Optimized high-performance liquid chromatographic method for determination of lamotrigine in serum with concomitant determination of phenytoin, carbamazepine, and carbamazepine epoxide

Therapeutic Drug Monitoring

Volumn 19, Issue 3, 1997, Pages 292-300

  Lensmeyer, Gary L ^a   Gidal, Barry E ^a   Wiebe, Donald A ^a  

^a University of Wisconsin Health   (United States)

Author keywords

Carbamazepine; High performance liquid chromatography; Lamotrigine; Phenytoin; Solid phase extractions

Indexed keywords

CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; LAMOTRIGINE; PHENYTOIN;

ACCURACY; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PLASMA; PRIORITY JOURNAL;

ANTICONVULSANTS; CARBAMAZEPINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; PHENYTOIN; TRIAZINES;

EID: 0031437729     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199706000-00009     Document Type: Article

References (30)

1. Goa K, Ross S, Crisp P. Lamotrigine: a review of its pharmacological properties and clinical efficacy in epilepsy. Drugs 1993;46(1):152-76.
2. Fraser A. New drugs for the treatment of epilepsy. Clin Biochem 1996;29:97-110.
3. Pisani F. Pharmacokinetics of lamotrigine from text lamotrigine: a new advance in the treatment of epilepsy. Reynolds EH, ed. New York: Royal Society of Medicine Services, 1993:15-20.
4. Rambeck B, Wolf P. Lamotrigine clinical pharmacokinetics. Clin Pharmacokinet 1993;25:433-4.
5. George S, Wood A, Braithwaite R. Routine therapeutic monitoring of lamotrigine in epileptic patients using a simple and rapid high performance liquid chromatographic technique. Ann Clin Biochem 1995;32:584-8.
6. Bialer M. Comparative pharmacokinetics of the newer antiepileptic drugs. Clin Pharmacokinet 1993;24:441-52.
7. Cohen A, Land G, Breimer D, Yuen W, Winton C, Peck A. Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans. Cin Pharmacol Ther 1987;42:535-41.
8. Sinz M, Remmel R. Isolation and characterization of a novel quaternary ammonium-linked glucuronide of lamotrigine. Drug Metab Dispos 1991;19:149-53.
9. Doig M, Clare R. Use of thermospray liquid chromatography-mass spectrometry to aid in the identification of urinary metabolites of a novel antiepileptic drug lamotrigine. J Chromatogr 1991;554:181-9.
10. Garnett W, Pellock J. Critical drug appraisal: lamotrigine-effective oral add-on therapy. Pharmacy Ther 1995;3:156-70.
11. Biddlecombe R, Dean K, Smith C, Jeal S. Validation of a radioimmunoassay for the determination of human plasma concentrations of lamotrigine. J Pharm Biomed Anal 1990; 8:691-4.
12. Ramachandran S, Underhill S, Jones S. Measurement of lamotrigine under conditions measuring phenobarbital, phenytoin, and carbamazepine using reversed-phase high-performance liquid chromatography at dual wavelengths. Ther Drug Monit 1994;16:75-82.
13. Sinz M, Remmel R. Analysis of lamotrigine and lamotrigine 2-N-glucuronide in guinea pig blood and urine by reversed- phase ion-pairing liquid chromatography. J Chromatogr 1991;571:217-30.
14. Fazio A, Artesi C, Russo M, Trio R, Oteri G, Pisani F. A liquid chromatographic assay using a high-speed column for the determination of lamotrigine, a new antiepileptic drug, in human plasma. Ther Drug Monit 1992;14:509-12.
15. Frazer A, MacNeil W, Isner A, Camfield P. Lamotrigine analysis in serum by high performance liquid chromatography. Ther Drug Monit 1995;17:174-8.
16. Papadoyannis I, Zotou A, Samanidou V. Solid-phase extraction study and RP-HPLC analysis pf lamotrigine in human biological fluids and in antiepileptic tablet formulations. J Liquid Chromatogr 1995;18:2593-609.
17. Yamashita S, Furuno K, Kawasaki H, et al. Simple and rapid analysis of lamotrigine, a novel antiepileptic, in human serum by high-performance liquid chromatography using solid-phase extraction technique. J Chromatogr 1995;670:354-7.
18. Cociglio M, Alric R, Bouvier O. Performance analysis of a reversed-phase liquid chromatographic assay of lamotrigine in plasma using solvent-demixing extraction. J Chromatogr 1991;572:269-76.
19. Juergens U. Alkylamine/phosphoric acid as a universal buffer system for basic and acidic mobile phases in HPLC. J Liquid Chromatogr 1988;11:1925-40.
20. Romanyshyn L, Wichman J, Kucharczyk N, Shumaker R, Ward D, Sofia R. Simultaneous determination of felbamate, primidone, phenobarbital, carbamazepine, two carbamazepine metabolites, phenytoin, and one phenytoin metabolite in human plasma by high-performance liquid chromatography. Ther Drug Monit 1994;16:90-9.
21. McIntosh S, Watson I, Kelly A, Stewart M. Automated HPLC of anticonvulsants: a cost assessment. Clin Chem 1989;35:1353.
22. Liu H, Delgado M, Forman L, Eggers C, Montoya J. Simultaneous determination of carbamazepine, phenytoin, phenobarbital, primidone, and their principle metabolites by high-performance liquid chromatography with photodiode-array detection. J Chromatogr 1993;616:105-15.
23. Kouno Y, Ishikura C, Homma M, Oka K. Simple and accurate high-performance liquid chromatographic method for the measurement of three antiepileptics in therapeutic drug monitoring. J Chromatogr 1993;622:47-52.
24. Eto S, Noda H, Noda A. Simultaneous determination of anti-epileptic drugs and their metabolites, including chiral compounds, via B-cyclodextrin inclusion complexes by a column-switching chromatographic technique. J Chromatogr 1994; 658:385-90.
25. Wells D, Lensmeyer G, Wiebe D. Particle-loaded membranes as an alternative to traditional packed-column sorbents for drug extraction: in-depth comparative study. J Chromatogr Sci 1995;33:386-92.
26. Lensmeyer G, Wiebe D, Darcey B. Application of a novel form of solid phase sorbent (Empore membrane) to the isolation of tricyclic antidepressant drugs from blood. J Chromatogr Sci 1991;29:444-9.
27. Lensmeyer G, Wiebe D, Doran T. Application of the Empore solid phase extraction membrane to the isolation of drugs from blood. I. Amiodarone and desethylamiodarone. Ther Drug Monit 1991;13:244-50.
28. Dorsey J, Cooper W. Retention mechanisms of bonded-phase liquid chromatography. Anal Chem 1994;66(17);857A-67A.
29. Koch D. How to evaluate and implement new technologies in an era of managed care and cost containment. Clin Chem 1996;42:797-802.
30. Gault M. Drug metabolites and immunoassays. Clin Chem 1994;40(10):1863-4.