Correlation between the expression of apoptosis-related bcl-2 and p53 oncoproteins and the carcinogenesis and progression of breast carcinomas

Clinical Cancer Research

Volumn 3, Issue 12 I, 1997, Pages 2329-2335

  Zhang, Guo Jun ^a   Kimijima, Izo ^a   Abe, Rikiya ^a   Kanno, Masahiko ^a   Katagata, Naoto ^a   Hara, Kiyoshi ^a   Watanabe, Takanori ^a   Tsuchiya, Atsuo ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

APOPTOSIS; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER INVASION; CORRELATION FUNCTION; DIAGNOSTIC VALUE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BREAST NEOPLASMS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CELL NUCLEUS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031427180     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Russo, J., and Russo, I. H. Biological and molecular bases of mammary carcinogenesis. Lab. Invest., 57: 112-137, 1987.
2. Shousha, S. Histopathology of breast carcinoma and related conditions. In: B. Hoogstraten, I. Burn, and H. J. G. Bloom (eds.), Breast Cancer, pp. 13-44. Berlin: Springer-Verlag, 1989.
3. Champeme, M. H., Bieche, I., Beuzelin, M., and Liderean, R. Loss of heterozygosity on 7q31 occurs early during breast tumorigenesis. Genes Chromosomes Cancer, 12: 304-306, 1995.
4. Schmitt, F. C., Figueiredo, P., and Lacerda, M. Expression of c-erbB-2 protein and DNA ploidy in breast carcinogenesis. Arch. Pathol. Lab. Med., 119: 815-820, 1995.
5. Allan, D. J., Howell, A., Roberts, S. A., Williams, G. T., Watson, R. J., Coyde, J. D., Clarke, R. B., Laidlaw, I. J., and Potten, C. S. Reduction in apoptosis relative to mitosis in histologically normal epithelium accompanies fibrocystic change and carcinoma of the premenopausal human breast. J. Pathol., 163: 337-342, 1991.
6. Wyllie, A. H. Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Metastasis Rev., 11: 95-103, 1992.
7. Lipponen, P., Aaltomaa, S., Kosma, V. M., and Syrjänen, K. Apoptosis in breast cancer as related to histopathological characteristics and prognosis. Eur. J. Cancer, 30A: 2068-2073, 1994.
8. Buja, L. M., Eigenbroot, M. L., and Eigenbroot, E. H. Apoptosis and necrosis: basic types and mechanisms of cell death. Arch. Pathol. Lab. Med., 117: 1208-1214, 1993.
9. Lu, Q. L., Elia, G., Lucas, S., and Thomas, J. A. Bcl-2 protooncogene expression in Epstein-Barr virus associated nasopharyngeal carcinoma. Int. J. Cancer, 53: 29-35, 1993.
10. Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., and Korsmeyer, S. J. bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA, 88: 6961-6965, 1991.
11. Watson, A. J. M., Merritt, A. J., Jones, L. S., Askew, J. N., Anderson, E., Becciolini, A., Balzi, M., Potten, C. S., and Hickman, J. A. Evidence for reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas. Br. J. Cancer, 73: 889-895, 1996.
12. Leek, R. D., Kaklamanis, L., Pezzella, F., Gatter, K. C., and Harris, A. L. bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumors and in situ cancer. Br. J. Cancer, 69: 135-139, 1994.
13. Silvestrini, R., Veneroni, S., Daidone, M. G., Benini, E., Boracchi, P., Mezzetti, M., Fronzo, G. D., Rilke, F., and Veronesi, U. The bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymphnode-negative breast cancer patients. J. Natl. Cancer Inst., 86: 499-504, 1995.
14. Zhang, G., Tsuda, H., Adachi, I., Fukutomi, T., Yamamoto, H., and Hirohashi, S. Value of cancer-related oncoprotein expression as prognostic factors in breast cancers with one to three axillary lymph nodes positive. Jpn. J. Cancer Chemother., 23 (Suppl. I): 66-74, 1996.
15. Gee, J. M. W., Robertson, J. F. R., Ellis, I. O., Willsher, P., McClelland, R. A., Hoyle, H. B., Kyme, S. R., Finlay, P., Blamey, R. W., and Nicholson, R. I. Immunocytochemical localization of bcl-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy. Int. J. Cancer, 59: 619-628, 1994.
16. Gasparini, G., Barbareschi, M., Doglioni, C., Palma, P. D., Mauri, F. A., Boracchi, P., Bevilacqua, P., Caffo, O., Morelli, L., Verderio, P., Pezzella, F., and Harris, A. L. Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer. Clin. Cancer Res., 1: 189-198, 1995.
17. Cattoretti, G., Rilke, F., Andreola, S., D'Amoto, L., and Delia, D. p53 expression in breast cancer. Int. J. Cancer, 41: 178-183, 1988.
18. Thor, A. D., Moore, D. H., II, Edgerton, S. M., Kawasaki, E. S., Reihsaus, E., Lynch, H. T., Marcus, J. N., Schwartz, L., Chen, L. C., Mayall, B. H., and Smith, H. S. Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancer. J. Natl. Cancer Inst., 84: 845-855, 1992.
