Effects of fructose-induced hypertriglyceridemia on hepatorenal toxicity of acetaminophen in rats: Role of pharmacokinetics and metabolism of acetaminophen

Experimental and Toxicologic Pathology

Volumn 49, Issue 3-4, 1997, Pages 207-215

  Ishida, Katsuhiko ^a   Sakazume, Masashi ^a   Watanabe, Masami ^a   Hirai, Nami ^a   Ikegami, Hisashi ^a   Sakai, Toshiharu ^a   Doi, Kunio ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Acetaminophen; Fructose induced; Fructose induced hypertriglyceridemia; Hepatorenal toxicity; Hypertriglyceridemia; Pharmacokinetics; Renal toxicity; Toxicity

Indexed keywords

CYTOCHROME P450; FRUCTOSE; GLUTATHIONE; PARACETAMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG LIVER LEVEL; DRUG METABOLISM; HYPERTRIGLYCERIDEMIA; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER TOXICITY; MALE; NEPHROTOXICITY; NONHUMAN; RAT;

ANIMALIA;

EID: 0030866352     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(97)80010-3     Document Type: Article

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