The 95-kilodalton membrane glycoprotein overexpressed in novel multidrug-resistant breast cancer cells is NCA, the nonspecific cross- reacting antigen of carcinoembryonic antigen

Cancer Research

Volumn 57, Issue 24, 1997, Pages 5460-5464

  Ross, Douglas D ^a   Gao, Yongming ^a   Yang, Weidong ^a   Leszyk, John ^b   Shively, John ^c   Doyle, L Austin ^a  

^a UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^b Worcester Foundation   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; DAUNORUBICIN; DOXORUBICIN; MEMBRANE PROTEIN; VERAPAMIL;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BREAST CANCER; EXPRESSION VECTOR; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIGENS, NEOPLASM; BLOTTING, WESTERN; BREAST NEOPLASMS; CARCINOEMBRYONIC ANTIGEN; CELL ADHESION MOLECULES; CROSS REACTIONS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EPITOPES; HELA CELLS; HUMANS; ISOELECTRIC FOCUSING; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PHENOTYPE; SODIUM DODECYL SULFATE; TUMOR CELLS, CULTURED;

EID: 0031436056     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Chen, Y-N., Mickley, L. A., Schwartz, A. M., Acton, E. M., Hwang, J., and Fojo, A. T. Characterization of Adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein. J. Biol. Chem., 265: 10073-10080, 1990.
2. Doyle, L. A., Ross, D. D., Sridhara, R., Fojo, A. T., Kaufmann, S. H., Lee, E. J., and Schiffer, C. A. Expression of a 95 kDa membrane protein is associated with low daunorubicin accumulation in leukaemic blast cells. Br. J. Cancer, 71: 52-58, 1995.
3. Lee, J. S., Scala, S., Matsumoto, Y., Dickstein, B., Robey, R., Zhan, Z., Altenberg, G., and Bates, S. E. Reduced drug accumulation and multidrug resistance without P-glycoprotein or MRP overexpression. J Cell. Biochem., 65: 513-526, 1997.
4. Ross, D. D., Doyle, L. A., Yang, Y., Tong, Y., and Cornblatt, B. Susceptibility of idarubicin, daunorubicin, and their C-13 alcohol metabolites to transport-mediated multidrug resistance. Biochem. Pharmacol., 50: 1673-1683, 1995.
5. Doyle, L. A., Kaufmann, S. H., Fojo, A. T., Bailey, C. L., and Gazdar, A. F. A novel 95 kilodalton membrane polypeptide associated with lung cancer drug resistance. Lung Cancer, 9: 317-326, 1993.
6. Doyle, L. A., Gao, Y., Yang, W., and Ross, D. D. Characterization of a 95 kilodalton membrane glycoprotein associated with multi-drug resistance. Int. J. Cancer, 62: 593-598, 1995.
7. Gazdar, A. F., Steinberg, S. M., Russell, E. K., Linnoila, R. I., Oie, H. K., Ghosh, B. C., Cotelingen, J. D., Johnson, B. E., Minna, J. D., and Ihde, D. C. Correlation of in vitro drug-sensitivity testing results with response to chemotherapy and survival in extensive-stage small cell lung cancer: a prospective clinical trial. J. Natl. Cancer Inst., 82: 117-124, 1990.
8. Gharahdaghi, F., Kirchner, M., Fernandez, J., and Mische, S. M. Peptide-mass profiles of polyvinylidene difluoride-bound proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in the presence of nonionic detergents. Anal. Biochem., 233: 94-99, 1996.
9. Gunning, P., Leavitt, J., Muscat, G., Ng, S-Y., and Kedes, L. A human β-actin expression vector system directs high level accumulation of antisense transcripts. Proc. Natl. Acad. Sci. USA, 84: 4831-4835, 1987.
10. Hefta, J. F., Schrewe, H., Thompson, J. A., Oikawa, S., Nakazato, H., and Shively, J. E. Expression and complementary DNA and genomic clones for carcinoembryonic antigen and nonspecific cross-reacting antigen in Chinese hamster ovary and mouse fibroblast cells and characterization of the membrane expressed products. Cancer Res., 50: 2397-2403, 1990.
11. Doyle, L. A., Yang, W., Rishi, A. K., Gao, Y., and Ross, D. D. H19 gene overexpression in atypical multidrug-resistant cells associated with expression of a 95-kilodalton membrane glycoprotein. Cancer Res., 56: 2904-2907, 1996.
12. Wagner, C., Joy Yang, Y. H., Crawford, F. G., and Shively, J. E. Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: a systematic approach for the determination of epitope specificities of monoclonal antibodies. J. Immunol., 130: 2308-2315, 1983.
13. Kawaharata, H., Hinoda, Y., Itoh, F., Endo, T., Oikawa, S., Nakazato, H., and Imai, K. Decreased sensitivity of carcinoembryonal antigen cDNA-transfected cells to adriamycin. Int. J. Cancer, 72: 377-382, 1997.
14. Tu, Y. Y., Primus, F. J., Shochat, D., and Goldenberg, D. M. Purification and characterization of carcinoembryonic antigen from GW-39, a xenografted human colonie tumor system. Tumor Biol., 9: 212-220, 1988.
15. Gianni, L., Corden, B., and Myers, C. The biochemical basis of anthracycline toxicity and antitumor action. Rev. Biochem. Toxicol., 5: 1-82, 1983.
16. Peterson, C., Baurain, R., and Trouet, A. The mechanism of cellular uptake, storage, and release of daunorubicin: studies on fibroblasts in culture. Biochem. Pharmacol., 29: 1687-1692, 1980.