Enhanced nephrotoxicity of acetaminophen in fructose-induced hypertriglyceridemic rats: Contribution of oxidation and deacetylation of acetaminophen to an enhancement of nephrotoxicity

Experimental and Toxicologic Pathology

Volumn 49, Issue 5, 1997, Pages 313-319

  Ishida, Katsuhiko ^a   Ikegami, Hisashi ^a   Doi, Kunio ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Acetaminophen; Bis(p nitrophenyl)phosphate; Fructose; Hepatotoxicity; Hypertriglyceridemia; Nephrotoxicity; Piperonyl butoxide

Indexed keywords

FRUCTOSE; PARACETAMOL; PIPERONYL BUTOXIDE; TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEACETYLATION; DRUG METABOLISM; HYPERTRIGLYCERIDEMIA; LIVER TOXICITY; MALE; METABOLISM; NEPHROTOXICITY; NONHUMAN; OXIDATION; RAT;

EID: 0031437610     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(97)80090-5     Document Type: Article

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