Ig V region hypermutation in B cell hybrids mimics in vivo mutation and allows for isolation of clonal variants

Molecular Immunology

Volumn 34, Issue 15, 1997, Pages 1095-1103

  Green, Nancy S ^a,d   Verdugo, Gonzalo ^a   Getman, Michael E ^b,c   Scharft, Matthew D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b WORCESTER POLYTECHNIC INSTITUTE   (United States)

^c Integrated Genetics   (United States)

^d Integrated Genetics ^*  (United States)

Author keywords

Hot spot; Hybridoma; IgH construct; Somatic mutation; V region

Indexed keywords

ARTICLE; B LYMPHOCYTE; GENETIC TRANSFECTION; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; PLASMACYTOMA; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN VARIANT; SOMATIC MUTATION;

EID: 0031426337     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00131-4     Document Type: Article

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