1992.
    • (1992) Science , vol.257 , pp. 1220-1224
    • Stadtman, E.R.1
  • 65
    • 0024580556 scopus 로고
    • Decline in skeletal muscle mitochondrial respiratory chain function: Possible factor in ageing
    • Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: Possible factor in ageing. Lancet i:637-639;1989.
    • (1989) Lancet , vol.1 , pp. 637-639
    • Trounce, I.1    Byrne, E.2    Marzuki, S.3
  • 66
    • 0026624980 scopus 로고
    • Diseases of the mitochondrial DNA
    • Wallace DC. Diseases of the mitochondrial DNA. Annu Rev Biochem 61:1175-1212;1992.
    • (1992) Annu Rev Biochem , vol.61 , pp. 1175-1212
    • Wallace, D.C.1
  • 67
    • 0026746336 scopus 로고
    • Mitochondrial DNA alterations as ageing-associated molecular events
    • Wei YH. Mitochondrial DNA alterations as ageing-associated molecular events. Mutat Res 275:145-155;1992.
    • (1992) Mutat Res , vol.275 , pp. 145-155
    • Wei, Y.H.1
  • 68
    • 6844233567 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial DNA mutations in human aging
    • in press
    • Wei YH. Oxidative stress and mitochondrial DNA mutations in human aging. Proc Soc Exp Biol Med 1997, in press.
    • (1997) Proc Soc Exp Biol Med
    • Wei, Y.H.1
  • 69
    • 0029741620 scopus 로고    scopus 로고
    • Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process
    • Wei YH, Pang CY, You BJ, Lee HC. Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process. Ann N Y Acad Sci 786:82-101;1996.
    • (1996) Ann N Y Acad Sci , vol.786 , pp. 82-101
    • Wei, Y.H.1    Pang, C.Y.2    You, B.J.3    Lee, H.C.4
  • 70
    • 0019891031 scopus 로고
    • 1 complex of mitochondrial electron transport chain - Demonstration of QP-S radical formation
    • 1 complex of mitochondrial electron transport chain - demonstration of QP-S radical formation. Biochem Biophys Res Commun 99:1411-1419;1981.
    • (1981) Biochem Biophys Res Commun , vol.99 , pp. 1411-1419
    • Wei, Y.H.1    Scholes, C.P.2    King, T.E.3
  • 71
    • 0028826029 scopus 로고
    • Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress
    • Wheeler JC, Bieschke ET, Tower J. Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress. Proc Natl Acad Sci USA 92:10408-10412;1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10408-10412
    • Wheeler, J.C.1    Bieschke, E.T.2    Tower, J.3
  • 72
    • 0029121602 scopus 로고
    • Photoageing-associated mitochondrial DNA length mutations in human skin
    • Yang JH, Lee HC, Wei YH. Photoageing-associated mitochondrial DNA length mutations in human skin. Arch Dermatol Res 287:641-648;1995.
    • (1995) Arch Dermatol Res , vol.287 , pp. 641-648
    • Yang, J.H.1    Lee, H.C.2    Wei, Y.H.3
  • 74
    • 0025741445 scopus 로고
    • Ageing-associated 5 kb deletion in human liver mitochondrial DNA
    • Yen TC, Su JH, King KL, Wei YH. Ageing-associated 5 kb deletion in human liver mitochondrial DNA. Biochem Biophys Res Commun 178:124-131;1991.
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 124-131
    • Yen, T.C.1    Su, J.H.2    King, K.L.3    Wei, Y.H.4
  • 75
    • 0028933889 scopus 로고
    • Oxygen stress induces an apoptotic cell death associated with fragmentation of mitochondrial genome
    • Yoneda M, Katsumata K, Hayakawa M, Tanaka M, Ozawa T. Oxygen stress induces an apoptotic cell death associated with fragmentation of mitochondrial genome. Biochem Biophys Res Commun 209:723-729;1995.
    • (1995) Biochem Biophys Res Commun , vol.209 , pp. 723-729
    • Yoneda, M.1    Katsumata, K.2    Hayakawa, M.3    Tanaka, M.4    Ozawa, T.5
  • 76
    • 0026715879 scopus 로고
    • Nucleus-driven mutations of human mitochondrial DNA
    • Zeviani M. Nucleus-driven mutations of human mitochondrial DNA. J Inherit Metab Dis 15:456-471;1992.
    • (1992) J Inherit Metab Dis , vol.15 , pp. 456-471
    • Zeviani, M.1
  • 77
    • 0026532722 scopus 로고
    • Multiple mitochondrial DNA deletions in an elderly human individual
    • Zhang C, Baumer A, Maxwell RJ, Linnane AW, Nagley P. Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett 297:34-38;1992.
    • (1992) FEBS Lett , vol.297 , pp. 34-38
    • Zhang, C.1    Baumer, A.2    Maxwell, R.J.3    Linnane, A.W.4    Nagley, P.5
  • 78
    • 0027198359 scopus 로고
    • Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans
    • Zhang C, Linnane AW, Nagley P. Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans. Biochem Biophys Res Commun 195:1104-1110;1993.
    • (1993) Biochem Biophys Res Commun , vol.195 , pp. 1104-1110
    • Zhang, C.1    Linnane, A.W.2    Nagley, P.3
  • 79
    • 0031557682 scopus 로고    scopus 로고
    • Gross mosaic pattern of mitochondrial DNA deletions in skeletal muscle tissues of an individual adult human subject
    • Zhang C, Liu VWS, Nagley P. Gross mosaic pattern of mitochondrial DNA deletions in skeletal muscle tissues of an individual adult human subject. Biochem Biophys Res Commun 233:56-60;1997.
    • (1997) Biochem Biophys Res Commun , vol.233 , pp. 56-60
    • Zhang, C.1    Liu, V.W.S.2    Nagley, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.