Acetaminophen glucuronidation accurately reflects gluconeogenesis in fasted dogs

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 3 34-3, 1996, Pages

  Schwenk, W Frederick ^a   Kahl, Jane C ^a  

^a MAYO CLINIC   (United States)

Author keywords

carbohydrate metabolism; glycogen; hepatic glucose production; hepatic zonation; uridyl diphosphate glucose

Indexed keywords

PARACETAMOL; URIDINE DIPHOSPHATE GALACTOSE;

ANIMAL EXPERIMENT; ARTICLE; DIET RESTRICTION; DOG; DRUG GLUCURONIDATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; LIVER METABOLISM; NONHUMAN; PRIORITY JOURNAL;

EID: 0029797542     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.3.e529     Document Type: Article

References (19)

1. Cersosimo, E., R. L. Judd, and J. M. Miles. Insulin regulation of renal glucose metabolism in conscious dogs. J. Clin. Invest. 93: 2584-2589, 1994.
2. Dills, R. L., S. R. Howell, and C. D. Klaassen. Hepatic UDP-glucose and UDP-glucuronic acid synthesis rates in rats during a reduced energy state. Drug Metab. Dispos. 15: 281-288, 1987.
3. Dills, R. L., and C. D. Klaassen. Effect of reduced hepatic energy state on acetaminophen conjugation in rats. J. Pharmacol. Exp. Ther. 238: 463-472, 1986.
4. Ekberg, K., C. Visvanathan, K. Kumaran, W. C. Schumann, J. Wahren, and B. R. Landau. Gluconeogenesis and glucuronidation in liver in vivo and the heterogeneity of hepatocyte function. J. Biol. Chem. 270: 21715-21717, 1995.
5. Gebhardt, R. Metabolic zonation of the liver: regulation and implications for liver function. Pharmacol. Ther. 53: 275-354, 1992.
6. Hellerstein, M. K., D. J. Greenblatt, and H. N. Munro. Glycoconjugates as noninvasive probes of intrahepatic metabolism: pathways of glucose entry into compartmentalized hepatic UDP-glucose pools during glycogen accumulation. Proc. Natl. Acad. Sci. USA 83: 7044-7048, 1986.
7. Hellerstein, M. K., D. J. Greenblatt, and H. N. Munro. Glycoconjugates as noninvasive probes of intrahepatic metabolism I: kinetics of label incorporation with evidence of a common precursor UDP-glucose pool for secreted glycoconjugates. Metab. Clin. Exp. 36: 988-994, 1987.
8. Hellerstein, M. K., S. Kaempfer, J. S. Reid, K. Wu, and C. H. Shackelton. Rate of glucose entry into hepatic uridine diphosphoglucose by the direct pathway in fasted and fed states in normal humans. Metab. Clin. Exp. 44: 172-182, 1995.
9. Hellerstein, M. K., K. Wu, S. Kaempfer, W. P. Lee, S. Reid, and C. H. L. Shackleton. Non-invasive studies of intrahepatic metabolism in humans using mass spectroscopy (MS) I glucuronide (GluUA) probe (Abstract). Diabetes 38: 57A, 1989.
10. Hellerstein, M. K., and Y. Xie. The indirect pathway of hepatic glycogen synthesis and reduction of food intake by metabolic inhibitors. Life Sci. 53: 1833-1845, 1993.
11. Jungermann, K. Functional heterogeneity of periportal and perivenous hepatocytes. Enzyme 35: 161-180, 1986.
12. Magnusson, I., V. Chandramouli, W. C. Schumann, K. Kumaran, J. Wahren, and B. R. Landau. Quantitation of the pathways of hepatic glycogen formation on ingesting a glucose load. J. Clin. Invest. 80: 1748-1754, 1987.
13. Magnusson, I., V. Chandramouli, W. C. Schumann, K. Kumaran, J. Wahren, and B. R. Landau. Pathways of hepatic glycogen formation in humans following ingestion of a glucose load in the fed state. Metab. Clin. Exp. 38: 583-585, 1989.
14. 14C]glucose during hyperinsulinemia in humans. Diabetes 38: 97-107, 1989.
15. Miles, J. M., W. F. Schwenk, K. L. McClean, and M. W. Haymond. Determination of ketone body turnover in vivo with stable isotopes, utilizing gas chromatography/mass spectrometry. Anal. Biochem. 141: 110-115, 1994
16. Neese, R. A., J. M. Schwarz, D. Faix, S. Turner, A. Letscher, D. Vu, and M. K. Hellerstein. Gluconeogenesis and intrahepatic triose phosphate flux in response to fasting or substrate loads. Application of the mass isotopomer distribution analysis technique with testing of assumptions and potential problems. J. Biol. Chem. 270: 14452-14466, 1995.
17. Rother, K. I., and W. F. Schwenk. Glucose production in glycogen storage disease I is not associated with increased cycling through hepatic glycogen. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E774-E778, 1995.
18. Rother, K. I., and W. F. Schwenk. Hepatic glycogen accurately reflected by acetaminophen glucuronide in dogs refed after fasting. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E766-E773, 1995.
19. Shulman, G. I., G. Cline, W. C. Schumann, V. Chandramouli, K. Kumaran, and B. R. Landau. Quantitative comparison of pathways of hepatic glycogen repletion in fasted and fed humans. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E335-E341, 1990.