Cellular and axonal migrations are misguided along both body axes in the maternal-effect mau-2 mutants of Caenorhabditis elegans

Development

Volumn 124, Issue 24, 1997, Pages 5115-5126

  Takagi, Shin ^a,c   Bénard, Claire ^a   Pak, Julia ^a,d   Livingstone, David ^b,e   Hekimi, Siegfried ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c NAGOYA UNIVERSITY   (Japan)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Axonal guidance; C. elegans; Cell migration; Maternal effect; mau 2

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CELL MIGRATION; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO AXIS; GENE; MUTANT; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AXONS; BODY PATTERNING; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALCIUM-BINDING PROTEINS; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM; FEMALE; GENES, HELMINTH; GENES, LETHAL; GONADS; HELMINTH PROTEINS; HERMAPHRODITISM; LARVA; MESODERM; MOVEMENT; MUTATION; NEURONS; PHENOTYPE; RECOMBINANT FUSION PROTEINS;

EID: 0031438438     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Ackerman, S.L., Kozak L.R., Przyborski S.A., Rund L.A., Boyer B.B. and Knowles B.B. (1997). The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein, Nature 386, 838-842.
2. Avery, L. (1993). The genetics of feeding in Caenorhabditis elegans. Genetics 133, 897-917.
3. Brenner, S. (1974). The genetics of Caenorhabditis elegans, Genetics 77, 71-94.
4. Chalfie, M. and Sulston, J. E. (1981). Developmental genetics of mechanosensory neurons in Caenorhabditis elegans. Dev. Biol. 102, 391-410.
5. Chen, E.B., Branda, C.S. and Stern, M.J. (1997). Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites. Dev. Biol. 182, 88-100.
6. Colamarino, S.A., and Tessier-Lavigne, M. (1995). The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81, 621-629.
7. Fazeli, A. et al. (1997). Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene. Nature 386, 796-804.
8. Fire, A. (1992). Histochemical techniques for locating Escherichia coli beta-galactosidase activity in transgenic organisms, Genet. Anal. Tech. Appl. 9, 5-6.
9. Hamelin, M., Scott, I. M., Way, J. C. and Culotti, J. G. (1992). The mec-7 beta-tubulin gene of Caenorhabditis elegans is expressed primarily in the touch receptor neurons. EMBO J 11, 2885-2893.
10. Hedgecock, E. M., Culotti, J. G., Thomson, J. N. and Perkins, L. A. (1985). Axonal guidance mutants of Caenorhabditis elegans identified by filling sensory neurons with fluorescein dyes. Dev Biol. 111, 158-170.
11. Hedgecock, E. M., Culotti, J. G., Hall, D. H. and Stern, B. D. (1987) Genetics of cell and axon migrations in Caenorhabditis elegans. Development 100, 365-382.
12. Hedgecock, E. M., Culotti, J. G. and Hall, D. H. (1990) The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 2, 61-85.
13. Hekimi, S. (1990). A neuron-specific antigen in C. elegans allows visualization of the entire nervous system. Neuron 4, 855-865.
14. Hekimi, S. and Kershaw, D. (1993). Axonal guidance detects in a Caenorhabditis elegans mutant reveal cell-extrinsic determinants of neuronal morphology. J. Neurosci. 13, 4254-4271.
15. Hekimi, S., Boutis, P. and Lakowski, B. (1995). Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans. Genetics 141, 1351-1364.
16. Ishii, N., Wadsworth W.G., Stern B.D. Culotti J.G., Hedgecock E.M. (1992). UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9: 873-881.
17. Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E.D., Chan, S.S., Culotti, J.G. and Tessier-Lavigne, M. (1996). Deleted in colorectal cancer (DCC) encodes a netrin receptor. Cell 87, 175-185.
18. Kennedy, T. E., Serafini, T., de la Torre, J. R. and Tessier-Lavigne, M. (1994). Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78, 425-435.
19. Leonardo, F.D., Hinck L., Masu M., Keino-Masu K., Ackerman S.L. and Tessier-Lavigne, M. (1997). Vertebrate homologues of C elegans UNO-5 are candidate netrin receptors. Nature 386, 833-838.
20. Leung-Hagesteijn, C.Y., Spence A.M., Stern B.D., Zhou Y.W., Su M.W., Hedgecock E.M. and Culotti J.G. (1992) UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type-1 domains, guides cell and pioneer axon migrations in C elegans. Cell 71, 289-299.
21. Lewis, J. A. and Hodgkin J. A. (1977). Specific neuroanatomical changes in chemosensory mutants of the nematode C. elegans. J. Comp. Neurol. 172, 489-510.
22. Livingstone, D. (1991). Studies on the unc-31 gene of Caenorhabditis elegans. PhD thesis. University of Cambridge, UK.
23. Manser, J. and Wood, W. B. (1990). Mutations affecting embryonic cell migrations in Caenorhabditis elegans. Dev. Genet. 11, 49-64.
24. McIntire, S.L., Garriga, G., White, J., Jacobson, D. and Horvitz, H. R. (1992). Genes necessary for directed axonal elongation or fasciculation in C. elegans. Neuron 8, 307-322.
25. Nelson, F.K. and Riddle, D. L. (1984). Functional study of the Caenorhabditis elegans secretory-excretory system using laser microsurgery. J. Exp. Zool. 231, 45-56.
26. Park, E.-C. and Horvitz, H. R. (1986). Mutations with dominant effects on the behavior and morphology of the nematode C. elegans. Genetics 113, 821-852.
27. Seeger, M., Tear, G., Ferres-Marco, D. and Goodman, C. S. (1993). Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10, 409-426.
28. Serafini, T., Kennedy, T. E., Galko, M. J., Mirzayan, C., Jessell, T. M. and Tessier-Lavigne, M. (1994). The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 404-424.
29. Starich, T. A., Herman, R. K., Kari, C. K., Schackwitz, W., Schuyler, M. W., Collet, P., Thomas, J. H. and Riddle, D. L. (1995). Mutations affecting the chemosensors neurons of Caenorhabditis elegans. Genetics 139, 171-188.
30. Sulston, J. E. and Horvitz, H. R. (1977). Post-embryonic cell lineages of the nematode Caenorhabditis elgans. Dev. Biol. 100, 110-156.
31. Sulston, J.E., Schierenberg, E., White, J. G. and Thomson, J. N. (1983). The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100, 64-119.
32. Thomas, J.H. (1990). Genetic analysis of defecation in Caenorhabditis elegans. Genetirs 124, 855-872.
33. Trent, C., Tsung, N. and Horvitz, H. R. (1983). Egg-laying detective mutants of the nematode Caenorhabditis elegans. Genetics 104, 619-647.
34. Wadsworth, W.G., Bhatt, H. and Hedgecock, E. M. (1996) Neuroglia and pioneer neurons express unc-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron 16, 15-46.
35. Wadsworth, W.G.,and Hedgecock, E. M. (1996). Hierarchical guidance cues in the developing nervous system of C elegans. BioEssays 18, 355-362.
36. White, J.G., Southgate, E., Thomson, J.N. and Brenner, S. (1986). The structure of the nervous system of the nematode Caenorhabditis elegans. Phil. Trans. R. Soc. Lond. B 314, 1-340.
37. Wightman, B., Clark, S.G., Taskar, A.M., Forrester, W.C., Maricq, A.V., Bargman, C.I. and Garriga, G. (1996). The C elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration. Development 122, 671-682.