19. Allred, D. C., Clark, G. M., Elledge, R., Fuqua, S. A. W., Brown, R. W., Chamness, G. C., Osborne, C. K., and McGuire, W. L. Association of P53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J. Natl. Cancer Inst., 85: 200-206, 1993.
20. Andersen, T. I., Holm, R., Nesland, J. M., Heimdal, K. R., Ottestad, L., and Bφrresen, A. L. Prognostic significance of TP53 alterations in breast carcinoma. Br. J. Cancer, 68: 540-548, 1993.
21. Friedrichs, K., Gluba, S., Eidtmann, H., and Jonat, W. Overexpression of p53 and prognosis in breast cancer. Cancer (Phila.), 72: 3641-3647, 1993.
22. Miyashita, T., and Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80: 293-299, 1995.
23. Poller, D. N., Roberts, E. C., Bell, J. A., Elston, C. W., Blamey, R. W., and Ellis, I. D. p53 protein in mammary ductal carcinoma in situ: relationship to immunohistochemical expression of estrogen receptor and c-erbB-2 protein. Hum. Pathol., 24: 463-468, 1993.
24. Tsuda, H., Iwaya, K., Fukutomi, T., and Hirohashi, S. p53 mutations and c-erbB-2 amplification in intraductal and invasive breast carcinomas of high histologic grade. Jpn. J. Cancer Res., 84: 394-401, 1993.
25. Charpin, C., DeVictor, B., Andrac, L., Amabile, J., Bergeret, D., LaVaut, M-N., Allasia, C., and Piana, L. p53 quantitative immunocytochemical analysis in breast carcinomas. Hum. Pathol., 26: 159-166, 1995.
26. El-Badawy, N., Cohen, C., Derose, P. B., Check, I. J., and Sgoutas, D. Immunohistochemical progesterone receptor assay: measurement by image analysis. Am. J. Clin. Pathol., 96: 704-710, 1991.
27. Bacus, S., Flower, J. L., Press, M. F., Bacus, J. W., and McCarty, K. S., Jr. The evaluation of estrogen receptor in primary breast carcinoma by computer-assisted image analysis. Am. J. Clin. Pathol., 90: 233-239, 1988.
28. Silvestrini, R., Benini, E., Daidone, M. G., Veneroni, S., Boracchi, P., Cappelletti, V., Fronzo, G. D., and Veronesi, U. P53 as an independent prognostic marker in lymph node-negative breast cancer patients. J. Natl. Cancer Inst., 85: 965-970, 1993.
29. Sinicrope, F. A., Ruan, S. B., Cleary, K. R., Stephens, C., Lee, J. J., and Levin, B. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res., 55: 237-241, 1995.
30. Kaklamanis, L., Savage, A., Mortensen, N., Tsiotos, P., Doussis-Anagnostopoulou, I., Biddolph, S., Whitehouse, R., Harris, A. L., and Gatter, K. C. Early expression of bcl-2 protem in the adenoma-carcinoma sequence of colorectal neoplasia. J. Pathol., 179: 10-14, 1996.
31. Haldar, S., Negrini, M., Monna, M., Sabbioni, S., and Croce, C. M. Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res., 54: 2095-2097, 1994.
32. Miyashita, T., Krajewski, S., Krajewska, M., Wang, H. G., Lin, H. K., Hoffman, B., Lieberman, D., and Reed, J. C. Tumor suppressor p53 is a regulator of bcl-2 and bax in gene expression in vitro and in vivo. Oncogene, 9: 1799-1805, 1994.
33. Barbareschi, M., Caffo, O., Veronese, S., Leek L. D., Fina, P., Fox, S., Bonzanini, M., Girlando, S., Morelli, L., Eccher, C., Pezzella, F., Doglioi, C., Plama P. D., and Harris, A. Bcl-2 and p53 expression in node-negative breast carcinoma. Hum. Pathol., 27: 1149-1155, 1996.
34. Kyprianou, N., English, H. F., Davidson, N. E., and Isaacs, J. T. Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation. Cancer Res., 51: 162-166, 1991.
35. Texeira, C., Reed, J. C., and Pratt, M. A. C. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res., 55: 3902-3907, 1995.
36. Iwaya, K., Tsuda, H., Hiraide, H., Tamaki, K., Tamakuma, S., Fukutomi, T., Mukai, K., and Hirohashi, S. Nuclear p53 immunoreaction associated with poor prognosis of breast cancer. Jpn. J. Cancer Res., 82: 835-840, 1991.
37. Isola, J., Visakorpi, T., Holli, K., and Kallioniemi, O. P. Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients. J. Natl. Cancer Inst., 84: 1109-1114, 1992.
38. Deng, G., Lu, Y., Zlotnikov, G., Thor, A. D., and Smith, H. S. Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science (Washington DC), 274: 2057-2059, 1996.
39. Ottesen, G. L., Christensen, I. J., Larsen, J. K., Hansen, B., and Anderson, J. A. Flow cytometric DNA analysis of breast cancers with predominance of carcinoma in situ: a comparison of the premalignant and malignant components. Clin. Cancer Res., 1: 881-888, 1995.
40. Siziopikou, K. P., Prioleau, J. E., Harris, J. R., and Schnitt, S. J. bcl-2 expression in the spectrum of preinvasive breast lesions. Cancer (Phila.), 77: 499-506, 1996.